Kaohsiung Journal of Medical Sciences, 2019 Radiation therapy is the primary treatment for primary nasopharyngeal carcinoma (NPC). The aim of this study is to identify the effect of the Numb/Notch signaling pathway on radiation sensitivity in human NPC cells.
Er‐Dong Shen, Qiang Zeng
doaj +1 more source
Interactions between fibroblast growth factors and Notch regulate neuronal differentiation [PDF]
, 2001 The differentiation of precursor cells into neurons has been shown to be influenced by both the Notch signaling pathway and growth factor stimulation.
Bartlett, PF +4 more
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The Notch-2 gene is regulated by Wnt signaling in cultured colorectal cancer cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Notch and Wnt pathways are key regulators of intestinal homeostasis and alterations in these pathways may lead to the development of colorectal cancer (CRC).
Jonas Ungerbäck +4 more
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An updated evolutionary study of the Notch family reveals a new ancient origin and novel invariable motifs as potential pharmacological targets [PDF]
PeerJ, 2020 Notch family proteins play a key role in a variety of developmental processes by controlling cell fate decisions and operating in a great number of biological processes in several organ systems, such as hematopoiesis, somatogenesis, vasculogenesis ...
Dimitrios Vlachakis +5 more
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Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]
, 2016 BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen +6 more
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Association between Notch signaling pathway and cancer
Acta Medica Lituanica, 2013 Background. The components of the Notch signaling pathway are important in maintaining the balance involved in cell proliferation, apoptosis and differentiation.
Nadežda Lachej +4 more
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Active Notch signaling is required for arm regeneration in a brittle star.
PLoS ONE, 2020 Cell signaling pathways play key roles in coordinating cellular events in development. The Notch signaling pathway is highly conserved across all multicellular animals and is known to coordinate a multitude of diverse cellular events, including ...
Vladimir Mashanov +7 more
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PEAR1 Promotes Myoblast Proliferation Through Notch Signaling Pathway. [PDF]
Biology (Basel)PEAR1, also known as platelet endothelial aggregation receptor 1, is known to play a crucial role in the migration and differentiation of muscle satellite cells (MuSCs). However, its specific effects on skeletal muscle development and regeneration require further exploration.
Zhao Y +7 more
europepmc +4 more sources
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB [PDF]
, 2017 Purpose: Cancer stem cells (CSC) are self-renewing tumor cells, with the ability to generate diverse differentiated tumor cell subpopulations. They differ from normal stem cells in the deregulation of the mechanisms that normally control stem cell ...
Carnero Moya, Amancio +4 more
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The Notch signalling pathway in hair growth
Mechanisms of Development, 1998 The Notch signalling pathway is an important mediator of cell fate selection whose involvement in epidermal appendage formation is now becoming recognised. Hair follicle development and hair formation involve the co-ordinated differentiation of several different cell types in which Notch appears to have a role.
Powell, B. +3 more
openaire +3 more sources