Results 11 to 20 of about 123,777 (321)

Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]

Frontiers in Immunology, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto, Piovan, Erich, Tosello, Valeria, Zanovello, Paola   +3 more
core   +5 more sources

Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling [PDF]

Cancer Biology & Therapy, 2009
The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties. Suggesting a functional relationship, each gene can act to promote or suppress tumorigenesis in a context-dependent manner, and alteration of KLF4 or Notch pathway genes in mice gives rise to similar phenotypes. Activation of a conditional allele of
Zhaoli, Liu, Lihong, Teng, Sarah K, Bailey, Andra R, Frost, Kirby I, Bland, Albert F, LoBuglio, J Michael, Ruppert, Susan M, Lobo-Ruppert   +7 more
openaire   +2 more sources

Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling [PDF]

BMB Reports, 2015
Notch signaling plays a pivotal role in cell fate determination, cellular development, cellular self-renewal, tumor progression, and has been linked to developmental disorders and carcinogenesis. Notch1 is activated through interactions with the ligands of neighboring cells, and acts as a transcriptional activator in the nucleus.
Lee, Hye-Jin, Kim, Mi-Yeon, Park, Hee-Sae   +2 more
openaire   +2 more sources

Notch1 haploinsufficiency in mice accelerates adipogenesis [PDF]

Scientific Reports, 2021
Abstract Notch signaling has been recognized recently as a key regulator of metabolism. Here, we determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant (N1+/−) mice provided with 12-week normal or high-fat diet.
Kazutoshi Yamaguchi, Motoharu Hayashi, Yasuhiro Uchida, Xian Wu Cheng, Takayuki Nakayama, Tadashi Matsushita, Toyoaki Murohara, Kyosuke Takeshita   +7 more
openaire   +3 more sources

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Targetable NOTCH1 rearrangements in reninoma

Nature Communications, 2023
AbstractReninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli. They are the central component of the juxtaglomerular apparatus which controls systemic blood pressure through the secretion of renin.
Taryn D. Treger, John E. G. Lawrence, Nathaniel D. Anderson, Tim H. H. Coorens, Aleksandra Letunovska, Emilie Abby, Henry Lee-Six, Thomas R. W. Oliver, Reem Al-Saadi, Kjell Tullus, Guillaume Morcrette, J. Ciaran Hutchinson, Dyanne Rampling, Neil Sebire, Kathy Pritchard-Jones, Matthew D. Young, Thomas J. Mitchell, Philip H. Jones, Maxine Tran, Sam Behjati, Tanzina Chowdhury   +20 more
openaire   +5 more sources

Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating the microRNA-34a-5p/NOTCH1 signaling pathway

Open Life Sciences, 2020
Multiple myeloma (MM) is a serious health issue in hematological malignancies. Long non-coding RNA taurine-upregulated gene 1 (TUG1) has been reported to be highly expressed in the plasma of MM patients. However, the functions of TUG1 in MM tumorigenesis
Zhang Yongtian, Zhao Dandan, Li Shumei, Xiao Meng, Zhou Hongjing, Yang Shuige, Hao Yunliang, Dong Shasha   +7 more
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia

Frontiers in Oncology, 2022
NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL).
Jennifer Edelmann
doaj   +1 more source

ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes [PDF]

, 2007
ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets.
A. A. Ferrando, A. A. Margolin, A. Califano, Ashburner, Basso, Buck, Buck, Ferrando, G. Stolovitzky, Gibbons, Glynn, Hughes, Keles, Kim, Lee, Li, Matys, Miele, Odom, P. Sumazin, Palomero, Palomero, Pelengaris, Qi, Ren, Sandelin, T. Palomero, Weng   +27 more
core   +3 more sources