Results 161 to 170 of about 4,731 (194)
A SNP of NPC1L1 Affects Cholesterol Absorption in Japanese
Journal of Atherosclerosis and Thrombosis, 2010 Ezetimibe is known to target Niemann-Pick Type C1 Like1 (NPC1L1), a key protein in intestinal cholesterol absorption, and thus to decrease serum LDL-cholesterol (LDL-C) levels. The response of serum LDL-C levels to ezetimibe was reported to differe among NPC1L1 haplotypes.We analyzed NPC1L1 genotypes in Japanese and investigated differences in markers ...
Akira Honda +2 more
exaly +5 more sources
Cell Metabolism, 2008 SummaryNiemann-Pick C1-like 1 (NPC1L1) is a polytopic transmembrane protein that plays a critical role in cholesterol absorption. Ezetimibe, a hypocholesterolemic drug, has been reported to bind NPC1L1 and block cholesterol absorption.
Bao-Liang Song, Bo-Liang Li, Liang Ge
exaly +2 more sources
Journal of Agricultural and Food Chemistry, 2019 Xanthohumol (Xan) is a prenylated chalcone mainly found in hops; it has been demonstrated to function against hypercholesterolemia, hyperlipidemia, and atherosclerosis.
Min-Hsiung Pan +2 more
exaly +2 more sources
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Human NPC1L1 Expression is Positively Regulated by PPARα
Pharmaceutical Research, 2010Niemann-Pick C1-like 1 (NPC1L1), a pharmacological target of ezetimibe, is responsible for cholesterol absorption in enterocytes and hepatocytes. In the present study, the involvement of peroxisome proliferator-activated receptor α (PPARα) and its cofactor, PPARγ coactivator 1α (PGC1α) in the transcriptional regulation of human NPC1L1 was analyzed ...
Yuki, Iwayanagi +6 more
openaire +2 more sources
Sequencing of a npc1L1 mutation in larval zebrafish
Proceedings of the West Virginia Academy of Science, 2020NPC1L1 transport protein is located in the lumen of the intestines and is critical for cholesterol absorption. The reason why we study NPC1L1 is because cholesterol absorption in the intestines affect obesity and diabetes which is still under investigation.
Jordan Marcelle Smith +2 more
openaire +1 more source
Inactivating Mutations in NPC1L1 and Protection From Coronary Heart Disease [PDF]
New England Journal of Medicine, 2014 Background—Ezetimibe lowers plasma levels of low-density lipoprotein (LDL) cholesterol by inhibiting the activity of the Niemann–Pick C1-like 1 (NPC1L1) protein.
Rosanna Asselta +2 more
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Dissecting NPC1L1-mediated cholesterol absorption
Future Lipidology, 2008Wei Qi & Bao-Liang Song† †Author for correspondence Chinese Academy of Sciences, The State Key Laboratory of Molecular Biology, Institute of Biochemistry & Cell Biology, Shanghai Institutes for Biological Sciences, China Tel.: +86 215 492 1649; Fax: +86 215 492 1649; blsong@sibs.ac.cn ‘...NPC1L1 is critical for dietary cholesterol absorption and is ...
Wei Qi, Bao-Liang Song
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Sequencing of an npc1L1 mutation in larval zebrafish.
Proceedings of the West Virginia Academy of Science, 2019How the intestinal absorption of lipids impact dyslipidemias such as obesity and diabetes is currently under debate. NPC1L1 is a critical transport protein in enterocyte cholesterol absorption. To understand the mechanism of intestinal NPC1L1 uptake within the enterocyte, we are creating a npc1l1 -/- (knockout) line in zebrafish.
James William Walters, Jordan Smith
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Emodin lows NPC1L1-mediated cholesterol absorption as an uncompetitive inhibitor
Bioorganic & Medicinal Chemistry Letters, 2022Emodin (EM) is one of the active components of the traditional Chinese medicine rhubarb, and there is evidence of its hypolipidemic activity, though the exact mechanism is unknown. NPC1L1 is a key protein in human cholesterol uptake that is primarily expressed in hepatocytes and gastrointestinal epithelial cells.
Jingsen, Meng +8 more
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HNF4α is a Crucial Modulator of the Cholesterol-Dependent Regulation of NPC1L1
Pharmaceutical Research, 2007Niemann-Pick C1-like 1 (NPC1L1) has been identified as a target of ezetimibe and found to be responsible for intestinal cholesterol absorption. Although, it was recently demonstrated that sterol responsive element binding protein 2 (SREBP2) is responsible for the cholesterol-dependent down-regulation of NPC1L1, the molecular mechanism of NPC1L1 ...
Yuki, Iwayanagi +2 more
openaire +2 more sources