Results 11 to 20 of about 33,318 (195)

The Effect of high-intensity interval training with coenzyme Q10 supplementation on the Nrf2 and NQO1 in soleus muscle of older rats [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2023
Background and Purpose: Increased oxidative stress is the main characteristic of all types of age-related injuries. Based on the role of physical activity in adaptive responses to oxidative stress and importance of nutritional supplements, the aim of ...
Zahra Noruzi, Javad Nemati, Mohsen Salesi, Rasoul Rezai, Mohammad Hemmatinafar   +4 more
doaj   +1 more source

Association between ТР53, MDM2 and NQO1 gene polymorphisms and viral load among women with human papillomavirus

Вавиловский журнал генетики и селекции, 2022
The risk of cervical cancer is caused by persistent human papillomavirus (HPV) infection. Cervical cancer is the most frequent cancer among women. Our purpose was to investigate the association between TP53 215C>G (Pro72Arg), MDM2 -410T>G, and NQO1
A.H. AlBosale, E. V. Mashkina
doaj   +1 more source

Serpin family A member 1 is an oncogene in glioma and its translation is enhanced by NAD(P)H quinone dehydrogenase 1 through RNA-binding activity

Open Medicine, 2022
Serpin family A member 1 (SERPINA1) is expressed abundantly in gliomas and can predict unfavorable prognosis of patients with glioma. Studies have shown that nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 (NQO1) can promote the ...
Liu Wenjun, Du Min, Wan Hongping, Yang Hao, Deng Xiaorong, Chen Yu, Zhang Qian   +6 more
doaj   +1 more source

Increased expression of autophagy and Nrf2-dependent signaling pathway genes by new monophenolic antioxidants depends on their structure

Сибирский научный медицинский журнал, 2021
Under certain conditions, both activators and inhibitors of Nrf2-dependent signaling and autophagy can serve as potential agents for the prevention, treatment, and maintenance therapy of cancer, as well as overcoming chemoresistance.
S. E. Khrapov, P. M. Kozhin, M. V. Khrapova, A. E. Serykh, L. P. Romakh, V. S. Pavlov, A. V. Chechushkov, S. V. Kholshin, N. K. Zenkov, E. B. Menshchikova   +9 more
doaj   +1 more source

Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone [PDF]

, 2020
Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1.
Boothman, David A., DeNicola, Gina M., Elkins, Cody M., Falzone, Aimee, Haura, Eric B., Prieto-Farigua, Nicolas, Torrente, Laura   +6 more
core   +1 more source

KEAP1/NRF2 as a druggable target [PDF]

Arhiv za farmaciju, 2023
Nuclear factor erythroid 2-related factor 2 (NRF2; encoded by NFE2L2) is an inducible transcription factor that regulates the expression of a large network of genes encoding proteins with cytoprotective functions.
Dinkova-Kostova Albena T.
doaj  

In Silico Analysis Determining the Binding Interactions of NAD(P)H: Quinone Oxidoreductase 1 and Resveratrol via Docking and Molecular Dynamic Simulations

European Journal of Biology, 2023
Objective: NAD(P)H: Quinone oxidoreductase1 (NQO1) plays a crucial role in cellular defense against oxidative stress. Overexpression of NQO1 is linked to various cancer pathways.
Santosh Kumar Behera, Christoffer B Lambring, Albina Hashmi, Sriharika Gottipolu, Riyaz Basha   +4 more
doaj   +1 more source

Upregulation of p53 by tannic acid treatment suppresses the proliferation of human colorectal carcinoma

Acta Pharmaceutica, 2021
The present study’s objective is to clarify the molecular mechanisms of tannic acid effects on the viability of human colorectal carcinoma (CRC). Tannic acid is stable for up to 48 h and is localized in both cytoplasm and nucleus.
Karakurt Serdar, Kandir Sinan, Gökçek-Saraç Çiğdem   +2 more
doaj   +1 more source

Candidate genes of the development of antipsychotic-induced parkinsonism in patients with schizophrenia

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2021
Antipsychotic-induced parkinsonism is an undesirable reaction from the extrapyramidal system that occurs against the background of taking antipsychotics (AP), more often in patients with schizophrenia.
E. E. Vaiman, N. A. Shnayder, N. G. Neznanov, R. F. Nasyrova   +3 more
doaj   +1 more source

Oxidative stress in Duchenne muscular dystrophy: focus on the NRF2 redox pathway [PDF]

, 2017
Oxidative stress is involved in the pathogenesis of Duchenne muscular dystrophy (DMD), an X-linked genetic disorder caused by mutations in the dystrophin gene and characterized by progressive, lethal muscle degeneration and chronic inflammation.
Bertini, Enrico, Catteruccia, Michela, D'Amico, Adele, FORCINA, LAURA, MUSARO', Antonio, PELOSI, LAURA, Petrillo, Sara, Petrini, Stefania, Piemonte, Fiorella, Travaglini, Lorena, Verardo, Margherita   +10 more
core   +5 more sources