Results 1 to 10 of about 156,347 (208)

Notch Signaling and T-Helper Cells in EAE/MS [PDF]

Clinical and Developmental Immunology, 2013
The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch emerging as a key player in ...
Ribal Bassil, William Orent, Wassim Elyaman   +2 more
doaj   +4 more sources

The role of notch signaling pathway in cancer: mechanistic insights, therapeutic potential, and clinical progress [PDF]

Frontiers in Immunology
This article presents a comprehensive literature review on the role of the Notch signaling pathway in cancer and its molecular mechanisms. The Notch signaling pathway plays an important role in various types of cancer by regulating key biological ...
Haokun Zhang, Haokun Zhang, Haokun Zhang, Wang Hang, Wang Hang, Wang Hang, ZhaoHui Jing, ZhaoHui Jing, ZhaoHui Jing, Bingyan Liu, Bingyan Liu, Bingyan Liu, Xiaoxiao Wang, Xiaoxiao Wang, Xiaoxiao Wang, Yilin Li, Yilin Li, Yilin Li, Huomin Luo, Huomin Luo, Huomin Luo, Huilin Lv, Huilin Lv, Huilin Lv, Xingyue Tao, Xingyue Tao, Xingyue Tao, Peter Timashev, Yuzhen Li, Peifeng Li, Peifeng Li, Peifeng Li   +31 more
doaj   +2 more sources

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies [PDF]

Signal Transduction and Targeted Therapy
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution.
Qingmiao Shi, Chen Xue, Yifan Zeng, Xin Yuan, Qingfei Chu, Shuwen Jiang, Jinzhi Wang, Yaqi Zhang, Danhua Zhu, Lanjuan Li   +9 more
doaj   +2 more sources

Role of the Notch signaling pathway in porcine oocyte maturation [PDF]

Cell Communication and Signaling
Background Although the Notch signaling pathway is known to play an important role in ovarian follicle development in mammals, whether it is involved in oocyte maturation remains unclear. Therefore, this study was performed to elucidate the existence and
Pil-Soo Jeong, Hyo-Gu Kang, Dabin Cha, Se-Been Jeon, Min Ju Kim, Bong-Seok Song, Bo-Woong Sim, Sanghoon Lee   +7 more
doaj   +2 more sources

Research Advances in Myocardial Infarction Repair and Cardiac Regenerative Medicine via the Notch Signaling Pathway [PDF]

Reviews in Cardiovascular Medicine
Acute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia in the coronary artery and severely affects public health.
Songyan Cai, Qingyuan Dai
doaj   +2 more sources

Correction: Ma et al. Effects of Probiotic-Fermented Deer Bone Water Extract on Immune Regulation and Gut Microbiota in Rheumatoid Arthritis via the NOTCH Signaling Pathway. Foods 2025, 14, 3802. [PDF]

Foods
Ma J, Jiang Y, Teng Y, Ren T, Xing Y, Li A, He Z, Chen W, Zong Y, Du R.   +9 more
europepmc   +3 more sources

Implications of notch signaling in duchenne muscular dystrophy

Frontiers in Physiology, 2022
This review focuses upon the implications of the Notch signaling pathway in muscular dystrophies, particularly Duchenne muscular dystrophy (DMD): a pervasive and catastrophic condition concerned with skeletal muscle degeneration.
Lily Den Hartog, Atsushi Asakura
doaj   +1 more source

Notch signaling pathway: architecture, disease, and therapeutics

Signal Transduction and Targeted Therapy, 2022
The NOTCH gene was identified approximately 110 years ago. Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription
Binghan Zhou, Wanling Lin, Yaling Long, Yunkai Yang, Huan Zhang, Kongming Wu, Qian Chu   +6 more
doaj   +1 more source

Notch Signaling Pathway Is Activated by Sulfate Reducing Bacteria

Frontiers in Cellular and Infection Microbiology, 2021
Sulfate Reducing Bacteria (SRB), usually rare residents of the gut, are often found in increased numbers (called a SRB bloom) in inflammatory conditions such as Inflammatory Bowel Disease (IBD), pouchitis, and periodontitis.
Sudha B. Singh, Cristina N. Coffman, Amanda Carroll-Portillo, Matthew G. Varga, Henry C. Lin, Henry C. Lin   +5 more
doaj   +1 more source

Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity.

PLoS ONE, 2021
Cancer-associated fibroblasts (CAFs) play a crucial role in cancer progression, drug resistance and tumor recurrence. We have recently shown that the Notch pathway determines the tumor-regulatory role of experimentally created 'CAFs'.
Hongwei Shao, Mecker Moller, Long Cai, Rochelle Prokupets, Cuixia Yang, Connor Costa, Kerstin Yu, Nga Le, Zhao-Jun Liu   +8 more
doaj   +1 more source