Results 101 to 110 of about 33,925 (257)

Neurohumoral Biomarker Profile Associated With Blood Pressure Response After Renal Denervation. [PDF]

J Clin Hypertens (Greenwich)
ABSTRACT Blood pressure (BP) response after renal denervation (RDN) remains heterogeneous. This study explored whether baseline neurohumoral and inflammation‐related biomarkers were associated with a pronounced ambulatory BP response after RDN. This single‐center post hoc analysis included 40 patients with uncontrolled essential hypertension who ...
Liang W, Wang Y, Ai L, Sun R, Zhao X, Yu H, Zhang X, Li C, Chen J, Ma R, Wang Q, Zhang X, Yu J.   +12 more
europepmc   +2 more sources

The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review. [PDF]

Hippocampus
ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
Till MAC, Reid HMO, Murphy I, Christie BR.   +3 more
europepmc   +2 more sources

Investigação dos efeitos neuroprotetores da grelina e do neuropeptídeo Y em um modelo experimental da doença de Alzheimer [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2012.O acúmulo da proteína beta amilóide (AB) no sistema nervoso central (SNC) e os prejuízos cognitivos ...
Santos, Vanessa Valgas dos
core  

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model

Indian Journal of Endocrinology and Metabolism, 2012
Neuropeptide Y (NPY) is a neuropeptide widely expressed in the brain and a peptide transmitter of sympathetic nervous system (SNS) co-released with noradrenaline (NA) in prolonged stress.
Suvi T Ruohonen, Ullamari Pesonen, Eriika Savontaus   +2 more
doaj   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

MicroRNA-124–3p regulates NPY to affect appetite in individuals with depressive disorder

Brain, Behavior, & Immunity - Health
While the pathogenesis of depression has been extensively studied, the mechanisms underlying appetite suppression in depression remain poorly understood. This study aimed to elucidate the role of the microRNA-124–3p (miR-124–3p)/neuropeptide Y (NPY) axis
Qianfa Yuan, Chunshui Yu, Jing Lu, Lingxiao Fang, Leiyu Kuang, Zhizhong Xu, Chunyan Wen, WeiChao Su, Yan Qiu, Zhiyuan Huang, Xianhua Zhang, Jue He   +11 more
doaj   +1 more source

pH sensitivity of NPY-RFPs.

, 2015
To assess the pH sensitivity of FPs within intact granules, cells were transfected with NPY-FPs and exposed to 10 mM NH4Cl to neutralize the luminal pH. A Examples images of cells expressing NPY-mEGFP or NPY-mCherry.
Kim Vestö (757604), Maria Helou (757605), Nikhil R. Gandasi (757603), Jan Saras (757606), Sebastian Barg (367440), Peng Yin (46588)   +5 more
core   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source