Results 31 to 40 of about 123,777 (321)

Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. [PDF]

, 2013
Postnatal/adult neural stem cells (NSCs) within the rodent subventricular zone (SVZ; also called subependymal zone) generate doublecortin (Dcx)(+) neuroblasts that migrate and integrate into olfactory bulb circuitry.
Abdi, Khadar, Benner, Eric, Eroglu, Cagla, Jo, Rebecca, Kuo, Chay, Liu, Chunlei, Luciano, Dominic, Paez-Gonzalez, Patricia, Sheng, Huaxin, Warner, David   +9 more
core   +1 more source

Genetic testing for aortic valve stenosis

The EuroBiotech Journal, 2018
Aortic valve stenosis (AVS) is a congenital aortic defect in which the aortic lumen narrows due to thickening or calcification of the aortic valve without obstructing left ventricular outflow.
Rakhmanov Yeltay, Maltese Paolo Enrico, Zulian Alessandra, Paolacci Stefano, Beccari Tommaso, Dundar Munis, Bertelli Matteo   +6 more
doaj   +1 more source

Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease [PDF]

, 2016
Background: Notch1 signaling is a cellular cascade with a fundamental role from brain development to adult brain function. Reduction in Notch1 affects synaptic plasticity, memory and olfaction.
Alberi, Lavinia, Brai, Emanuele, Raio, Noemi Alina   +2 more
core   +1 more source

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas [PDF]

, 2011
Copyright © 2011 Cantilena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Cantilena, S, Chayka, O, Pastorino, F, Pezzolo, A, Pistoia, V, Ponzoni, M, Sala, A   +6 more
core   +2 more sources

NOTCH1 Aberrations in Chronic Lymphocytic Leukemia [PDF]

Frontiers in Oncology, 2018
Chronic lymphocytic leukemia (CLL) is an incurable B-cell neoplasm characterized by highly variable clinical outcomes. In recent years, genomic and molecular studies revealed a remarkable heterogeneity in CLL, which mirrored the clinical diversity of this disease.
Emanuela Rosati, Stefano Baldoni, Filomena De Falco, Beatrice Del Papa, Erica Dorillo, Chiara Rompietti, Elisa Albi, Franca Falzetti, Mauro Di Ianni, Mauro Di Ianni, Paolo Sportoletti   +10 more
openaire   +3 more sources

The Predominant Prognostic Significance of NOTCH1 Mutation Defined by Emulsion PCR in Chronic Lymphocytic Leukemia

Cancer Management and Research, 2021
Katarzyna Skórka,1 Michał Chojnacki,1 Marta Masternak,1 Agnieszka Karczmarczyk,1 Edyta Subocz,2 Ewa Wawrzyniak,3 Krzysztof Giannopoulos1,4 1Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland; 2Department of ...
Skórka K, Chojnacki M, Masternak M, Karczmarczyk A, Subocz E, Wawrzyniak E, Giannopoulos K   +6 more
doaj  

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. [PDF]

PLoS ONE, 2012
Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in
Wenxue Ma, Alejandro Gutierrez, Daniel J Goff, Ifat Geron, Anil Sadarangani, Christina A M Jamieson, Angela C Court, Alice Y Shih, Qingfei Jiang, Christina C Wu, Kang Li, Kristen M Smith, Leslie A Crews, Neil W Gibson, Ida Deichaite, Sheldon R Morris, Ping Wei, Dennis A Carson, A Thomas Look, Catriona H M Jamieson   +19 more
doaj   +1 more source

BRD4 regulates self‐renewal ability and tumorigenicity of glioma‐initiating cells by enrichment in the Notch1 promoter region

Clinical and Translational Medicine, 2020
Bromodomain and extraterminal domain (BET) family proteins are considered to be epigenetic readers that regulate gene expression by recognizing acetyl lysine residues on histones and nonhistone chromatin factors and have been classified as curative ...
Zhennan Tao, Xuetao Li, Hao Wang, Guangliang Chen, Zibin Feng, Yue Wu, Haoran Yin, Guozheng Zhao, Zhitong Deng, Chaohui Zhao, Yanyan Li, Ting Sun, Youxin Zhou   +12 more
doaj   +1 more source

Astragalus Polysaccharide Promotes Neuronal Injury Repair via the Notch1/NFκB Signaling Axis in the Ventroposterior Thalamic Nucleus in Rats with Focal Cerebral Ischemia

Journal of Integrative Neuroscience
Background: Ischemic stroke is the most common form of stroke and the second most common cause of death and incapacity worldwide. Its pathogenesis and treatment have been the focus of considerable research.
Wenjuan Li, Huachun Miao, Zeyin Nie, Feng Wu, Huaibin Li   +4 more
doaj   +1 more source

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

, 2009
Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji, Fukumori, Akio, Haass, Christian, Hasegawa, Hiroshi, Hosono, Motoko, Itoh, Naohiro, Jiang, Jingwei, Kato, Akira, Katoh, Takaaki, Kikuchi, Jyunko, Kudo, Takashi, Minagawa, Kazuyuki, Mori, Kohji, Morihara, Takashi, Nakano, Yuko, Nakayama, Taisuke, Nishigaki, Atsuko, Nishimura, Masaki, Nishitomi, Kouhei, Okochi, Masayasu, Sakaguchi, Gaku, Tagami, Shinji, Takeda, Masatoshi, Takemoto, Hiroshi, Takinami, Yoshihiko, Tanaka, Toshihisa, Willem, Michael, Yanagida, Kanta   +27 more
core   +1 more source