Results 11 to 20 of about 523,361 (299)
Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]
, 2015 In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano +9 more
core +7 more sources
The EMBO Journal, 2015 The self‐renewal and differentiation of tissue stem cells must be tightly controlled. Unrestrained self‐renewal leads to over‐proliferation of stem cells, which may cause tumor formation, while uncontrolled differentiation leads to depletion of the stem cell pool.
Xiaolei, Yin, Jeffrey M, Karp
openaire +2 more sources
American Economic Review, 1984 Economists have an instinctively negative reaction to any government program that creates a "notch," that is, a discontinuity in a budget constraint. For example, welfare programs like public housing are structured so that a finite lump of benefits is lost all at once when a household's income crosses a certain threshhold.
Alan S. Blinder, Harvey S. Rosen
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Journal of Public Health in Africa, 2011 Vital registration systems (VRS) are important in the collection of routine data on indicators of development. These are particularly useful if they are properly built to address weaknesses in the system leading to poor data quality.
Julius N. Fobil +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Leukemia-initiating cells play critical role in relapse, resistance to therapies and metastases but the mechanism remains largely elusive. We report that β-catenin is over-expressed in almost all T-ALL patients and flow sorted β-cateninhigh fractions are
Ling Zhang +9 more
doaj +1 more source
A Poglut1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss [PDF]
, 2016 Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limbgirdle muscular dystrophy, we identified a missense mutation in ...
Cabrera Serrano, Macarena +5 more
core +1 more source
Metals, 2023 Laser cutting is a suitable manufacturing method for generating complex geometries for sheet metal components. However, their cyclic load capacity is reduced compared to, for example, milled components. This is due to the influence of the laser-cut edge,
André T. Zeuner +7 more
doaj +1 more source
Notch signaling during human T cell development [PDF]
, 2012 Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy +97 more
core +2 more sources
Experimental and Numerical Investigation of the Mesoscale Size Effect in Notched Woven Composites
Applied Sciences, 2023 The uniaxial strength of 2 × 2 twill carbon fiber-epoxy composite with circular open holes is governed by the stress concentration induced by the notch, as well as by the variation of the material response with the stress localization.
Andrea Ferrarese +5 more
doaj +1 more source
Frontiers in Immunology, 2020 Extracellular vesicles (EVs) from adipose tissue-derived stem cells have been reported to attenuate lipopolysaccharide (LPS) induced inflammation and sepsis while the specific mechanism is unclear.
Xiaozhi Bai +8 more
doaj +1 more source