Results 111 to 120 of about 33,318 (195)

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients [PDF]

, 2017
The activity of the transcription factor nuclear factor-erythroid 2 p45-derived factor 2 (NRF2) is orchestrated and amplified through enhanced transcription of antioxidant and antiinflammatory target genes.
Adelaide R. Tousley, Albena T. Dinkova-Kostova, Aleksey G. Kazantsev, Alexei Degterev, Andrew Snyder, Bertrand, Blair R. Leavitt, Cho Low, Clemens Steegborn, Colúm Connolly, David Llères, Donald C. Lo, Ellen Sapp, Eranthie Weerapana, James R. C. Miller, Kimberly Kegel-Gleason, Kobayashi, Leslie M. Thompson, Linda S. Kaltenbach, Lisa A. Crawford, Lisa M. Ellerby, Lisa Meisel, Luisa Quinti, Marian DiFiglia, Matthew Fuszard, Maureen Higgins, Michael A. Schwarzschild, Michael J. Van Kanegan, Möller, Ningzhe Zhang, Petr Vodicka, Phani, Quinti, Ross Stein, Ruth E. Farmer, Sarah J. Tabrizi, Sharadha Dayalan Naidu, Sorolla, Steven M. Hersch, Susanta Samajdar, Sébastien Moniot, Ujjainwalla, Ulrike Träger, Vanita Chopra, Vijay Potluri, Xiqun Chen   +45 more
core   +4 more sources

Bibliometric Analysis of Cubebenes and Related Sesquiterpenes: Natural Occurrence, Biosynthesis, Pharmacological Activities, and In‐Silico‐Based Future Therapeutic Potential

eFood, Volume 7, Issue 3, June 2026.
Cubebene‐related sesquiterpenes, found across diverse biological sources, exhibit promising pharmacological activities, including anti‐inflammatory, neuroprotective, and anticancer effects. This review highlights their molecular diversity, ADME profiles, and predicted multitarget interactions, underscoring their therapeutic relevance and potential in ...
Khadija Boualam, Ahmet B. Ortaakarsu, Sohaib Khatib, Mohamed A. Farag, Mansour Sobeh   +4 more
wiley   +1 more source

Equol Alleviates Postmenopausal Metabolic Dysfunction‐Associated Steatotic Liver Disease via the GPR30/PI3K Pathway

eFood, Volume 7, Issue 3, June 2026.
This study demonstrates that equol exerts a protective effect on metabolic dysfunction‐associated steatotic liver disease in both in vivo and in vitro by activating the GPR30/PI3K/Nrf2 signaling pathway. Equol's interaction with GPR30 and its ability to activate the PI3K/Nrf2 pathway provide a promising therapeutic strategy for treating metabolic ...
Hanqiang Cui, Bin Wang, Bo Zou, Guiming Zhang, Zhe Xu, Shuo Li, Jing Xu, Xiangmin Ni, Jian Wang   +8 more
wiley   +1 more source

β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers

Scientific Reports, 2017
NQO1 is a FAD-binding protein that can form homodimers and reduce quinones to hydroquinones, and a growing body of evidence currently suggests that NQO1 is dramatically elevated in solid cancers.
Yang Yang, Xianchun Zhou, Ming Xu, Junjie Piao, Yuan Zhang, Zhenhua Lin, Liyan Chen   +6 more
doaj   +1 more source

Nuclear Factor E2–Related Factor 2–Mediated Induction of NAD(P)H:Quinone Oxidoreductase 1 by 3,5-Dimethoxy-trans-stilbene

Journal of Pharmacological Sciences, 2011
.: NAD(P)H:quinone oxidoreductase 1 (NQO1), a phase II enzyme, plays an important role in the detoxification or chemoprotection of carcinogens, and induction of this enzyme is a target for the prevention of carcinogenesis.
Eun-Jung Park, Hye-Young Min, Hyen Joo Park, Hwa-Jin Chung, Yong-Hyun Ahn, Jae-Ho Pyee, Sang Kook Lee   +6 more
doaj   +1 more source

Postbiotic Supernatants From Psychobiotic Strains Modulate Antioxidant and Serotonergic Responses

eFood, Volume 7, Issue 3, June 2026.
Cell‐free postbiotic supernatants obtained from psychobiotic strains exhibit strain‐dependent antioxidant and serotonergic effects. SCFA‐rich metabolites enhance antioxidant protection and modulate serotonin release in enterochromaffin cells, supporting their potential as functional ingredients for gut and brain health.
Cocean Ana‐Maria, Zorita Diaconeasa, Calina Ciont, Razvan Odocheanu, Alexandra Machitescu, Floricuta Ranga, Dan Cristian Vodnar   +6 more
wiley   +1 more source

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Fungal Polysaccharides as Next‐Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs.
Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian   +6 more
wiley   +1 more source

miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis

Cancer Cell International
Background Cancer cells undergo a metabolic shift termed the Warburg effect, transitioning from oxidative phosphorylation to aerobic glycolysis and promoting rapid tumor proliferation. Quinone oxidoreductase (NQO1), a cytosolic flavoprotein, is important
Yixuan Wang, Houkun Zhou, Ying Liu, Xingyu Zhao, Shuhao Wang, Zhenhua Lin   +5 more
doaj   +1 more source