Results 41 to 50 of about 190,719 (307)
NOTCH Signaling in T-Cell-Mediated Anti-Tumor Immunity and T-Cell-Based Immunotherapies
Frontiers in Immunology, 2018 The NOTCH (1–4) family of receptors are highly conserved and are critical in regulating many developmental processes and in the maintenance of tissue homeostasis.
Michelle A. Kelliher +1 more
doaj +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases. [PDF]
, 2016 Notch is a key player in various developmental processes during the embryonic stage as well as in regulating tissue homeostasis, cell differentiation, and stem cell maintenance in adult life.
Dela Golshayan +6 more
core +1 more source
Notch Ligand Binding Assay Using Flow Cytometry
Bio-Protocol, 2017 Notch signaling is an evolutionarily conserved signaling pathway that plays an indispensable role during development, and in the maintenance of homeostatic processes, in a wide variety of tissues (Kopan, 2012; Hori et al., 2013).
Shweta Varshney, Pamela Stanley
doaj +1 more source
Biomolecules, 2022 Endoplasmic reticulum (ER) stress activated in granulosa cells contributes to the pathophysiology of polycystic ovary syndrome (PCOS). In addition, recent studies have demonstrated that Notch signaling plays multiple roles in the ovary via cell-to-cell ...
Hiroshi Koike +12 more
doaj +1 more source
Notch Signaling and T-Helper Cells in EAE/MS [PDF]
, 2013 The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Bassil, Ribal +2 more
core +3 more sources
Role of Notch signaling in the mammalian heart
Brazilian Journal of Medical and Biological Research, 2014 Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical
X.L. Zhou, J.C. Liu
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Notch Signaling Mediates Secondary Senescence [PDF]
Cell Reports, 2019 Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints.
Teo, Yee Voan +14 more
openaire +5 more sources
The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation
Biomolecules, 2021 Aberrant Notch signaling has been found in a broad range of human malignancies. Consequently, small molecule inhibitors and antibodies targeting Notch signaling in human cancers have been developed and tested; however, these have failed due to limited ...
Judith Hounjet, Marc Vooijs
doaj +1 more source
The molecular basis of T cell acute lymphoblastic leukemia [PDF]
, 2012 T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando +23 more
core +1 more source