Results 51 to 60 of about 190,719 (307)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

A role for actomyosin contractility in Notch signaling

BMC Biology, 2019
Background Notch-Delta signaling functions across a wide array of animal systems to break symmetry in a sheet of undifferentiated cells and generate cells with different fates, a process known as lateral inhibition.
Ginger L. Hunter, Li He, Norbert Perrimon, Guillaume Charras, Edward Giniger, Buzz Baum   +5 more
doaj   +1 more source

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation [PDF]

, 2018
Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes ...
Bevilacqua, Valeria, Caffarelli, Elisa, De Jaco, Antonella, Di Bari, Maria, Laneve, Pietro, Piovesana, Roberta, Talora, Claudio, Tata, Ada Maria, Trobiani, Laura   +8 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Notch signaling regulates adipose browning and energy metabolism [PDF]

, 2014
Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in WAT browning would raise energy expenditure and reduce adiposity.
Bi, Pengpeng, Carlesso, Nadia, Kuang, Shihuan, Li, Jie, Liang, Xin-Rong, Liu, Weiyi, Liu, Xiaoqi, Shan, Tizhong, Wang, Jinghua, Yang, Xin, Yue, Feng   +10 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

MPDZ promotes DLL4-induced Notch signaling during angiogenesis

eLife, 2018
Angiogenesis is coordinated by VEGF and Notch signaling. DLL4-induced Notch signaling inhibits tip cell formation and vessel branching. To ensure proper Notch signaling, receptors and ligands are clustered at adherens junctions.
Fabian Tetzlaff, M Gordian Adam, Anja Feldner, Iris Moll, Amitai Menuchin, Juan Rodriguez-Vita, David Sprinzak, Andreas Fischer   +7 more
doaj   +1 more source

Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. [PDF]

PLoS Genetics, 2014
Stem cells have an innate ability to occupy their stem cell niche, which in turn, is optimized to house stem cells. Organ aging is associated with reduced stem cell occupancy in the niche, but the mechanisms involved are poorly understood.
Chen-Yuan Tseng, Shih-Han Kao, Chih-Ling Wan, Yueh Cho, Shu-Yun Tung, Hwei-Jan Hsu   +5 more
doaj   +1 more source

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling [PDF]

, 2016
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding
A Djiane, A Ghysen, A Krejci, A Krejci, A Rogulja-Ortmann, A Schmid, AC Nagel, AM Bailey, B Kahali, B Kramatschek, B Pfeuty, BA Edgar, BE Housden, BE Housden, C Bivik, C Delidakis, C Peterson, C Ulvklo, CA Meyer, Caroline Bivik, CQ Doe, CQ Doe, CQ Doe, D Karlsson, D Karolchik, D Pan, DA Lehman, DF Poulson, E Knust, E Wurmbach, EC Lai, EC Lai, EP Spana, Erika Gunnar, F Liu, Francois Schweisguth, H Schmidt, H Schrons, I Miguel-Aliaga, I Rebay, I Wech, J Bischof, J Culi, J Hirata, JA Knoblich, JB Skeath, JB Skeath, JF de Celis, JL Cooper, JQ Boone, K Hori, K White, Khalil Mazouni, KJ Venken, L Jones, L Li, M Baumgardt, M Baumgardt, M Kohwi, M Lecourtois, MJ Lundell, MJ Vogel, N Giagtzoglou, O Birkholz, P Ligoxygakis, Paul H. Taghert, R Kageyama, R Kannan, R Karcavich, R Kopan, R Kopan, R Kushwah, R Lehmann, R Urbach, RL Trott, Ryan B. MacDonald, S Chanet, S Higashijima, S Yamamoto, SL Lai, SP Choksi, Stefan Thor, T Novotny, T Tsuji, TH Liu, UC Karandikar, YN Jan, Z Wang, Z Wang   +88 more
core   +5 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source