Results 71 to 80 of about 119,232 (259)

Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase [PDF]

Molecular and Cellular Biology, 2015
Notch1 is an evolutionarily conserved transmembrane receptor involved in melanoma growth. Notch1 is first cleaved by furin in the Golgi apparatus to produce the biologically active heterodimer. Following ligand binding, Notch1 is cleaved at the cell membrane by proteases such as ADAM10 and -17 and membrane type 1 matrix metalloproteinase (MT1-MMP), the
Hong, Qiu, Xiaoying, Tang, Jun, Ma, Khvaramze, Shaverdashvili, Keman, Zhang, Barbara, Bedogni   +5 more
openaire   +2 more sources

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery

, 2010
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail.
Amberger, Bader, Bader, Bauer-Mehren, Becker, Behar, Berger, Berglund, Beyer, Bhattacharyya, Borisov, Boyle, Chaudhuri, Chen, Csaba Böde, Cusick, Davidov, Dennis, Drysdale, Dávid Fazekas, Fabbro, Frame, Freeman, Friedland, Gao, Harris, Hoffmann, Hopkins, Hornberg, Hunter, Illés J. Farkas, Joshi-Tope, Kandasamy, Katalin Lenti, Kholodenko, Klein, Komarova, Korcsmaros, Levine, Li, Liu, Lu, Luo, Morioka, Máté S. Szalay, O'Brien, Ogata, Papin, Petra Rovó, Pires-daSilva, Péter Csermely, Rhodes, Rogers, Sakharkar, Sergina, Stelling, Szathmary, Tamás Korcsmáros, Taniguchi, Tibor Vellai, Tortora, Urban, Wang, Xia, Yildirim, Zoltán Spiró   +65 more
core   +1 more source

The matricellular protein CCN3 regulates NOTCH1 signalling in chronic myeloid leukaemia [PDF]

, 2013
Deregulated NOTCH1 has been reported in lymphoid leukaemia, although its role in chronic myeloid leukaemia (CML) is not well established. We previously reported BCR-ABL down-regulation of a novel haematopoietic regulator, CCN3, in CML; CCN3 is a non ...
Crawford, Lisa J, Irvine, Alexandra E, Lu, Wan Hua, McCallum, Lynn, Sharpe, Daniel J, Suresh, Sukanya   +5 more
core   +1 more source

Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells [PDF]

Oncogene, 2019
AbstractTargeting Notch signaling has emerged as a promising therapeutic strategy for chronic lymphocytic leukemia (CLL), particularly inNOTCH1-mutated patients. We provide first evidence that the Notch ligand DLL4 is a potent stimulator of Notch signaling inNOTCH1-mutated CLL cells while increases cell proliferation.
Mónica López-Guerra, Sílvia Xargay-Torrent, Patricia Fuentes, Jocabed Roldán, Blanca González-Farré, Laia Rosich, Elisabeth Silkenstedt, María J. García-León, Eriong Lee-Vergés, Neus Giménez, Ariadna Giró, Marta Aymerich, Neus Villamor, Julio Delgado, Armando López-Guillermo, Xose S. Puente, Elias Campo, María L. Toribio, Dolors Colomer   +18 more
openaire   +5 more sources

His‐MMDM: Multi‐Domain and Multi‐Omics Translation of Histopathological Images with Diffusion Models

Advanced Science, EarlyView.
His‐MMDM is a diffusion model‐based framework for scalable multi‐domain and multi‐omics translation of histopathological images, enabling tasks from virtual staining, cross‐tumor knowledge transfer, and omics‐guided image editing. ABSTRACT Generative AI (GenAI) has advanced computational pathology through various image translation models.
Zhongxiao Li, Tianqi Su, Bin Zhang, Wenkai Han, Sibin Zhang, Guiyin Sun, Yuwei Cong, Xin Chen, Jiping Qi, Yujie Wang, Shiguang Zhao, Hongxue Meng, Peng Liang, Xin Gao   +13 more
wiley   +1 more source

Exosomal miR-182-5p from breast cancer cells reprogram tumor-associated macrophages and promote triple-negative breast cancer progression by targeting Notch1 in macrophages

Archives of Medical Science
Introduction The regulatory role of miR-182 in breast cancer malignancy and macrophage reprogramming is well established. However, the mechanisms through which miR-182 overexpression in tumor cells influences macrophage polarization remain elusive ...
Hongtao Li, Jingjing Fan, Jing Ma, Lei Qiao, Tong Sha, Binlin Ma   +5 more
doaj   +1 more source

An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma

Journal of Experimental & Clinical Cancer Research, 2019
Background Aberrant activation of Notch signaling has been causally linked to the metastasis of hepatocellular carcinoma (HCC), however the underlying molecular mechanisms are still poorly understood.
Lei Zhang, Jiewei Chen, Juanjuan Yong, Liang Qiao, Leibo Xu, Chao Liu   +5 more
doaj   +1 more source

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams-Oliver Syndrome With Variable Cardiac Anomalies. [PDF]

, 2015
BACKGROUND: Adams-Oliver syndrome (AOS) is a rare disorder characterized by congenital limb defects and scalp cutis aplasia. In a proportion of cases, notable cardiac involvement is also apparent.
Brancati, F, Coerdt, W, Collinson, CS, Dallapiccola, B, Digilio, MC, Graul-Neumann, LM, Jacquemin, E, Joss, S, Karountzos, ASV, Machado, RD, Ruddy, D, Salviati, L, Snape, KM, Southgate, L, Sukalo, M, Taylor, EJ, Tolmie, JL, Trembath, RC, Wuyts, W, Zenker, M   +19 more
core   +3 more sources

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

PLoS ONE, 2010
Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer as well as tumor angiogenesis, making Notch1 a potential therapeutic target.Here we report the in vitro ...
Aste-Amézaga, Miguel, Zhang, Ningyan, Lineberger, Janet E, Arnold, Beth A, Toner, Timothy J, Gu, Mingcheng, Huang, Lingyi, Vitelli, Salvatore, Vo, Kim T, Haytko, Peter, Zhao, Jing Zhang, Baleydier, Frédéric, L'Heureux, Sarah, Wang, Hongfang, Gordon, Wendy R, Thoryk, Elizabeth, Andrawes, Marie Blanke, Tiyanont, Kittichoat, Stegmaier, Kimberly, Roti, Giovanni, Ross, Kenneth N, Franlin, Laura L, Wang, Hui, Wang, Fubao, Chastain, Michael, Bett, Andrew J, Audoly, Laurent P, Aster, Jon C, Blacklow, Stephen C, Huber, Hans E   +29 more
openaire   +6 more sources