Results 71 to 80 of about 47,863 (285)
Advanced Science, EarlyView.PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang +14 more
wiley +1 more source
GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
PLoS Biology, 2023 It is well known that the neuropeptide Y (NPY)/agouti-related peptide (AgRP) neurons increase appetite and decrease thermogenesis. Previous studies demonstrated that optogenetic and/or chemogenetic manipulations of NPY/AgRP neuronal activity alter food ...
Youjin Oh +7 more
doaj +1 more source
Mechanisms by which the orexigen NPY regulates anorexigenic α-MSH and TRH.
American Journal of Physiology. Endocrinology and Metabolism, 2013 Protein posttranslational processing is a cellular mechanism fundamental to the generation of bioactive peptides, including the anorectic α-melanocyte-stimulating hormone (α-MSH) and thyrotropin-releasing hormone (TRH) peptides produced in the ...
Nicole E. Cyr +7 more
semanticscholar +1 more source
TUNTUTAN HUKUM ORANG TUA BALITA RAN TERHADAP BABYSITTER DI PENITIPAN BAYI BDHP JAKARTA YANG TELAH MELAKUKAN PENGANIAYAAN TERHADAP RAN [PDF]
, 2016 Penganiayaan yang dilakukan oleh Babysitter DS di BDHP Jakarta, terhadap balita RAN, Umur 14 Bulan, berakibat korban kekerasan oleh pengasuhnya tersebut luka-luka, pada hari Jumat 29 Agustus 2014, RAN diduga dianiaya oleh pengasuhnya di penitipan bayi
ROBET FRANSCISCO, NPY : 111000364
core
Advanced Science, EarlyView.Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun +14 more
wiley +1 more source
Molecular Metabolism, 2023 Objective: One of leptin's main targets in the hypothalamus are neuropeptide Y (NPY) neurons, with selective deletion of leptin receptors (Lepr) specifically in Npy neurons resulting in major alterations of energy partitioning between fat and bone mass ...
Nicola J. Lee +5 more
doaj
Endocrinology, 2012 Hypothalamic neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons act to sense and coordinate the brain's responses to metabolic cues. One neuronal network that is very sensitive to metabolic status is that controlling fertility. In this study, we
J. Roa, A. Herbison
semanticscholar +1 more source
NPY and the Regulation of Behavioral Development [PDF]
Neuron, 2003 Neuropeptide Y is implicated in the regulation of feeding in vertebrates, but recent studies in transgenic mice are contradictory. In this issue of Neuron, Wu et al. show a dual role for the Drosophila NPY (dNPF) in the developmental regulation of larval foraging and social behaviors, demonstrating a conserved role for this peptide in complex behaviors.
openaire +3 more sources
Neutron Stars with Bose-Einstein Condensation of Antikaons as MIT Bags
, 2010 We investigate the properties of an antikaon in medium, regarding itas a MIT bag. We first construct the MIT bag model for a kaon with$\sigma^*$ and $\phi$ in order to describe the interaction of$s$-quarks in hyperonic matter in the framework of the ...
Hong, S. W., Hyun, C. H., Ryu, C. Y.
core +1 more source
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice [PDF]
, 2018 We thank AstraZeneca for providing AZ-4217, Mark Smith (Imperial College, London) and Yuchio Yanagawa (Gunma University, Maebashi) for VGlut2-GFP and GAD67-GFP tissue, respectively.
Allsop, David J. P. +15 more
core +5 more sources