Results 1 to 10 of about 123,777 (321)

Expression of Notch1 in Ameloblastoma and Correlation with CBCT Imaging Subtypes

Central Asian Journal of Medical Sciences, 2023
Objective: Ameloblastoma (AM) is a prevalent benign odontogenic tumor affecting the jaw bone. Its potential for recurrence and malignant transformation is closely associated with the regulation of signaling pathways.
Baoyinbatu Gabiyatu, Wenchao Li, Wurihan, Yuan Tian, Lkhagvasuren Baasandorj, Senhao Li, Sarnai Tsagaankhuu, Damdindorj Boldbaatar   +7 more
doaj   +3 more sources

Notch1 Mutation Represents a Potential Therapeutic Target to Enhance Immune Recognition in Oral Squamous Cell Carcinoma [PDF]

Cancer Reports
Background Notch1, a tumor suppressor gene, is one of the most frequently mutated genes in head and neck squamous cell carcinoma (HNSCC). Therefore, it is clinically important to investigate the effects of Notch1 mutations on antitumor immunity in oral ...
Takahiro Iwamoto, Kazuhiro Ogi, Takafumi Nakagaki, Takashi Sasaya, Sho Miyamoto, Koyo Nishiyama, Kenta Sasaki, Shintaro Sugita, Yasushi Sasaki, Akihiro Miyazaki   +9 more
doaj   +2 more sources

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]

, 2015
In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Di Ianni, Mauro, Falzetti, Franca, Marconi, Pierfrancesco, Rosati, Emanuela, Sabatini, Rita, Screpanti, Isabella, Sportoletti, Paolo   +9 more
core   +14 more sources

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]

, 2010
Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Barbara M. Grüner, Bence Sipos, Freddy Radtke, Hassan Nakhai, Jens T. Siveke, Joseph Alan Bauer, Lothar J. Strobl, Pawel K. Mazur, Roland M. Schmid, Ursula Zimber-Strobl   +9 more
core   +13 more sources

Multi-omics reveals that NOTCH1 promotes cervical cancer progression and reduces radiosensitivity. [PDF]

Front Immunol
Guo A, Su Z, Zhang E, Lin H, Zhong P, Xie Z, Zhan Q, Ye T, Sun Y.   +8 more
europepmc   +3 more sources

Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis

Open Medicine, 2023
Radiotherapy resistance is a challenge for colorectal cancer (CRC) treatment. Circular RNAs (circRNAs) play vital roles in the occurrence and development of CRC.
Wang Ximin, Zheng Dongxu, Wang Changting, Chen Wanhua   +3 more
doaj   +1 more source

Prognostic value of NOTCH1 and OCT4 in gastric carcinoma

Indian Journal of Pathology and Microbiology, 2022
Background: NOTCH1 pathway activation has been recently described to be a key player in gastric carcinogenesis, enhance the survival and proliferation of cancer stem cells (CSCs) and mediate chemoresistance in several malignancies.
Doaa Abdelaziz Ibrahim, Eman A Elsebai, Alaa Fayed, Aziza E Abdelrahman   +3 more
doaj   +1 more source

Growth differentiation factor 11 promotes macrophage polarization towards M2 to attenuate myocardial infarction via inhibiting Notch1 signaling pathway

Frigid Zone Medicine, 2023
Myocardial infarctions (MI) is a major threat to human health especially in people exposed to cold environment. The polarization of macrophages towards different functional phenotypes (M1 macrophages and M2 macrophages) is closely related to MI ...
Gong Manyu, Yang Xuewen, Wang Yaqi, Wang Yanying, Liu Dongping, Li Haodong, Qu Yunmeng, Zhang Xiyang, Zhang Yanwei, Sun Han, Jiao Lei, Zhang Ying   +11 more
doaj   +1 more source

KLF9 Promotes Osteogenic Differentiation of Dental Stem Cells by Negatively Regulating Notch1 Mediated Signaling Pathway

Frontiers in Bioscience-Landmark, 2023
Background: Human dental stem cells (DSCs) are excellent sources of cells for treating dental and craniofacial diseases. However, the mechanisms regulating DSC osteogenic differentiation are still unclear. In this study, we aimed to determine the role of
Xinyuan Zhao, Zizhao Mai, Ye Lu, Li Cui, Jinhua Yu   +4 more
doaj   +1 more source

Molecular genetic abnormalities in patients with T-cell acute lymphoblastic leukemia: a literature review

Онкогематология, 2022
T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematological disease. Modern polychemotherapy protocols allow achieving a 5-year overall survival of 60–90 % in different age groups, however, relapses and refractory forms of T-ALL ...
A. N. Vasileva, O. A. Aleshina, B. V. Biderman, A. B. Sudarikov   +3 more
doaj   +1 more source