Results 1 to 10 of about 119,232 (259)

Genetic testing for aortic valve stenosis

The EuroBiotech Journal, 2018
Aortic valve stenosis (AVS) is a congenital aortic defect in which the aortic lumen narrows due to thickening or calcification of the aortic valve without obstructing left ventricular outflow.
Rakhmanov Yeltay, Maltese Paolo Enrico, Zulian Alessandra, Paolacci Stefano, Beccari Tommaso, Dundar Munis, Bertelli Matteo   +6 more
doaj   +1 more source

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. [PDF]

PLoS ONE, 2012
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in
Wenxue Ma, Alejandro Gutierrez, Daniel J Goff, Ifat Geron, Anil Sadarangani, Christina A M Jamieson, Angela C Court, Alice Y Shih, Qingfei Jiang, Christina C Wu, Kang Li, Kristen M Smith, Leslie A Crews, Neil W Gibson, Ida Deichaite, Sheldon R Morris, Ping Wei, Dennis A Carson, A Thomas Look, Catriona H M Jamieson   +19 more
doaj   +1 more source

The Predominant Prognostic Significance of NOTCH1 Mutation Defined by Emulsion PCR in Chronic Lymphocytic Leukemia

Cancer Management and Research, 2021
Katarzyna Skórka,1 Michał Chojnacki,1 Marta Masternak,1 Agnieszka Karczmarczyk,1 Edyta Subocz,2 Ewa Wawrzyniak,3 Krzysztof Giannopoulos1,4 1Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland; 2Department of ...
Skórka K, Chojnacki M, Masternak M, Karczmarczyk A, Subocz E, Wawrzyniak E, Giannopoulos K   +6 more
doaj  

Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]

, 2020
The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina, Cortés Ledesma, Felipe, Delgado Sainz, Irene, García Quintanilla, Lourdes, Jimeno González, Silvia, Martínez García, Pedro Manuel, Quintero, Cristina, Romero Granados, Rocío, Serrano Benítez, Almudena, Terrón Bautista, José, Álvarez Quilón, Alejandro   +10 more
core   +3 more sources

Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia

Journal of Integrative Neuroscience
Background: Ischemic stroke is the most common form of stroke and the second most common cause of death and incapacity worldwide. Its pathogenesis and treatment have been the focus of considerable research.
Wenjuan Li, Huachun Miao, Zeyin Nie, Feng Wu, Huaibin Li   +4 more
doaj   +1 more source

BRD4 regulates self‐renewal ability and tumorigenicity of glioma‐initiating cells by enrichment in the Notch1 promoter region

Clinical and Translational Medicine, 2020
Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones and nonhistone chromatin factors and have been classified as curative ...
Zhennan Tao, Xuetao Li, Hao Wang, Guangliang Chen, Zibin Feng, Yue Wu, Haoran Yin, Guozheng Zhao, Zhitong Deng, Chaohui Zhao, Yanyan Li, Ting Sun, Youxin Zhou   +12 more
doaj   +1 more source

An unexpected tumor suppressor role for VAV1a

Molecular & Cellular Oncology, 2018
RHO GDP/GTP exchange factors, including VAV1, are considered key protumorigenic factors. Against this paradigm, we have found that VAV1 plays tumor suppressor roles by buffering NOTCH1 signals in thymocytes.
Xosé R. Bustelo, L. Francisco Lorenzo-Martín, Myriam Cuadrado, Isabel Fernández-Pisonero, Javier Robles-Valero   +4 more
doaj   +1 more source

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer [PDF]

, 2017
Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor ...
Attwood, Kristopher, Chatta, Gurkamal, Granger, Victoria, Gueron, Geraldine, Guru, Khurshid, Hu, Qiang, Johnson, Candace, Krishnan, Nithya, McNally, Lacey, Morrison, Carl, Pili, Roberto, Rak, Monika, Ramakrishnan, Swathi, Smit, Evelyn, Wang, Dan, Wang, Jianmin, Woloszynska-Read, Anna   +16 more
core   +3 more sources

NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. [PDF]

, 2018
Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome.
Bellavia, Diana, Besharat, ZEIN MERSINI, Capalbo, Carlo, Checquolo, Saula, D'Amati, Giulia, Del Gaudio, Francesca, Diluvio, Giulia, Franciosa, Giulia, Giuli, MARIA VALERIA, Giuliani, Eugenia, Maroder, Marella, Palermo, Rocco, Pignataro, MARIA GEMMA, Talora, Claudio, Vacca, Alessandra   +14 more
core   +2 more sources

The oncogenic role of NOTCH1 as biomarker in oral squamous cell carcinoma and oral lichen planus

Dental Research Journal, 2023
Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer with heterogeneous molecular pathogenesis. Oral lichen planus (OLP) is demonstrated potentially can transfer to OSCC malignant lesions.
Ensieh Sagheb Sadeghi, Fatemeh Saeid Nematpour, Nooshin Mohtasham, Farnaz Mohajertehran   +3 more
doaj   +1 more source