Results 71 to 80 of about 33,318 (195)

Angelica keiskei, an emerging medicinal herb with various bioactive constituents and biological activities. [PDF]

, 2017
Angelica keiskei (Miq.) Koidz. (Umbelliferae) has traditionally been used to treat dysuria, dyschezia, and dysgalactia as well as to restore vitality. Recently, the aerial parts of A. keiskei have been consumed as a health food.
Jafari, Mahtab, Kil, Yun-Seo, Pham, Sally T, Seo, Eun Kyoung   +3 more
core   +1 more source

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, EarlyView.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Suppression of NAD(P)H-quinone oxidoreductase 1 enhanced the susceptibility of cholangiocarcinoma cells to chemotherapeutic agents [PDF]

, 2009
La lateralidad de la jugadora con el rol de base puede ser sólo una característica individual, o bien un factor influyente en el juego de su equipo, y por tanto, una herramienta a considerar por parte del equipo rival.
Ponsilp Zeekpudsa, Veerapol Kukongviriyapan, Laddawan Senggunprai, Banchob Sripa, Auemduan Prawan   +4 more
core   +4 more sources

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Cellular and molecular mechanisms of alpha lipoic acid’s protective effects against diclofenac-induced hepatorenal toxicity

Journal of Veterinary Research
The cellular and molecular pathways of α-lipoic acid’s (ALA’s) protective effect were assessed against diclofenac (DIC) hepatorenal injury in vivo and against a pro-inflammatory stimulus in vitro.
Ogaly Hanan A., Hassan Neven, Elsalam Reham M. Abd, Badawy Shymaa El, Alsherbiny Muhammad A., Hassan Bardes, Al-Zahrania Fatimah A.M., Othman Gehan, Li Chun Guang, Elmosalamy Sherif H.   +9 more
doaj   +1 more source

Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population [PDF]

, 2012
BACKGROUND: Oxidative stress related genes modify the effects of ambient air pollution or tobacco smoking on lung function decline. The impact of interactions might be substantial, but previous studies mostly focused on main effects of single genes ...
A Comandini, Ashish Kumar, BL Fridley, BW Martin, C Nickel, CF Tseng, Christian Schindler, Consortium International HapMap, D Karolchik, D Thomas, DB Hancock, Dirkje S. Postma, DJ Slebos, E Bouzigon, E Repapi, EK Silverman, Erich W. Russi, F Kauffmann, Florence Demenais, Florian Kronenberg, H van der Vaart, Harish Phuleria, HJ Schünemann, HL Johnsen, HP Kim, I Curjuric, I Rahman, IA Yang, IP Hall, Ivan Curjuric, J Smolonska, J Sunyer, JA Araujo, JB Wilk, JD Sacks, JQ He, K Aoshiba, K Stavem, K Yu, L Le Marchand, LJ Liu, M Ashburner, M Kaimul Ahsan, M Siedlinski, M Tomita, Margot Haun, Marie-Pierre Dubé, MD Eisner, Me Obeidat, Medea Imboden, MF Moffatt, MH Cho, MJ Ege, MS Artigas, N Kunzli, N Kunzli, N Li, N Li, NA Elliott, Nicole M. Probst-Hensch, Nino Künzli, P Carta, P Kraft, P Lange, PG Burney, Rachel Nadif, SG Pillai, SG Pillai, SH Downs, SP Faux, Thierry Rochat, U Ackermann-Liebrich, W Gauderman, W MacNee, Y Aulchenko, Y Li, YM Van Durme   +76 more
core   +7 more sources

Preparation, Component Identification, and Antioxidant Activity of Anthocyanins From Punica granatum “Tunisia”

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang, Xu‐han Yang, Meng‐qi Zhang, Xu Guo, Ning‐yang Li, Fang‐yu Long, Chao Liu   +6 more
wiley   +1 more source

Functions of NQO1 in Cellular Protection and CoQ10 Metabolism and its Potential Role as a Redox Sensitive Molecular Switch

Frontiers in Physiology, 2017
NQO1 is one of the two major quinone reductases in mammalian systems. It is highly inducible and plays multiple roles in cellular adaptation to stress.
David Ross, David Siegel
doaj   +1 more source

Expression of NAD(P)H quinone dehydrogenase 1 (NQO1) is increased in the endometrium of women with endometrial cancer and women with Polycystic Ovary Syndrome [PDF]

, 2017
OBJECTIVE: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). AIM: To investigate whether the endometrium of women with PCOS possess gene expression changes similar to those found in EC ...
Asher, Barry, Bey, Chatr-Aryamontri, Crosbie, Crosbie, Cui, Fagerholm, Fearnley, Galazis, Haoula, Hevir, Hickey, Husing, Iskander, Jamshidi, Jansen, Kandoth, Lajin, Li, Martin, Montano, Montojo, Morrissy, Peigne, Phillips, Piltonen, Robinson, Ross, Schindler, Schmandt, Scott, Shafiee, Shafiee, Shafiee, Shafiee, Shang, Siegel, Siegel, Talalay, Trapnell, Wild, Williams-Brown, Yildiz, Zorn   +44 more
core   +4 more sources

Myo‐Inositol Mitigates Oxidative Stress in Bovine Mammary Epithelial Cells via Activation of the SIRT5/Nrf2 Signaling Axis

Animal Research and One Health, EarlyView.
Myo‐inositol alleviates oxidative stress in dairy cow mammary epithelial cells via the Sirt5/Nrf2 pathway to promote mitochondrial fusion. This graphical abstract was created with BioRender.com. ABSTRACT High‐yielding dairy cows are susceptible to mammary gland oxidative stress due to prolonged intensive lactation, leading to redox imbalance.
Yufei Zhang, Yu Cao, Meng Zhang, Huijie Hu, He Ma, Junlong Bi, Juxiong Liu, Shoupeng Fu, Wenjin Guo   +8 more
wiley   +1 more source