Notch3 in Development, Health and Disease [PDF]
Biomolecules, 2020 Notch3 is one of four mammalian Notch proteins, which act as signalling receptors to control cell fate in many developmental and adult tissue contexts.
Samira Hosseini-Alghaderi, Martin Baron
doaj +7 more sources
Computer identification of Notch3 in the neurogenic progenitor cells of mammalian early optic vesicles [PDF]
BMC Research NotesObjective The developing mammalian retina initially contains undifferentiated cells, providing a model for investigating the mechanisms of differentiation.
Yoshitoku Watabe +3 more
doaj +4 more sources
Reduced SUMOylation impairs NOTCH3 signaling and cell survival in the pathogenesis of CADASIL [PDF]
Cell Communication and SignalingCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary cerebral small vessel disease caused by NOTCH3 mutation.
Lijun Long +5 more
doaj +2 more sources
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. [PDF]
PLoS Genetics, 2014 The Notch3 signaling pathway is thought to play a critical role in cancer development, as evidenced by the Notch3 amplification and rearrangement observed in human cancers.
Jin-Gyoung Jung +7 more
doaj +4 more sources
Necessity of Notch3 signaling in myofiber maturation in a pluripotent stem cell transplant model [PDF]
Skeletal MuscleBackground Pluripotent stem cell-derived myogenic progenitors change from an embryonic to a postnatal molecular signature upon engrafting as satellite cells, which coincides with upregulation of Notch3.
Aline M. S. Yamashita +10 more
doaj +2 more sources
Extracellular domain shedding of NOTCH3 during endocytosis associated with heterogeneity between different CADASIL mutant activation mechanisms [PDF]
Cell Communication and SignalingBackground Mutations in NOTCH3 cause CADASIL, a dominantly inherited condition, linked to recurrent stroke and vascular dementia and associated with accumulation of the ECD of NOTCH3. The latter has a toxic effect on VSMCs.
Samira Hosseini-Alghaderi, Martin Baron
doaj +2 more sources
notch3 is essential for oligodendrocyte development and vascular integrity in zebrafish
Disease Models & Mechanisms, 2013 SUMMARY Mutations in the human NOTCH3 gene cause CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy).
Andreas Zaucker +4 more
doaj +2 more sources
Analyses of NOTCH3 variants in Chinese patients with clinically diagnosed Alzheimer's disease and frontotemporal dementia [PDF]
Alzheimer’s Research & TherapyBackground A pathogenic variant in the NOTCH3 gene has been identified as the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Studies focusing on variants in NOTCH3 in Alzheimer's disease (AD)
Haitian Nan +9 more
doaj +2 more sources
NOTCH3 CADASIL Variant Receptor Aggregation Requires NOTCH3 Wild-Type Receptors: Identification of Highly Selective Inhibitors That Block the Process. [PDF]
FASEB JCADASIL is the major cause of early‐onset stroke and cognitive dysfunction, including dementia. It is caused by mutations in the NOTCH3 receptor that result in the formation of protein aggregates in the small vessel walls of the brain. We demonstrated that NOTCH3 CADASIL variant receptor aggregation is strictly dependent on interactions with NOTCH3 ...
Wang H +9 more
europepmc +2 more sources