Results 21 to 30 of about 15,431 (206)

Use of antisense oligonucleotides to target Notch3 in skeletal cells.

PLoS ONE, 2022
Notch receptors are determinants of cell fate and function, and play an important role in the regulation of bone development and skeletal remodeling. Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variants ...
Ernesto Canalis, Michele Carrer, Tabitha Eller, Lauren Schilling, Jungeun Yu   +4 more
doaj   +2 more sources

Detection of Vascular Notch3 Deposits in Unfixed Frozen Skin Biopsy Sample in CADASIL

Frontiers in Neurology, 2022
This study aimed to evaluate the utility of immunohistochemical staining of vascular Notch3 deposits in biopsied unfixed frozen skin samples from patients with suspected cerebral autosomal dominant arteriopathy with subcortical infarcts and ...
Akihiko Ueda, Makoto Nakajima, Yohei Misumi, Keiichi Nakahara, Satoru Shinriki, Masayoshi Tasaki, Masayoshi Tasaki, Hirotaka Matsui, Mitsuharu Ueda   +8 more
doaj   +1 more source

Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. [PDF]

PLoS ONE, 2012
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is the best understood cause of dominantly inherited stroke and results from NOTCH3 mutations that lead to NOTCH3 protein accumulation and selective ...
He Meng, Xiaojie Zhang, Genggeng Yu, Soo Jung Lee, Y Eugene Chen, Igor Prudovsky, Michael M Wang   +6 more
doaj   +1 more source

The archetypal R90C CADASIL–NOTCH3 mutation retains NOTCH3 function in vivo [PDF]

Human Molecular Genetics, 2007
Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy (CADASIL) is the most prominent known cause of inherited stroke and vascular dementia in human adult. The disease gene, NOTCH3, encodes a transmembrane receptor primarily expressed in arterial smooth muscle cells (SMC).
Monet, M, Domenga, V, Lemaire, B, Souilhol, C, Langa, F, Babinet, C, Gridley, T, Tournier, Lasserve E, Cohen, Tannoudji M, Joutel, A   +9 more
openaire   +2 more sources

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

Cell Reports Medicine, 2021
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive.
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra   +22 more
doaj   +1 more source

NOTCH3 limits the epithelial–mesenchymal transition and predicts a favorable clinical outcome in esophageal cancer

Cancer Medicine, 2021
Background Esophageal squamous cell carcinoma (ESCC) is the deadliest of all human squamous cell carcinomas and is characterized by chemotherapy resistance and poor prognosis associated with the epithelial–mesenchymal transition (EMT).
Norihiro Matsuura, Koji Tanaka, Makoto Yamasaki, Kotaro Yamashita, Takuro Saito, Tomoki Makino, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Hiroshi Nakagawa, Yuichiro Doki   +12 more
doaj   +1 more source

Novel NOTCH3 alteration expanding the molecular spectrum of pericytic tumours: report of two cases. [PDF]

Histopathology
Introduction Myofibromas are part of the pericytic tumour family, which includes myopericytomas, glomus tumours and angioleiomyomas. While they typically display benign behaviour when arising in the skin and subcutaneous tissues of the head and neck, rare aggressive variants have been reported, particularly those with visceral or intracranial ...
Ungureanu IA, Le Quang M, Azmani R, Ancelle M, Margot H, Chotard G, Le Loarer F, Truffaux N.   +7 more
europepmc   +2 more sources

Expressions and Prognostic Values of Notch3 and DLL4 in Human Breast Cancer

Technology in Cancer Research & Treatment, 2023
Background : Notch signaling played a critical role in promoting breast tumorigenesis and progression. However, the role and prognostic value of Notch3 combined with DLL4 expression in breast carcinoma had not been explored.
Lin Wang, Ge Cao, Wei Li, Xiao-Wen Chen, Shi-Shuang Xiong, Ya-Nan Mu, Jin-Fang Jiang, Lan Yang, De-Rui Zhang, Yu-Wen Cao   +9 more
doaj   +1 more source

Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction

Neoplasia: An International Journal for Oncology Research, 2022
In multiple myeloma (MM), communication via Notch signaling in the tumor niche stimulates tumor progression and bone destruction. We previously showed that osteocytes activate Notch, increase Notch3 expression, and stimulate proliferation in MM cells. We
Hayley M. Sabol, Tânia Amorim, Cody Ashby, David Halladay, Judith Anderson, Meloney Cregor, Megan Sweet, Intawat Nookaew, Noriyoshi Kurihara, G. David Roodman, Teresita Bellido, Jesus Delgado-Calle   +11 more
doaj   +1 more source

Extensive Leukoencephalopathy in Spastic Paraplegia Type 4: Possible Role of Cerebral Autosomal Arteriopathy With Subcortical Infarcts and Leukoencephelopathy [PDF]

Journal of Movement Disorders, 2022
Despite recent advances in next-generation sequencing, the underlying etiology of adult-onset leukoencephalopathy has been difficult to elucidate. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a ...
Jin Ho Jung, Jung Hwa Seo, Sukyoon Lee, Young Jin Heo, Donghyun Kim, Eun Joo Chung, Seong-il Oh   +6 more
doaj   +1 more source