Results 101 to 110 of about 91,065 (316)
Genotoxicity Evaluation of The Novel Psychoactive Substance MTTA
International Journal of Molecular Sciences, 2023 MTTA, also known as mephtetramine, is a stimulant novel psychoactive substance characterized by a simil-cathinonic structure. To date, little has been studied on its pharmaco-toxicological profile, and its genotoxic potential has never been assessed. In order to fill this gap, the aim of the present work was to evaluate its genotoxicity on TK6 cells in
Monia Lenzi +4 more
openaire +3 more sources
Autism Research, EarlyView.ABSTRACT Autism Spectrum Disorder (ASD) is associated with altered interoception, empathy, self‐awareness, and alexithymia. However, limited research has been conducted to investigate the interrelationships of these constructs with psychopathological symptoms.
Antonio Kei‐Fung Shek +10 more
wiley +1 more source
New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. [PDF]
, 2019 Synthetic cannabinoids (SCs) were initially developed as pharmacological tools to probe the endocannabinoid system and as novel pharmacotherapies, but are now highly abused.
Diao, Xingxing, Huestis, Marilyn A.
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg +7 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Amoxicillin, a widely used β‐lactam antibiotic, requires improved pharmacokinetic characterization during breastfeeding. This study used a population pharmacokinetic (PopPK) approach to model amoxicillin concentrations in breast milk, identify variability sources and estimate infant exposure, applying worst‐case scenarios.
Sarah Baklouti +9 more
wiley +1 more source
Closing Evidence Gaps on the Prevalence and Harms of New Psychoactive Substances in Scotland [PDF]
, 2015 This paper considers the state of knowledge on New Psychoactive Substances (NPS) in Scotland, with a focus on prevalence and harms and puts forward proposals which may assist in closing existing evidence ...
Gillies, Allan
core
Neurochemical profiles of some novel psychoactive substances
European Journal of Pharmacology, 2013 Fourteen substances from the class of drugs sometimes known as “legal highs” were screened against a battery of human receptors in binding assays, and their potencies as inhibitors of monoamine uptake determined in functional in vitro assays. Thirteen of the test substances acted as inhibitors of monoamine uptake at submicromolar concentrations ...
Iversen, Les +5 more
openaire +4 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim The French authorities mandated the use of secure prescriptions for pregabalin on May 2021. This study aimed to evaluate the impact of this measure on pregabalin use and misuse in Nouvelle‐Aquitaine, a southwestern French region with around six million inhabitants.
Maika Munech‐Herran +5 more
wiley +1 more source
Mapping Current and Potential Sources of Routine Data Capture on New Psychoactive Substances in Scotland [PDF]
, 2015 The paper maps the data currently being captured on NPS, and provides a starting point for exploring the strengths and weaknesses of a number of existing data systems in Scotland, and opportunities for data ...
Gillies, Allan
core
Activity-based detection of consumption of synthetic cannabinoids in authentic urine samples using a stable cannabinoid reporter system [PDF]
, 2017 Synthetic cannabinoids (SCs) continue to be the largest group of new psychoactive substances (NPS) monitored by the European Monitoring Center of Drugs and Drugs of Abuse (EMCDDA).
Auwärter, Volker +3 more
core +1 more source