Results 1 to 10 of about 190,719 (307)

Notch signaling pathway: architecture, disease, and therapeutics

Signal Transduction and Targeted Therapy, 2022
The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Kongming Wu, Qian Chu
exaly   +2 more sources

Interaction between Notch signaling pathway and bioactive compounds and its intervention on cancer [PDF]

Frontiers in Nutrition
The Notch signaling pathway is pivotal in cancer regulation, with its effects varying based on activation degree, tissue origin, and microenvironment. The dual role of Notch signaling is significant. It can promote or inhibit cancer progression depending
Rong-Zu Nie, Rong-Zu Nie, Hang Wang, Hang Wang, Shuang-Shuang Wang, Shuang-Shuang Wang, Huo-Min Luo, Huo-Min Luo, Chen Chen, Chen Chen, Zhao-Hui Jing, Zhao-Hui Jing, Pei-Feng Li, Pei-Feng Li   +13 more
doaj   +2 more sources

Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask [PDF]

Cell Communication and Signaling
Background Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar, Jyoti Singh, Dipti Verma, Mousumi Mutsuddi, Ashim Mukherjee   +4 more
doaj   +2 more sources

Competition in notch signaling with cis enriches cell fate decisions. [PDF]

PLoS ONE, 2014
Notch signaling is involved in cell fate choices during the embryonic development of Metazoa. Commonly, Notch signaling arises from the binding of the Notch receptor to its ligands in adjacent cells driving cell-to-cell communication.
Pau Formosa-Jordan, Marta Ibañes
doaj   +5 more sources

Notch signaling in cancers: mechanism and potential therapy [PDF]

Frontiers in Cell and Developmental Biology
The Notch signaling pathway is an evolutionarily conserved intercellular signaling cascade that regulates a number of cellular processes, including cell development, proliferation, apoptosis, and genome stability. The Notch signaling pathway is pervasive
Chen Chen, Yan Du, Rongzu Nie, Shuangshuang Wang, Hang Wang, Peifeng Li   +5 more
doaj   +2 more sources

Biological Significance of NOTCH Signaling Strength

Frontiers in Cell and Developmental Biology, 2021
The evolutionarily conserved NOTCH signaling displays pleotropic functions in almost every organ system with a simple signaling axis. Different from many other signaling pathways that can be amplified via kinase cascades, NOTCH signaling does not contain
Wei Shen, Jiaxin Huang, Yan Wang
doaj   +1 more source

Recent advances in in situ Notch signaling measurement

Frontiers in Cell and Developmental Biology, 2023
Notch signaling is necessary for the development of many organ systems, including the nervous system, biliary system, and visual and auditory sensory systems. This signaling pathway is composed of DSL ligands and Notch receptors.
Masaharu Yoshihara, Satoru Takahashi, Satoru Takahashi   +2 more
doaj   +1 more source

The Notch signaling pathway: a potential target for cancer immunotherapy

Journal of Hematology & Oncology, 2023
Dysregulation of the Notch signaling pathway, which is highly conserved across species, can drive aberrant epigenetic modification, transcription, and translation.
Xinxin Li, Xianchun Yan, Yufeng Wang, Balveen Kaur, Hua Han, Jianhua Yu   +5 more
doaj   +1 more source

The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation During Drosophila Wing Development

Frontiers in Genetics, 2021
Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination contributes to Notch signaling regulation by governing the stability and activity of major signaling components.
Fengchao Zhang, Yao Chen, Jie Shen, Junzheng Zhang   +3 more
doaj   +1 more source

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells

Frontiers in Cell and Developmental Biology, 2022
Mechanical stimuli experienced by vascular smooth muscle cells (VSMCs) and mechanosensitive Notch signaling are important regulators of vascular growth and remodeling.
Cansu Karakaya, Cansu Karakaya, Mark C. van Turnhout, Valery L. Visser, Tommaso Ristori, Tommaso Ristori, Carlijn V. C. Bouten, Carlijn V. C. Bouten, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Cecilia M. Sahlgren, Sandra Loerakker, Sandra Loerakker   +12 more
doaj   +1 more source