Results 21 to 30 of about 123,777 (321)
Notch1ablation radiosensitizes glioblastoma cells [PDF]
Oncotarget, 2017 Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients.
Han, Na +9 more
openaire +2 more sources
Inhibition of NOTCH1 signaling in tumor-initiating cells overcomes chemoresistance and promotes apoptosis [PDF]
Archives of Biological Sciences, 2021 The Notch signaling pathway is an evolutionarily conserved pathway essential for regulation of cell development and differentiation. Upregulation and activation of Notch signaling enhances the oncogenic potential of cancer cells through ...
Rui Yang +4 more
doaj +1 more source
Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]
, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen +6 more
core +2 more sources
Optogenetic control of NOTCH1 signaling
Cell Communication and Signaling, 2022 Abstract The Notch signaling pathway is a crucial regulator of cell differentiation as well as tissue organization, whose deregulation is linked to the pathogenesis of different diseases. NOTCH1 plays a key role in breast cancer progression by increasing proliferation, maintenance of cancer stem cells, and impairment of cell death ...
Joanna Kałafut +6 more
openaire +3 more sources
Isolation and Molecular Characterization of Spermatogonial Stem Cells in Nile Tilapia [PDF]
Journal of Bioscience and Applied Research, 2017 The identification and isolation of spermatogonial stem cells in Nile tilapia is crucial to the development of high-quality transplantation techniques as well as to understand the regulation of spermatogonia in vivo.
Heba Allah Elbaghdady +3 more
doaj +1 more source
CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS [PDF]
, 2017 No abstract ...
A de Lourdes Perim +14 more
core +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency [PDF]
, 2020 The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T).
Bernal Lozano, Cristina +10 more
core +3 more sources
Cancers, 2022 The Notch signaling pathway plays a fundamental role for the terminal differentiation of multiple cell types, including B and T lymphocytes. The Notch receptors are transmembrane proteins that, upon ligand engagement, undergo multiple processing steps that ultimately release their intracytoplasmic portion. The activated protein ultimately operates as a
Federico Pozzo +8 more
openaire +3 more sources
BMC Cancer, 2022 Background Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted agent. NOTCH1 is also expressed in
Shinsuke Suzuki +8 more
doaj +1 more source