Results 31 to 40 of about 156,496 (347)
Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. [PDF]
PLoS ONE, 2012 BACKGROUND:Notch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both ...
Gengqiang Xie +6 more
doaj +1 more source
Notch signalling pathway in development of cholangiocarcinoma
World Journal of Gastrointestinal Oncology, 2020 Cholangiocarcinoma (CCA) comprises of extra-hepatic cholangiocarcinoma and intrahepatic cholangiocarcinoma cancers as a result of inflammation of epithelium cell lining of the bile duct. The incidence rate is increasing dramatically worldwide with highest rates in Eastern and South Asian regions.
Rauff, Bisma +5 more
openaire +2 more sources
Clinical and Experimental Obstetrics & Gynecology, 2023 Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
doaj +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
Notch signaling pathway and gastric cancer
World Chinese Journal of Digestology, 2015 Ying-Cheng Zhang +5 more
openalex +2 more sources
Role of Notch signaling in the mammalian heart
Brazilian Journal of Medical and Biological Research, 2014 Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical
X.L. Zhou, J.C. Liu
doaj +1 more source
Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]
, 2011 Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny +6 more
core +1 more source
Role of notch signaling pathway in Muc5ac secretion induced by atmospheric PM2.5 in rats
Ecotoxicology and Environmental Safety, 2022 Background: The secretion of Muc5ac is closely related to the pathogenesis, treatment and prognosis of bronchial asthma. Atmospheric PM2.5 entered the airway can irritate and corrode the bronchial wall, affecting the expression and secretion of Muc5ac ...
Ying Liu +5 more
doaj +1 more source
Notch signaling is associated with ALDH activity and an aggressive metastatic phenotype in murine osteosarcoma cells [PDF]
, 2013 Osteosarcoma (OS) is the most common primary malignancy of bone, and pulmonary metastatic disease accounts for nearly all mortality. However, little is known about the biochemical signaling alterations that drive the progression of metastatic disease ...
Greco, N +4 more
core +2 more sources
The Notch Regulator Numb Links the Notch and TCR Signaling Pathways [PDF]
The Journal of Immunology, 2005 Abstract Both the Notch and TCR signaling pathways play an important role in T cell development, but the links between these signaling pathways are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of Notch and also contains a phosphotyrosine binding domain, suggesting that Numb could provide a link between ...
Ana C, Anderson +6 more
openaire +2 more sources