Results 41 to 50 of about 123,777 (321)

An unexpected tumor suppressor role for VAV1a

Molecular & Cellular Oncology, 2018
RHO GDP/GTP exchange factors, including VAV1, are considered key protumorigenic factors. Against this paradigm, we have found that VAV1 plays tumor suppressor roles by buffering NOTCH1 signals in thymocytes.
Xosé R. Bustelo, L. Francisco Lorenzo-Martín, Myriam Cuadrado, Isabel Fernández-Pisonero, Javier Robles-Valero   +4 more
doaj   +1 more source

Targeting Microglia/Macrophages Notch1 Protects Neurons from Pyroptosis in Ischemic Stroke

Brain Sciences, 2023
Background and Aims: The immune-inflammatory cascade and pyroptosis play an important role in the pathogenesis of cerebral ischemia-reperfusion injury (CIRI).
Ran Chen, Hua Zhu, Zhihui Wang, Yonggang Zhang, Jin Wang, Yingao Huang, Lijuan Gu, Changyong Li, Xiaoxing Xiong, Zhihong Jian   +9 more
doaj   +1 more source

Hydroxytyrosol protects isoproterenol-induced myocardial infarction through activating notch signaling [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): In this investigation, the protective effects of hydroxytyrosol (HT) administered prior to myocardial infarction in rats were examined, with a particular focus on its potential roles within the Notch pathway.Materials and Methods: The ...
Elif Onat, Ahmet Türk, Nevin Kocaman, Serhat Hançer, Solmaz Susam, Ali Parlar, Selin Turhan, Mehmet Ozer   +7 more
doaj   +1 more source

Molecular Characterization of Notch1 Positive Progenitor Cells in the Developing Retina. [PDF]

PLoS ONE, 2015
The oscillatory expression of Notch signaling in neural progenitors suggests that both repressors and activators of neural fate specification are expressed in the same progenitors.
Galina Dvoriantchikova, Isabel Perea-Martinez, Steve Pappas, Ariel Faye Barry, Dagmara Danek, Xenia Dvoriantchikova, Daniel Pelaez, Dmitry Ivanov   +7 more
doaj   +1 more source

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable Cardiac Anomalies. [PDF]

, 2015
BACKGROUND: Adams-Oliver syndrome (AOS) is a rare disorder characterized by congenital limb defects and scalp cutis aplasia. In a proportion of cases, notable cardiac involvement is also apparent.
Brancati, F, Coerdt, W, Collinson, CS, Dallapiccola, B, Digilio, MC, Graul-Neumann, LM, Jacquemin, E, Joss, S, Karountzos, ASV, Machado, RD, Ruddy, D, Salviati, L, Snape, KM, Southgate, L, Sukalo, M, Taylor, EJ, Tolmie, JL, Trembath, RC, Wuyts, W, Zenker, M   +19 more
core   +3 more sources

T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology

Molecular & Cellular Oncology, 2018
Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype ...
Guillermo Rodríguez-Hernández, Sanil Bhatia, Carolina Vicente-Dueñas, Arndt Borkhardt, Julia Hauer, Isidro Sánchez-García   +5 more
doaj   +1 more source

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer

Frontiers in Immunology, 2019
Stromal cells and pro-inflammatory cytokines play key roles in promoting the aggressiveness of triple-negative breast cancers (TNBC; Basal/Basal-like).
Yulia Liubomirski, Shalom Lerrer, Tsipi Meshel, Dina Morein, Linor Rubinstein-Achiasaf, David Sprinzak, Stefan Wiemann, Cindy Körner, Marcelo Ehrlich, Adit Ben-Baruch   +9 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer [PDF]

, 2017
Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor ...
Attwood, Kristopher, Chatta, Gurkamal, Granger, Victoria, Gueron, Geraldine, Guru, Khurshid, Hu, Qiang, Johnson, Candace, Krishnan, Nithya, McNally, Lacey, Morrison, Carl, Pili, Roberto, Rak, Monika, Ramakrishnan, Swathi, Smit, Evelyn, Wang, Dan, Wang, Jianmin, Woloszynska-Read, Anna   +16 more
core   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source