Results 111 to 120 of about 4,816,902 (277)

Editorial: Prescribing psychotropics: Misuse, abuse, dependence, withdrawal and addiction, Volume II

Frontiers in Psychiatry, 2022
Stefania Chiappini, Stefania Chiappini, Fabrizio Schifano, Giovanni Martinotti, Giovanni Martinotti   +4 more
doaj   +1 more source

Tolazoline, an alpha-adrenergic antagonist, may also block xylazine at off-target sites as inferred from molecular docking

Frontiers in Chemical Biology
Xylazine, a non-opioid α2-adrenoceptor agonist, is increasingly implicated in misuse and opioid-adulterated overdoses. Tolazoline, a non-selective α-adrenergic antagonist, is widely used in veterinary medicine to reverse xylazine-induced sedation and ...
Giuseppe Floresta, Giuseppe Floresta, Vincenzo Patamia, Alberto Granzotto, Alberto Granzotto, Davide Arillotta, Davide Arillotta, Gabriele Duccio Papanti, Gabriele Duccio Papanti, Amira Guirguis, John M. Corkery, Giovanni Martinotti, Giovanni Martinotti, Stefano L. Sensi, Stefano L. Sensi, Stefano L. Sensi, Stefano L. Sensi, Fabrizio Schifano   +17 more
doaj   +1 more source

Assessment and management of dyspareunia in peri‐ and postmenopausal women: A phenotype‐based gynecologic approach

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Dyspareunia in peri‐ and postmenopausal women is common, clinically consequential, and often undertreated in gynecologic practice. Although genitourinary syndrome of menopause (GSM) is a frequent contributor, intercourse‐related pain may also reflect vestibular, pelvic floor, dermatologic, inflammatory, treatment‐related, and psychosocial ...
Marek Broul, Marcel Vančo, Jaroslava Banýrová, Aneta Hujová   +3 more
wiley   +1 more source

Editorial: Prescribing Psychotropics: Misuse, Abuse, Dependence, Withdrawal and Addiction

Frontiers in Psychiatry, 2021
Stefania Chiappini, Stefania Chiappini, Fabrizio Schifano, Giovanni Martinotti, Giovanni Martinotti   +4 more
doaj   +1 more source

Rapid and simple LC-MS/MS-Screening of 64 novel psychoactive substances using dried blood spots

, 2014
The range of novel psychoactive substances (NPS) including phenethylamines, cathinones, piperazines, tryptamines, etc. is continuously growing. Therefore, fast and reliable screening methods for these compounds are essential and needed.
König, Stefan, Weinmann, Wolfgang, Lars Ambach, Stefan König, Ambach, Lars, Hernandez, Ana, Wolfgang Weinmann, Ana Hernández Redondo   +7 more
core   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Deep Learning-Enabled MS/MS Spectrum Prediction Facilitates Automated Identification Of Novel Psychoactive Substances. [PDF]

Anal Chem, 2023
Wang F, Pasin D, Skinnider MA, Liigand J, Kleis JN, Brown D, Oler E, Sajed T, Gautam V, Harrison S, Greiner R, Foster LJ, Dalsgaard PW, Wishart DS.   +13 more
europepmc   +1 more source

Psychopharmacology of Methamphetamine in Relation to the United Kingdom Sentencing Guidance: Comparative Analysis with Amphetamine, Cocaine and Heroin

Brain Sciences
Methamphetamine presents a significant scientific and legal challenge for sentencing because, although it is a Class A drug in England and Wales, it is not assigned explicit indicative quantity thresholds within the principal Sentencing Council guideline.
Amira Guirguis, Arianna Giorgetti, Jegak Seo, John Martin Corkery, Fabrizio Schifano   +4 more
doaj   +1 more source

Safety Assessment and Hypoglycemic Effect of Moringa oleifera Lam. Seed Lectin (WSMoL) in Alloxan‐Induced Diabetic Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos, Matheus Cavalcanti de Barros, Cleidiane Silva Vieira de Souza, Ryan Cristian da Silva, Luana Cassandra Breitenbach Barroso Coelho, Maria Tereza dos Santos Correia, Fernanda das Chagas Ângelo Mendes Tenório, Alisson Macário de Oliveira, Thiago Henrique Napoleão, Robson Raion de Vasconcelos Alves, Patrícia Maria Guedes Paiva   +10 more
wiley   +1 more source

The evaluation of dual laser handheld raman spectroscopy for identifying novel psychoactive substances [PDF]

Novel psychoactive substances have been increasing over the last decade with more than 450 derivatives available on the market. The issue with novel psychoactive substances is much more complicated than their effects/side effects. Hence, these substances
Assi, S, Osselton, D, Wallis, B
core   +3 more sources