Results 31 to 40 of about 152,934 (201)

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells [PDF]

, 2004
Introduction Notch signaling has been implicated in the regulation of cell-fate decisions such as self-renewal of adult stem cells and differentiation of progenitor cells along a particular lineage. Moreover, depending on the cellular and
IL Weissman, T Reya, GH Smith, G Dontu, BA Reynolds, L Miele, S Artavanis-Tsakonas, H Qi, L Li, E Six, T Kadesch, G Smith, H Uyttendaele, JV Soriano, A Diévart, K Brennan, J Stingl, VM Weaver, T Shimazaki, SJ Morrison, JS Mumm, S Jarriault, PS Rudland, D Nofziger, BJ Nickoloff, K Tanigaki, T Gudjonsson, S Weijzen, SJ Morrison, IL Weissman, L Krebs, K Siziopikou, A Imantani, K Fitzgerald, A Rangarajan, P Zagouras, F Radtke, H Uyttendaele, M Al-Hajj, G Dontu   +39 more
core   +3 more sources

Uif, a large transmembrane protein with EGF-like repeats, can antagonize Notch signaling in Drosophila. [PDF]

PLoS ONE, 2012
BACKGROUND:Notch signaling is a highly conserved pathway in multi-cellular organisms ranging from flies to humans. It controls a variety of developmental processes by stimulating the expression of its target genes in a highly specific manner both ...
Gengqiang Xie, Hongtao Zhang, Guiping Du, Qinglei Huang, Xuehong Liang, Jun Ma, Renjie Jiao   +6 more
doaj   +1 more source

Study of the Notch-Aromatic Hydrocarbon Receptor-Interleukin-22 Signaling Pathway and the Pathogenesis of Immune Thrombocytopenia

Clinical and Experimental Obstetrics & Gynecology, 2023
Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms ...
Qian-qian Fan, Rong-xia He
doaj   +1 more source

Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling [PDF]

, 2016
The Notch pathway controls proliferation during development and in adulthood, and is frequently affected in many disorders. However, the genetic sensitivity and multi-layered transcriptional properties of the Notch pathway has made its molecular decoding
A Djiane, A Ghysen, A Krejci, A Krejci, A Rogulja-Ortmann, A Schmid, AC Nagel, AM Bailey, B Kahali, B Kramatschek, B Pfeuty, BA Edgar, BE Housden, BE Housden, C Bivik, C Delidakis, C Peterson, C Ulvklo, CA Meyer, Caroline Bivik, CQ Doe, CQ Doe, CQ Doe, D Karlsson, D Karolchik, D Pan, DA Lehman, DF Poulson, E Knust, E Wurmbach, EC Lai, EC Lai, EP Spana, Erika Gunnar, F Liu, Francois Schweisguth, H Schmidt, H Schrons, I Miguel-Aliaga, I Rebay, I Wech, J Bischof, J Culi, J Hirata, JA Knoblich, JB Skeath, JB Skeath, JF de Celis, JL Cooper, JQ Boone, K Hori, K White, Khalil Mazouni, KJ Venken, L Jones, L Li, M Baumgardt, M Baumgardt, M Kohwi, M Lecourtois, MJ Lundell, MJ Vogel, N Giagtzoglou, O Birkholz, P Ligoxygakis, Paul H. Taghert, R Kageyama, R Kannan, R Karcavich, R Kopan, R Kopan, R Kushwah, R Lehmann, R Urbach, RL Trott, Ryan B. MacDonald, S Chanet, S Higashijima, S Yamamoto, SL Lai, SP Choksi, Stefan Thor, T Novotny, T Tsuji, TH Liu, UC Karandikar, YN Jan, Z Wang, Z Wang   +88 more
core   +5 more sources

Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]

, 2018
The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana, Campese, Antonio Francesco, Felli, MARIA PIA, Ferrandino, Francesca, Grazioli, Paola, Screpanti, Isabella   +5 more
core   +2 more sources

Role of Notch signaling in the mammalian heart

Brazilian Journal of Medical and Biological Research, 2014
Notch signaling is an evolutionarily ancient, highly conserved pathway important for deciding cell fate, cellular development, differentiation, proliferation, apoptosis, adhesion, and epithelial-to-mesenchymal transition. Notch signaling is also critical
X.L. Zhou, J.C. Liu
doaj   +1 more source

Role of notch signaling pathway in Muc5ac secretion induced by atmospheric PM2.5 in rats

Ecotoxicology and Environmental Safety, 2022
Background: The secretion of Muc5ac is closely related to the pathogenesis, treatment and prognosis of bronchial asthma. Atmospheric PM2.5 entered the airway can irritate and corrode the bronchial wall, affecting the expression and secretion of Muc5ac ...
Ying Liu, Liting Zhou, Hanlin Wu, Yitong Wang, Danzengluobu, Bo Zhang   +5 more
doaj   +1 more source

The Notch Regulator Numb Links the Notch and TCR Signaling Pathways [PDF]

The Journal of Immunology, 2005
Abstract Both the Notch and TCR signaling pathways play an important role in T cell development, but the links between these signaling pathways are largely unexplored. The adapter protein Numb is a well-characterized inhibitor of Notch and also contains a phosphotyrosine binding domain, suggesting that Numb could provide a link between ...
Ana C, Anderson, Elizabeth A, Kitchens, Shiao Wei, Chan, Charles, St Hill, Yuh Nung, Jan, Weimin, Zhong, Ellen A, Robey   +6 more
openaire   +2 more sources

Interactions between fibroblast growth factors and Notch regulate neuronal differentiation [PDF]

, 2001
The differentiation of precursor cells into neurons has been shown to be influenced by both the Notch signaling pathway and growth factor stimulation.
Bartlett, PF, Cappai, R, Epa, R, Faux, CH, Turnley, AM   +4 more
core   +1 more source

Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells

Kaohsiung Journal of Medical Sciences, 2019
Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj   +1 more source