Results 101 to 110 of about 33,318 (195)

Agrimoniin Alleviates Ferroptosis in Cold‐Stored DCD Liver Grafts Through Activation of the Nrf‐2 Pathway

Cell Proliferation, EarlyView.
Supplementing the liver preservation solution with agrimoniin protects donation after cardiac death (DCD) grafts by activating the Nrf‐2 pathway. This reduces ferroptosis, oxidative stress, and inflammation during cold storage, significantly improving graft viability.
Enqiang Chang, Xiaoting Liao, Guanghua Tao, Bijun Luo, Sheng He, Linghui Pan   +5 more
wiley   +1 more source

Chronic Stress Enhances Hepatotoxic Effects of Sorbic and Benzoic Acids in a Rat Model [PDF]

Journal of Stress Physiology & Biochemistry
Background: The individual effects of psychological stress and food preservatives on the liver—the body’s primary detoxification organ—are well-documented; however, little is known about their combined impact.
D.O. Karimov, Yu.V. Ryabova, E.F. Repina, Ya.V. Valova, A.A. Gizatullina, T.G. Yakupova, D. A. Smolyankin, O.A. Khmel, M.V. Kurilov   +8 more
doaj  

Modest induction of phase 2 enzyme activity in the F-344 rat prostate [PDF]

, 2006
Background Prostate cancer is the most commonly diagnosed malignancy in men and is thought to arise as a result of endogenous oxidative stress in the face of compromised carcinogen defenses. We tested whether carcinogen defense (phase 2) enzymes could be
Sunita B Jones, James D Brooks, A Jemal, WG Nelson, WH Lee, X Lin, JD Brooks, M Nakayama, S Tsuchida, LW Wattenberg, TW Kensler, HJ Prochaska, SR Spencer, P Talalay, Y Zhang, DJ Meyer, H Raza, EM van Lieshout, MJ De Long, JD Brooks, JD Brooks, MT Huang, WH Habig, HJ Prochaska, MM Bradford, T Shirai, TW Kensler, NV Matusheski, F Kassie, JH Cohen, LN Kolonel, TW Kensler, A Camoirano, LK Dennis, MO Ripple, MO Ripple, MO Ripple, DC Malins, DC Malins, DC Malins, J Carpten, J Xu, A Zhou, LC Clark, OP Heinonen, E Giovannucci, CJ Henderson, F de Braud, DS Michaud, L Ye, R Munday, T Primiano   +51 more
core   +2 more sources

Integrated miRNA–mRNA Analysis Reveals Obesity‐Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Obesity is characterised by pathological alterations in visceral white adipose tissue (vWAT) that may contribute to the development of type 2 diabetes (T2D). While microRNAs (miRNAs) are key post‐transcriptional regulators, comprehensive human vWAT profiling across metabolic states remains limited.
Elsa Villa‐Fernández, Ana Victoria García, Laura Gallardo‐Nuell, Miguel García‐Villarino, Judit Fernández‐García, Aldara Martin Alonso, Claudia Lozano‐Aida, Lorena Suárez Gutiérrez, Pedro Pujante, Jessica Ares, Tomás González‐Vidal, Raquel Rodríguez Uría, Sandra Sanz Navarro, María Moreno Gijón, Lourdes María Sanz Álvarez, Estrella Olga Turienzo Santos, José Manuel Fernández‐Real, Mario Fernández Fraga, Elías Delgado, Carmen Lambert   +19 more
wiley   +1 more source

NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma

Cell Communication and Signaling, 2019
Background Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell.
Hong-Zhong Zhou, Han-Qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Bo Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang, Juan Chen   +10 more
doaj   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives [PDF]

, 2016
The Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response elements pathway enables cells to survive oxidative stress conditions through regulating the expression of cytoprotective enzymes such
Alsaid, Mansour S, Arafa, Reem K, Dinkova-Kostova, Albena T, Elghazawy, Nehal H, Ghorab, Mostafa M, Higgins, Maureen, Shahat, Abdelaaty A   +6 more
core   +3 more sources

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation [PDF]

, 2012
Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on exposure to high glucose concentrations, inflammation, cell aging and senescence.
Anwar, M. Maqsud, Imbasi, Precious, Kitteringham, Neil, Momiji, Hiroshi, Moriguchi, Takashi, Park, B. Kevin, Rabbani, Naila, Souma, Tomokazu, Thornalley, Paul J., Xue, Mingzhan, Yamamoto, Masayuki   +10 more
core   +1 more source