Results 51 to 60 of about 2,524,732 (339)

Mammalian NOTCH Receptor Activation and Signaling Protocols

, 2022
The NOTCH signaling pathway is one of the highly conserved key pathways involved in most cell differentiation and proliferation processes during both developmental and adult stages in most animals. The NOTCH signaling pathway appears to be very simple but the existence of several receptors and ligands, their posttranslational modifications, their ...
Nueda Sanz, María Luisa, Baladrón García, Victoriano   +1 more
openaire   +3 more sources

The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation*

Journal of Biological Chemistry, 2012
Background: Notch activity depends notably on the quantity of Notch receptor at the cell surface. Results: The ubiquitin-specific protease USP12 directly targets Notch and directs it to lysosomal degradation.
Julien Moretti, P. Chastagner, Chih-Chao Liang, M. Cohn, A. Israël, C. Brou   +5 more
semanticscholar   +1 more source

Notch Signaling in Breast Cancer: A Role in Drug Resistance

Cells, 2020
Breast cancer is a heterogeneous disease that can be subdivided into unique molecular subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor, and/or the Human Epidermal Growth Factor Receptor 2.
McKenna BeLow, Clodia Osipo
doaj   +1 more source

Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis. [PDF]

PLoS ONE, 2017
The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM). This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM. Protein O-
Rieko Ajima, Emiko Suzuki, Yumiko Saga
doaj   +1 more source

Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

Molecular Cancer, 2011
Background uPA/uPAR is a multifunctional system that is over expressed in many cancers and plays a critical role in glioblastoma (GBM) invasion. Previous studies from our lab have also shown that uPA/uPAR down regulation inhibits cancer cell invasion in ...
Gujrati Meena, Dinh Dzung H, Gondi Christopher S, Raghu Hari, Rao Jasti S   +4 more
doaj   +1 more source

Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer.

Cancer Research, 2011
Aberrant activation of the Notch receptor signaling pathway and overexpression of the Notch ligand JAG1 are associated with poor outcome in breast cancer.
Mamiko Shimizu, B. Cohen, P. Goldvasser, H. Berman, C. Virtanen, M. Reedijk   +5 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Angiopoietin-like proteins stimulate HSPC development through interaction with notch receptor signaling

eLife, 2015
Angiopoietin-like proteins (angptls) are capable of ex vivo expansion of mouse and human hematopoietic stem and progenitor cells (HSPCs). Despite this intriguing ability, their mechanism is unknown.
Michelle I Lin, Emily N Price, Sonja Boatman, Elliott J Hagedorn, Eirini Trompouki, Sruthi Satishchandran, Charles W Carspecken, Audrey Uong, Anthony DiBiase, Song Yang, Matthew C Canver, Ann Dahlberg, Zhigang Lu, Cheng Cheng Zhang, Stuart H Orkin, Irwin D Bernstein, Jon C Aster, Richard M White, Leonard I Zon   +18 more
doaj   +1 more source

Perivascular delivery of Notch 1 siRNA inhibits injury-induced arterial remodeling. [PDF]

PLoS ONE, 2014
To determine the efficacy of perivascular delivery of Notch 1 siRNA in preventing injury-induced arterial remodeling.Carotid artery ligation was performed to induce arterial remodeling. After 14 days, morphometric analysis confirmed increased vSMC growth
Eileen M Redmond, Weimin Liu, Katie Hamm, Ekaterina Hatch, Paul A Cahill, David Morrow   +5 more
doaj   +1 more source

Notch receptors in human choroid plexus tumors.

Histology and histopathology, 2013
Notch signaling plays a role in development and formation of the normal choroid plexus (nCP), and in formation of various tumors in humans. Activation of Notch3 has been reported to promote tumor growth in invasive gliomas and to initiate formation of choroid plexus tumors (CPT) in mice.
Waidelich, Johannes Maximilian, Schittenhelm, Jens Florian, Trautmann, Katrin, Beschorner, Rudi, Psaras, Tsambika   +4 more
openaire   +3 more sources