Results 21 to 30 of about 671,109 (238)
Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]
, 2015 In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano +9 more
core +7 more sources
The EMBO Journal, 2015 The self‐renewal and differentiation of tissue stem cells must be tightly controlled. Unrestrained self‐renewal leads to over‐proliferation of stem cells, which may cause tumor formation, while uncontrolled differentiation leads to depletion of the stem cell pool.
Xiaolei, Yin, Jeffrey M, Karp
openaire +2 more sources
On the Reduction of Stress Concentration Factor Around a Notch Using a Functionally Graded Layer [PDF]
Materials Research, 2015 The aim of this paper is to study the effect of functionally graded material (FGM) layer around a notch in a plate in three dimensions. Using exponential law of variation of Young's modulus and a coefficient of Poisson constant, the stress concentration ...
Sadek Gouasmi +4 more
doaj +2 more sources
American Economic Review, 1984 Economists have an instinctively negative reaction to any government program that creates a "notch," that is, a discontinuity in a budget constraint. For example, welfare programs like public housing are structured so that a finite lump of benefits is lost all at once when a household's income crosses a certain threshhold.
Alan S. Blinder, Harvey S. Rosen
openaire +2 more sources
Frontiers in Neuroscience, 2020 In contrast to mammals, the adult zebrafish brain shows neurogenic activity in a multitude of niches present in almost all brain subdivisions.
Nicolas Diotel +3 more
doaj +1 more source
Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways
Biology Open, 2021 The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required for angiogenesis resulting in sprouting and pruning of vessels to generate mature arborizing structures.
Grace X. Li +7 more
doaj +1 more source
Journal of Public Health in Africa, 2011 Vital registration systems (VRS) are important in the collection of routine data on indicators of development. These are particularly useful if they are properly built to address weaknesses in the system leading to poor data quality.
Julius N. Fobil +4 more
doaj +1 more source
Targeting the Notch Signaling Pathway in Chronic Inflammatory Diseases
Frontiers in Immunology, 2021 The Notch signaling pathway regulates developmental cell-fate decisions and has recently also been linked to inflammatory diseases. Although therapies targeting Notch signaling in inflammation in theory are attractive, their design and implementation ...
Panagiotis F. Christopoulos +8 more
doaj +1 more source
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling
Science, 2020 Cancer drivers converge on NOTCH Cancer genome–sequencing projects have emphasized the handful of genes mutated at high frequency in patients. Less attention has been directed to the hundreds of genes mutated in only a few patients—the so-called “long ...
S. Loganathan +12 more
semanticscholar +1 more source
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]
, 2016 The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita +5 more
core +1 more source