Results 81 to 90 of about 190,719 (307)
A genetic mosaic screen identifies genes modulating Notch signaling in Drosophila. [PDF]
PLoS ONE, 2018 Notch signaling is conserved in most multicellular organisms and plays critical roles during animal development. The core components and major signal transduction mechanism of Notch signaling have been extensively studied.
Luming Ren +6 more
doaj +1 more source
Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. [PDF]
, 2017 Glioblastoma (GBM) stem cells (GSCs) reside in both hypoxic and vascular microenvironments within tumors. The molecular mechanisms that allow GSCs to occupy such contrasting niches are not understood.
Barcellos-Hoff, Mary Helen +20 more
core +1 more source
Genomic control of patterning [PDF]
, 2009 The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome.
Davidson, Eric H., Peter, Isabelle S.
core +2 more sources
Functional Connectivity Linked to Cognitive Recovery After Minor Stroke
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri +7 more
wiley +1 more source
The Challenge of Targeting Notch in Hematologic Malignancies
Frontiers in Pediatrics, 2014 Notch signaling can play oncogenic and tumor suppressor roles depending on cell type. Hematologic malignancies encompass a wide range of transformed cells, and consequently the roles of Notch are diverse in these diseases. For example Notch is a potent T
Fiorela N Hernandez Tejada +2 more
doaj +1 more source
Notch signaling is associated with ALDH activity and an aggressive metastatic phenotype in murine osteosarcoma cells [PDF]
, 2013 Osteosarcoma (OS) is the most common primary malignancy of bone, and pulmonary metastatic disease accounts for nearly all mortality. However, little is known about the biochemical signaling alterations that drive the progression of metastatic disease ...
Greco, N +4 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
Involvement of notch signaling in wound healing. [PDF]
PLoS ONE, 2007 The Notch signaling pathway is critically involved in cell fate decisions during development of many tissues and organs. In the present study we employed in vivo and cell culture models to elucidate the role of Notch signaling in wound healing.
Srinivasulu Chigurupati +14 more
doaj +1 more source
Glycosylated notch and cancer [PDF]
, 2016 Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development.
Couto, Africa +3 more
core +1 more source
Micropatterned Biphasic Printed Electrodes for High‐Fidelity on‐Skin Bioelectronics
Advanced Functional Materials, EarlyView.Micropatterned biphasic printed electrodes achieve unprecedented skin conformity and low impedance by combining liquid‐metal droplets with microstructured 3D lattices. This scalable approach enables high‐fidelity detection of ECG, EMG, and EEG signals, including alpha rhythms from the forehead, with long‐term comfort and stability.
Manuel Reis Carneiro +4 more
wiley +1 more source