Results 1 to 10 of about 152,934 (201)

Notch signaling pathway: architecture, disease, and therapeutics

Signal Transduction and Targeted Therapy, 2022
The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou, Wanling Lin, Yaling Long, Yunkai Yang, Huan Zhang, Kongming Wu, Qian Chu   +6 more
doaj   +5 more sources

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies [PDF]

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
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The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress [PDF]

Frontiers in Immunology
This article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biological ...
Haokun Zhang, Haokun Zhang, Haokun Zhang, Wang Hang, Wang Hang, Wang Hang, ZhaoHui Jing, ZhaoHui Jing, ZhaoHui Jing, Bingyan Liu, Bingyan Liu, Bingyan Liu, Xiaoxiao Wang, Xiaoxiao Wang, Xiaoxiao Wang, Yilin Li, Yilin Li, Yilin Li, Huomin Luo, Huomin Luo, Huomin Luo, Huilin Lv, Huilin Lv, Huilin Lv, Xingyue Tao, Xingyue Tao, Xingyue Tao, Peter Timashev, Yuzhen Li, Peifeng Li, Peifeng Li, Peifeng Li   +31 more
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Notch signaling pathway and heart development, congenital heart disease, and myocardial regeneration [PDF]

Frontiers in Bioengineering and Biotechnology
This review summarizes the critical role of the Notch signaling pathway in cardiac development, congenital heart disease, and myocardial regeneration.
Yaping Liu, Yaping Liu, Yaping Liu, Xiaoxiao Wang, Xiaoxiao Wang, Xiaoxiao Wang, Xingyue Tao, Xingyue Tao, Xingyue Tao, Hao-Kun Zhang, Hao-Kun Zhang, Hao-Kun Zhang, Bingyan Liu, Bingyan Liu, Bingyan Liu, Yilin Li, Yilin Li, Yilin Li, Hang Wang, Hang Wang, Hang Wang, Huo-Min Luo, Huo-Min Luo, Huo-Min Luo, Hui-Lin Lv, Hui-Lin Lv, Hui-Lin Lv, Peifeng Li, Peifeng Li, Peifeng Li   +29 more
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Role of the Notch signaling pathway in porcine oocyte maturation [PDF]

Cell Communication and Signaling
Background Although the Notch signaling pathway is known to play an important role in ovarian follicle development in mammals, whether it is involved in oocyte maturation remains unclear. Therefore, this study was performed to elucidate the existence and
Pil-Soo Jeong, Hyo-Gu Kang, Dabin Cha, Se-Been Jeon, Min Ju Kim, Bong-Seok Song, Bo-Woong Sim, Sanghoon Lee   +7 more
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Research Advances in Myocardial Infarction Repair and Cardiac Regenerative Medicine via the Notch Signaling Pathway [PDF]

Reviews in Cardiovascular Medicine
Acute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia in the coronary artery and severely affects public health.
Songyan Cai, Qingyuan Dai
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Implications of notch signaling in duchenne muscular dystrophy

Frontiers in Physiology, 2022
This review focuses upon the implications of the Notch signaling pathway in muscular dystrophies, particularly Duchenne muscular dystrophy (DMD): a pervasive and catastrophic condition concerned with skeletal muscle degeneration.
Lily Den Hartog, Atsushi Asakura
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Notch Signaling Pathway Is Activated by Sulfate Reducing Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
Sulfate Reducing Bacteria (SRB), usually rare residents of the gut, are often found in increased numbers (called a SRB bloom) in inflammatory conditions such as Inflammatory Bowel Disease (IBD), pouchitis, and periodontitis.
Sudha B. Singh, Cristina N. Coffman, Amanda Carroll-Portillo, Matthew G. Varga, Henry C. Lin, Henry C. Lin   +5 more
doaj   +1 more source

Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity.

PLoS ONE, 2021
Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression, drug resistance and tumor recurrence. We have recently shown that the Notch pathway determines the tumor-regulatory role of experimentally created 'CAFs'.
Hongwei Shao, Mecker Moller, Long Cai, Rochelle Prokupets, Cuixia Yang, Connor Costa, Kerstin Yu, Nga Le, Zhao-Jun Liu   +8 more
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Activation of the Notch signaling pathway promotes neurovascular repair after traumatic brain injury

Neural Regeneration Research, 2015
The Notch signaling pathway plays a key role in angiogenesis and endothelial cell formation, but it remains unclear whether it is involved in vascular repair by endothelial progenitor cells after traumatic brain injury.
Qi-shan Ran, Yun-hu Yu, Xiao-hong Fu, Yuan-chao Wen   +3 more
doaj   +1 more source