Results 41 to 50 of about 75,809 (268)

Fatigue assessment of semi-circular notched specimens produced by Laser Engineered Net Shaping method [PDF]

MATEC Web of Conferences, 2018
As a primary failure mechanism, fatigue failure of additively manufactured metallic parts has attracted considerable attention in both aerospace and biomedical applications.
Razavi Nima, Bordonaro Giancarlo, Ferro Paolo, Berto Filippo   +3 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Anderson Localization Phenomenon in One-dimensional Elastic Systems

, 2013
The phenomenon of Anderson localization of waves in elastic systems is studied. We analyze this phenomenon in two different set of systems: disordered linear chains of harmonic oscillators and disordered rods which oscillate with torsional waves.
Diaz-de-Anda, A., Flores, J., Gutierrez, L., Mendez-Sanchez, R. A., Monsivais, G., Morales, A.   +5 more
core   +1 more source

The Effect of Interchannel Time Difference on Localisation in Vertical Stereophony [PDF]

, 2015
Listening tests were conducted in order to analyse the localisation of band-limited stimuli in vertical stereophony. The test stimuli were seven octave bands of pink noise, with centre frequencies ranging from 125–8000Hz, as well as broadband pink noise.
Lee, Hyunkook, Wallis, Rory
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Investigating the impact of notch shapes on oxide–oxide ceramic matrix composites strength: A computational approach

International Journal of Ceramic Engineering & Science
This study utilizes finite element analysis (FEA) to explore the effect of standardized notch shapes—triangular, circular, and rectangular on the tensile behavior of oxide–oxide (O–O) ceramic matrix composites (CMCs) across various temperature ranges ...
Karthikeyan Ramachandran, Aayushi Soni, Doni Daniel Jayaseelan   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Experimental Study of Free-Convection from Rectangular Fins Array on a Heated Horizontal Plate with Notch Effects

مجلة النهرين للعلوم الهندسية, 2017
In this work , experimental investigation has been done for free-convection heat transfer from rectangular fins array on a heated horizontal base plate to surrounding air in the steady-state flow  condition  with  rectangular notch portion effects.
Saad Najeeb Shehab
doaj  

Linear Paul trap design for an optical clock with Coulomb crystals

, 2011
We report on the design of a segmented linear Paul trap for optical clock applications using trapped ion Coulomb crystals. For an optical clock with an improved short-term stability and a fractional frequency uncertainty of 10^-18, we propose 115In+ ions
A. Bjerhammar, A. Steane, C. Champenois, C. Zipkes, C.W. Chou, Ch. Monroe, Ch. Schwedes, D. Kielpinski, D. Meiser, D. Wineland, D.H.E. Dubin, D.J. Berkeland, D.J. Wineland, D.J. Wineland, E. Peik, E. Peik, F. Riehle, F.G. Major, G.D. Lin, H. Totsuji, H.C. Nägerl, I. Babuska, J. Keller, J. Millo, J.D. Prestage, J.E. Bernard, J.P. Schiffer, K. Pyka, K. Sugiyama, L. Deslauriers, L.S. Brown, M.J. Madsen, N. Herschbach, N.K. Pavlis, P. Schmidt, Q.A. Turchette, R.H. Dicke, R.J. Epstein, S. Schulz, T. E. Mehlstäubler, T. Legero, T. Liu, T. Rosenband, T. Rosenband, T. Rosenband, Th. Becker, W. Itano, W. Neuhauser   +47 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source