Results 11 to 20 of about 119,232 (259)
Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
Frontiers in Immunology, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto +3 more
core +5 more sources
Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL [PDF]
, 2015 In chronic lymphocytic leukemia (CLL), Notch1 and Notch2 signaling is constitutively activated and contributes to apoptosis resistance. We show that genetic inhibition of either Notch1 or Notch2, through small-interfering RNA, increases apoptosis of CLL ...
Baldoni, Stefano +9 more
core +10 more sources
Expression of Notch1 in Ameloblastoma and Correlation with CBCT Imaging Subtypes
Central Asian Journal of Medical Sciences, 2023 Objective: Ameloblastoma (AM) is a prevalent benign odontogenic tumor affecting the jaw bone. Its potential for recurrence and malignant transformation is closely associated with the regulation of signaling pathways.
Baoyinbatu Gabiyatu +7 more
doaj +1 more source
Epithelial transformation by KLF4 requires Notch1 but not canonical Notch1 signaling [PDF]
Cancer Biology & Therapy, 2009 The transcription factors Notch1 and KLF4 specify epithelial cell fates and confer stem cell properties. Suggesting a functional relationship, each gene can act to promote or suppress tumorigenesis in a context-dependent manner, and alteration of KLF4 or Notch pathway genes in mice gives rise to similar phenotypes. Activation of a conditional allele of
Zhaoli, Liu +7 more
openaire +2 more sources
Open Medicine, 2023 Radiotherapy resistance is a challenge for colorectal cancer (CRC) treatment. Circular RNAs (circRNAs) play vital roles in the occurrence and development of CRC.
Wang Ximin +3 more
doaj +1 more source
Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling [PDF]
BMB Reports, 2015 Notch signaling plays a pivotal role in cell fate determination, cellular development, cellular self-renewal, tumor progression, and has been linked to developmental disorders and carcinogenesis. Notch1 is activated through interactions with the ligands of neighboring cells, and acts as a transcriptional activator in the nucleus.
Lee, Hye-Jin +2 more
openaire +2 more sources
Prognostic value of NOTCH1 and OCT4 in gastric carcinoma
Indian Journal of Pathology and Microbiology, 2022 Background: NOTCH1 pathway activation has been recently described to be a key player in gastric carcinogenesis, enhance the survival and proliferation of cancer stem cells (CSCs) and mediate chemoresistance in several malignancies.
Doaa Abdelaziz Ibrahim +3 more
doaj +1 more source
Notch1 haploinsufficiency in mice accelerates adipogenesis [PDF]
Scientific Reports, 2021 Abstract Notch signaling has been recognized recently as a key regulator of metabolism. Here, we determined the role of Notch1 in adipogenesis in wild-type (WT) and Notch1 hetero-mutant (N1+/−) mice provided with 12-week normal or high-fat diet.
Kazutoshi Yamaguchi +7 more
openaire +3 more sources
Frigid Zone Medicine, 2023 Myocardial infarctions (MI) is a major threat to human health especially in people exposed to cold environment. The polarization of macrophages towards different functional phenotypes (M1 macrophages and M2 macrophages) is closely related to MI ...
Gong Manyu +11 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Human dental stem cells (DSCs) are excellent sources of cells for treating dental and craniofacial diseases. However, the mechanisms regulating DSC osteogenic differentiation are still unclear. In this study, we aimed to determine the role of
Xinyuan Zhao +4 more
doaj +1 more source