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Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer [PDF]
Frontiers in NutritionThe Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and microenvironment. The dual role of Notch signaling is significant. It can promote or inhibit cancer progression depending
Rong-Zu Nie +13 more
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Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask [PDF]
Cell Communication and SignalingBackground Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar +4 more
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Biological Significance of NOTCH Signaling Strength
Frontiers in Cell and Developmental Biology, 2021 The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
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Recent advances in in situ Notch signaling measurement
Frontiers in Cell and Developmental Biology, 2023 Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara +2 more
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The Notch signaling pathway: a potential target for cancer immunotherapy
Journal of Hematology & Oncology, 2023 Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription, and translation.
Xinxin Li +5 more
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Frontiers in Genetics, 2021 Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination contributes to Notch signaling regulation by governing the stability and activity of major signaling components.
Fengchao Zhang +3 more
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Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022 The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou +6 more
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To Be, or Notch to Be: Mediating Cell Fate from Embryogenesis to Lymphopoiesis
Biomolecules, 2021 Notch signaling forms an evolutionarily conserved juxtacrine pathway crucial for cellular development. Initially identified in Drosophila wing morphogenesis, Notch signaling has since been demonstrated to play pivotal roles in governing mammalian ...
Han Leng Ng +3 more
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Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells
Frontiers in Cell and Developmental Biology, 2022 Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and mechanosensitive Notch signaling are important regulators of vascular growth and remodeling.
Cansu Karakaya +12 more
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Notch Signaling in Leukemia [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2007 Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this ...
Jon C, Aster +2 more
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