Results 21 to 30 of about 119,232 (259)

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas? [PDF]

, 2016
The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro-oncogenic, typically depending on the cellular context.
Biswas, Sangita, Deng, Wenbing, Gong, Wenrong, Qin, Xin, Yu, Hongjun, Zhang, Min   +5 more
core   +1 more source

Targetable NOTCH1 rearrangements in reninoma

Nature Communications, 2023
AbstractReninomas are exceedingly rare renin-secreting kidney tumours that derive from juxtaglomerular cells, specialised smooth muscle cells that reside at the vascular inlet of glomeruli. They are the central component of the juxtaglomerular apparatus which controls systemic blood pressure through the secretion of renin.
Taryn D. Treger, John E. G. Lawrence, Nathaniel D. Anderson, Tim H. H. Coorens, Aleksandra Letunovska, Emilie Abby, Henry Lee-Six, Thomas R. W. Oliver, Reem Al-Saadi, Kjell Tullus, Guillaume Morcrette, J. Ciaran Hutchinson, Dyanne Rampling, Neil Sebire, Kathy Pritchard-Jones, Matthew D. Young, Thomas J. Mitchell, Philip H. Jones, Maxine Tran, Sam Behjati, Tanzina Chowdhury   +20 more
openaire   +5 more sources

Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating the microRNA-34a-5p/NOTCH1 signaling pathway

Open Life Sciences, 2020
Multiple myeloma (MM) is a serious health issue in hematological malignancies. Long non-coding RNA taurine-upregulated gene 1 (TUG1) has been reported to be highly expressed in the plasma of MM patients. However, the functions of TUG1 in MM tumorigenesis
Zhang Yongtian, Zhao Dandan, Li Shumei, Xiao Meng, Zhou Hongjing, Yang Shuige, Hao Yunliang, Dong Shasha   +7 more
doaj   +1 more source

Isolation and Molecular Characterization of Spermatogonial Stem Cells in Nile Tilapia [PDF]

Journal of Bioscience and Applied Research, 2017
The identification and isolation of spermatogonial stem cells in Nile tilapia is crucial to the development of high-quality transplantation techniques as well as to understand the regulation of spermatogonia in vivo.
Heba Allah Elbaghdady, Sayed Areida, Hany Marei, Hamada Salem   +3 more
doaj   +1 more source

NOTCH1 Signalling: A key pathway for the development of high-risk chronic lymphocytic leukaemia

Frontiers in Oncology, 2022
NOTCH1 is a cell surface receptor that releases its intracellular domain as transcription factor upon activation. With the advent of next-generation sequencing, the NOTCH1 gene was found recurrently mutated in chronic lymphocytic leukaemia (CLL).
Jennifer Edelmann
doaj   +1 more source

The molecular basis of T cell acute lymphoblastic leukemia [PDF]

, 2012
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando, Bash, Bash, Chen, Condorelli, Dube, Fisch, Hagemeijer, Hebert, Ho, Kelliher, Kikuchi, Larson, Lu, McGuire, McGuire, Nagel, Ntziachristos, Ntziachristos, Ono, Pieter Van Vlierberghe, Royer-Pokora, Rubnitz, van Grotel   +23 more
core   +1 more source

CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS [PDF]

, 2017
No abstract ...
A de Lourdes Perim, A Kumar, AM Gomez, AP Weng, BL Asselin, CH Pui, D Passaro, JL Cannon, K Letendre, M Thome, MP Felli, MT Williams, P Van Vlierberghe, S Buonamici, Y Ma   +14 more
core   +1 more source

Notch1ablation radiosensitizes glioblastoma cells [PDF]

Oncotarget, 2017
Broad specific Notch1 inhibitors suppress glioblastoma multiforme (GBM) growth but have significant gastrointestinal toxicities. Here, we examined Notch1 expression in GBM tissue specimens and its correlation with the overall survival (OS) of GBM patients.
Han, Na, Hu, Guangyuan, Shi, Lei, Long, Guoxian, Yang, Lin, Xi, Qingsong, Guo, Qiuyun, Wang, Jianhua, Dong, Zhen, Zhang, Mengxian   +9 more
openaire   +2 more sources

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Optogenetic control of NOTCH1 signaling

Cell Communication and Signaling, 2022
Abstract The Notch signaling pathway is a crucial regulator of cell differentiation as well as tissue organization, whose deregulation is linked to the pathogenesis of different diseases. NOTCH1 plays a key role in breast cancer progression by increasing proliferation, maintenance of cancer stem cells, and impairment of cell death ...
Joanna Kałafut, Jakub Czapiński, Alicja Przybyszewska-Podstawka, Arkadiusz Czerwonka, Adrian Odrzywolski, Cecilia Sahlgren, Adolfo Rivero-Müller   +6 more
openaire   +3 more sources