Results 171 to 180 of about 4,731 (194)
Some of the next articles are maybe not open access.
Molecular Pharmacology, 2007
Ezetimibe is the first in class 2-azetidinone that decreases plasma cholesterol by blocking intestinal cholesterol absorption. Ezetimibe effectively reduces plasma cholesterol in several species including human, monkey, dog, hamster, rat, and mouse, but the potency ranges widely.
Brian E, Hawes +6 more
openaire +2 more sources
Ezetimibe is the first in class 2-azetidinone that decreases plasma cholesterol by blocking intestinal cholesterol absorption. Ezetimibe effectively reduces plasma cholesterol in several species including human, monkey, dog, hamster, rat, and mouse, but the potency ranges widely.
Brian E, Hawes +6 more
openaire +2 more sources
Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand
Bioorganic & Medicinal Chemistry Letters, 2009During our effort to design a receptor binding assay to aid in the elucidation of the molecular mechanism of ezetimibe, we prepared a sulfur-35 containing radioligand which exhibits improved potency over the glucuronide conjugate of ezetimibe in both native enterocyte brush border membranes and membranes from cells expressing recombinant NPC1L1. Herein,
Joseph P, Simeone +8 more
openaire +2 more sources
VARIATION IN HMGCR AND NPC1L1 AND INFLAMMATORY BIOMARKERS
Journal of the American College of Cardiology, 2022Jiawen Li +7 more
openaire +1 more source
Niemann–Pick C1 Like 1 (NPC1L1) an Intestinal Sterol Transporter
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2009Harry R Davis, Scott W Altmann
exaly
HNF4α Is a Crucial Modulator of the Cholesterol-Dependent Regulation of NPC1L1
Pharmaceutical Research, 2008Tappei Takada
exaly