Results 91 to 100 of about 33,318 (195)

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Lung Circulation Modeling: Status and Prospect [PDF]

, 2006
Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are ...
Audi, Said H., Clough, Anne V., Krenz, Gary S., Molthen, Robert C.   +3 more
core   +1 more source

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration [PDF]

, 2013
Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism.
Adam Q. Bauer, Benoit I. Giasson, David F. Wozniak, David M. Holtzman, David R. Weaver, Erik D. Herzog, Erik S. Musiek, Garret A. FitzGerald, Guangrui Yang, Jee Hoon Roh, Jilg, John B. Hogenesch, Joseph P. Culver, Joshua T. Dearborn, Kondratov, Kondratova, Kondratova, Krikor Dikranian, Laposky, Laura Qi, Miranda M. Lim, Reppert, Valnegri, Xilma Ortiz-Gonzalez, Yool Lee, Yu   +25 more
core   +2 more sources

Early Dapagliflozin and Melatonin Treatment Ameliorated LV Fibrosis via Suppressing TGF‐β1/Smads and Activating Nrf2‐ARE Signaling in MI Rodent

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study tested whether combined dapagliflozin (DAPA) and melatonin (Mel) therapy was superior to merely one for ameliorating the left ventricular (LV) fibrosis/remodeling and improving LV ejection fraction (LVEF) in rats after acute myocardial infarction (AMI). In vitro study demonstrated that DAPA treatment significantly suppressed the TGF‐
Jiunn‐Jye Sheu, Jui‐Ning Yeh, Han‐Tan Chai, John Y. Chiang, Chi‐Ruei Huang, Jun Guo, Hon‐Kan Yip   +6 more
wiley   +1 more source

Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival [PDF]

, 2014
BACKGROUND: The transcription factor Nrf2 is a key regulator of the cellular antioxidant response, and its activation by chemoprotective agents has been proposed as a potential strategy to prevent cancer. However, activating mutations in the Nrf2 pathway
Boshoff, C, Flanagan, JM, Funes, JM, Henderson, S, Kaufman, R, Moncada, S, Pedley, B, Robson, M   +7 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Efficacy, pharmacokinetic and pharmacodynamic evaluation of Apaziquone in the treatment of non- muscle invasive bladder cancer [PDF]

, 2017
Introduction: Apaziquone (also known as EO9 and Qapzola) is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1) and has the ability to kill aerobic and/or hypoxic cancer cells.
Comer E, G. J. Peters, G. Reddy, Guancial EA, H. R. Hendriks, J. B. Sweeney, Kal HB, Lamm DL, Panach-Navarrete J, Phillips RM, R. M. Phillips, Walton MI, Workman P   +12 more
core   +2 more sources

Curcumin Alleviates the Osteogenesis Inhibition and the Aging Process in BMSCs Induced by Iron Overload Through Activating the NRF2/GPX4 Pathway

Phytotherapy Research, EarlyView.
Under iron overload conditions, curcumin inhibits cellular senescence and promotes osteogenic differentiation by activating the NRF2/GPX4 signaling pathway in bone marrow mesenchymal stem cells (BMSCs), thereby preventing the onset of osteoporosis. ABSTRACT Dysregulated proliferation and differentiation of bone marrow mesenchymal stem cells (BMSCs ...
Jingmin Che, Qing Feng, Zhixia Zhao, Jingying Sun, Weihao Ren, Yangmeng Feng, Cuixiang Xu, Xu‐Hui Li   +7 more
wiley   +1 more source

Paternal Malnutrition has Organ-Specific Intergenerational Effects on Mitochondrial Function and Oxidative Stress Induced DNA Damage in Male Mouse Offspring. [PDF]

Mol Nutr Food Res
Preconceptional paternal exposure to a low protein diet influenced background levels of mitochondrial function, expression of antioxidant genes and oxidative stress induced DNA damage in a tissue‐specific manner in offspring. Paternal lifestyle might therefore explain part of the inter‐individual variation.
Lenssen ES, de Assis S, Remels A, Santana da Cruz R, van Schooten FJ, Godschalk RWL.   +5 more
europepmc   +2 more sources

NAD(P)H:Quinone oxidoreductase 1 inducer activity of novel 4-aminoquinazoline derivatives [PDF]

, 2016
Fourteen novel 4-aminoquinazoline derivatives 2-15 were designed and synthesized. The structure of the newly synthesized compounds was established on the basis of elemental analyses, IR, (1)H-NMR, (13)C-NMR, and mass spectral data.
Abdelaaty A. Shahat, Albena T. Dinkova-Kostova, AlSaid MS, Chandra T, Kiruthiga B, Mansour S. Alsaid, Marwa G. El-Gazzar, Maureen Higgins, Meyyanathan SN, Mostafa M. Ghorab, Pandya T, Rani P   +11 more
core   +2 more sources