Notch signaling is associated with ALDH activity and an aggressive metastatic phenotype in murine osteosarcoma cells [PDF]
, 2013 Osteosarcoma (OS) is the most common primary malignancy of bone, and pulmonary metastatic disease accounts for nearly all mortality. However, little is known about the biochemical signaling alterations that drive the progression of metastatic disease ...
Greco, N +4 more
core +2 more sources
Essential gene pathways for glioblastoma stem cells: clinical implications for prevention of tumor recurrence. [PDF]
, 2011 Glioblastoma (World Health Organization/WHO grade IV) is the most common and most aggressive adult glial tumor. Patients with glioblastoma, despite being treated with gross total resection and post-operative radiation/chemotherapy, will almost always ...
Choe, Jinny +6 more
core +1 more source
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]
, 2017 Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio +4 more
core +1 more source
Association between Notch signaling pathway and cancer
Acta Medica Lituanica, 2013 Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and differentiation.
Nadežda Lachej +4 more
doaj +1 more source
The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Notch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC).
Jonas Ungerbäck +4 more
doaj +1 more source
Active Notch signaling is required for arm regeneration in a brittle star.
PLoS ONE, 2020 Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including ...
Vladimir Mashanov +7 more
doaj +1 more source
The Notch signalling pathway in hair growth
Mechanisms of Development, 1998 The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role.
Powell, B. +3 more
openaire +3 more sources
Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]
, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen +6 more
core +2 more sources
Cellular Physiology and Biochemistry, 2015 Background: The Notch signaling pathway is implicated in a broad range of developmental processes, including cell fate decisions. This study was designed to determine the role of Notch signaling in adipogenic differentiation of human bone marrow derived ...
Bao-quan Song +12 more
doaj +1 more source
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode [PDF]
, 2008 The inner ear derives from a patch of ectoderm defined by expression of the transcription factor Pax2. We recently showed that this Pax2^+ ectoderm gives rise not only to the otic placode but also to the surrounding cranial epidermis, and that Wnt ...
Groves, Andrew K. +3 more
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