Results 71 to 80 of about 152,934 (201)

Current research of the Notch pathway in hepatocellular carcinoma

European Journal of Medical Research
Notch signaling is a widely preserved communication pathway that supports essential cellular functions by allowing adjacent cells to interact. The Notch signaling pathway consists of Notch ligands (DSL proteins), Notch receptors, DNA-binding proteins ...
Leiya Fu, Xinyu Gu, Na Lou, Juan Li, Chen Xue   +4 more
doaj   +1 more source

Post-Developmental Roles of Notch Signaling in the Nervous System

Biomolecules, 2020
Since its discovery in Drosophila, the Notch signaling pathway has been studied in numerous developmental contexts in diverse multicellular organisms. The role of Notch signaling in nervous system development has been extensively investigated by numerous
Jose L. Salazar, Sheng-An Yang, Shinya Yamamoto   +2 more
doaj   +1 more source

NOTCH Signaling in Osteosarcoma

Current Issues in Molecular Biology, 2023
The combination of neoadjuvant chemotherapy and surgery has been promoted for the treatment of osteosarcoma; however, the local recurrence and lung metastasis rates remain high.
Zhenhao Zhang, Wei Wu, Zengwu Shao
doaj   +1 more source

Current perspectives of the signaling pathways directing neural crest induction. [PDF]

, 2012
The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I, Stuhlmiller, Timothy J   +1 more
core   +2 more sources

From the Notch Signaling Pathway to Ribosome Biogenesis [PDF]

Plant Signaling & Behavior, 2007
Nearly 240 WD repeat proteins have been identified from the Arabidopsis genome. Among these, some well characterized WDR proteins were shown to regulate various developmental processes in plants.1 We have recently isolated in Solanum chacoense a homolog of the Drosophila NOTCHLESS gene.
Sier-Ching, Chantha, Faiza, Tebbji, Daniel P, Matton   +2 more
openaire   +2 more sources

Cis-activation in the Notch signaling pathway [PDF]

, 2019
The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling.
Elowitz, Michael B., Nandagopal, Nagarajan, Santat, Leah A.   +2 more
core   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
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Involvement of the Notch signaling system in alveolar bone resorption

Japanese Dental Science Review, 2023
The Notch pathway is an evolutionarily preserved signaling pathway involved in a variety of vital cell functions. Additionally, it is one of the key regulators of inflammation, and controls the differentiation and function of different cells.
Aleksandar Jakovljevic, Nadja Nikolic, Lucrezia Paternò Holtzman, Pierre Tournier, Alexis Gaudin, Luca Cordaro, Iva Milinkovic   +6 more
doaj   +1 more source

Meningioma Transcript Profiles Reveal Deregulated Notch Signaling Pathway [PDF]

Cancer Research, 2005
Abstract Meningiomas constitute the second most common central nervous system tumor, and yet relatively little is known about the molecular events that are important for the pathogenesis and malignant progression of these tumors. We have used serial analysis of gene expression to compare the transcriptomes of nonneoplastic meninges and ...
Ileana C, Cuevas, Alison L, Slocum, Peter, Jun, Joseph F, Costello, Andrew W, Bollen, Gregory J, Riggins, Michael W, McDermott, Anita, Lal   +7 more
openaire   +2 more sources

Targeting self-renewal pathways in myeloid malignancies [PDF]

, 2013
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through ...
Copland, M., Sands, W.A., Wheadon, H.
core   +2 more sources