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Endocytic Trafficking of the Notch Receptor
Advances in Experimental Medicine and Biology, 2018The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation of the Notch receptor. Here, we will focus on its role during receptor degradation and describe the endosomal pathway with the components that are important for Notch degradation and the ...
Björn, Schnute +2 more
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Tugging on Notch receptor tunes signaling
Science, 2017Signal Transduction Notch proteins are transmembrane receptors that are important in the regulation of cell fate. They are unusual in that their ligands are membrane-bound on adjacent cells. Luca et al. provide insights into the signaling interactions between Notch and its various ligands.
L. Ray
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Structural Insights into Notch Receptor-Ligand Interactions
Advances in Experimental Medicine and Biology, 2018Pioneering cell aggregation experiments from the Artavanis-Tsakonas group in the late 1980's localized the core ligand recognition sequence in the Drosophila Notch receptor to epidermal growth factor-like (EGF) domains 11 and 12. Since then, advances in protein expression, structure determination methods and functional assays have enabled us to define ...
Penny A, Handford +4 more
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Notch receptors and hematopoiesis
Experimental Hematology, 2001Notch receptors are involved in a variety of cell-fate decisions that affect the development and function of many organs, including hematopoiesis and the immune system. There are four mammalian Notch receptors that have only partially overlapping functions despite sharing similar structures and ligands.
S, Kojika, J D, Griffin
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Notch receptor signal transduction
Experimental Hematology, 2000Abstract The Notch receptors participate in an evolutionarily conserved signaling pathway that regulates cell fate decisions. In hematopoiesis, Notch regulates T cell and B cell differentiation and may suppress differentiation of myeloid cells in vitro. Further, constitutive activation of Notch causes T-cell ALL in humans and mice.
L. Wu, J. Aster, J.D. Griffin
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Notch-1 and Notch-4 Receptors as Prognostic Markers in Breast Cancer
International Journal of Surgical Pathology, 2010Background: Studies looking at immunohistochemical (IHC) staining of Notch receptors in breast cancer and correlation with known prognostic factors are sparse. Methods: IHC staining for nuclear, cytoplasmic, and membrane Notch-1 (N1), Notch-4 (N4), and Jagged-1 (JAG1) was performed and correlated with known prognostic factors.
Yao K +6 more
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Notch-like Neurotrophin Receptor
Science Signaling, 2010A fragment of the p75 neurotrophin receptor appears to regulate transcription in the nucleus.
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The Notch-1 receptor in prostate tumorigenesis
Cancer Treatment Reviews, 2017The Notch signalling pathway plays a fundamental role in tissue development due to its involvement in cell fate determination and postnatal tissue differentiation. Its capacity to regulate cell growth and development has been linked to the occurrence of several cancers including that of the prostate.
Rebecca, O'Brien, Laure, Marignol
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Amyloid precursor protein interacts with notch receptors
Journal of Neuroscience Research, 2005The amyloid precursor protein (APP) must fulfill important roles based on its sequence conservation from fly to human. Although multiple functions for APP have been proposed, the best-known role for this protein is as the precursor of Abeta peptide, a neurotoxic 39-43-amino acid peptide crucial to the pathogenesis of Alzheimer's disease. To investigate
Sun Young, Oh +8 more
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