Results 31 to 40 of about 33,318 (195)

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]

, 2019
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo, Bingqi Tong, BR Stockwell, Breanna Ford, Daniel K. Nomura, DL Tribble, DW Morgens, I Ingold, James A. Olzmann, JL Macdonald, Joseph M. Hendricks, K Bersuker, K Shimada, Kirill Bersuker, KR Marshall, L Magtanong, Leslie Magtanong, M Hayano, M Wu, Melissa A. Roberts, MG Rees, Michael C. Bassik, MJ Hangauer, Peter H. Tang, PH Tang, R Stocker, Roberto Zoncu, Scott J. Dixon, SJ Dixon, SJ Dixon, SJ Dixon, T Inoue, T Inoue, T Takahashi, TB Nguyen, Thomas J. Maimone, VS Viswanathan, WS Yang, WS Yang, X Sun, Y Ohiro, Y Zhang, Y Zou, Zhipeng Li   +43 more
core   +1 more source

Augmentation of NAD+ by Dunnione Ameliorates Imiquimod-Induced Psoriasis-Like Dermatitis in Mice

Journal of Inflammation Research, 2022
Seung Hoon Lee,1,* Hyung-Jin Kim,1,* Gi-Su Oh,1 Su-Bin Lee,1 Dipendra Khadka,1 Wal Cao,1 Seong-Kyu Choe,1 Hyeok Shim,2 Chang-Deok Kim,3 Tae Hwan Kwak,4 Hong-Seob So1,4 1Department of Microbiology, Wonkwang University School of Medicine, Iksan ...
Lee SH, Kim HJ, Oh GS, Lee SB, Khadka D, Cao W, Choe SK, Shim H, Kim CD, Kwak TH, So HS   +10 more
doaj  

Severe and prolonged myelosuppression during concomitant temozolomide and radiotherapy treatment in a patient with glioblastoma multiforme [PDF]

, 2015
Aims: We describe the case of a patient with glioblastoma (GBM) who developed severe and prolonged myelosuppression during concomitant daily temozolomide (TMZ) and radiotherapy (RT) treatment.
ALOE SPIRITI, Maria Antonietta, Carnevale, Alessia, Cox, Maria, DE SANCTIS, Vitaliana, Gentile, Giovanna, MAURIZI ENRICI, Riccardo, Minniti, Giuseppe, Porrini, ì Raffaele, Ruco, Luigi, Scaringi, Claudia, Simmaco, Maurizio, Tafuri, Agostino, Valeriani, Maurizio   +12 more
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Viral delivery of antioxidant genes as a therapeutic strategy in experimental models of amyotrophic lateral sclerosis. [PDF]

, 2013
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder with no effective treatment to date. Despite its multi-factorial aetiology, oxidative stress is hypothesized to be one of the key pathogenic mechanisms.
Azzouz, M, Higginbottom, A, Nanou, A, Ning, K, Shaw, P, Valori, CF, Wyles, M   +6 more
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Influence of NQO1 Polymorphisms on Warfarin Maintenance Dose: A Systematic Review and Meta-Analysis (rs1800566 and rs10517)

Cardiovascular Therapeutics, 2021
This meta-analysis was conducted to analyze the effect of NQO1 polymorphism on the warfarin maintenance dosage. Using strict inclusion and exclusion criteria, we searched PubMed, EMBASE, and the Cochrane Library for eligible studies published prior to ...
Lihong Tian, Pingping Xiao, Bingrong Zhou, Yishan Chen, Lijuan Kang, Qingqing Wang, Jianfeng Lin, Min Son, Qingxiu Wu   +8 more
doaj   +1 more source

Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy

Molecules, 2021
NAD(P)H:quinone acceptor oxidoreductase-1 (NQO1) is a ubiquitous flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory two-electron reductions of quinones, quinonimines, nitroaromatics, and azo dyes.
Bhargav Shreevatsa, Chandan Dharmashekara, Vikas Halasumane Swamy, Meghana V. Gowda, Raghu Ram Achar, Vivek Hamse Kameshwar, Rajesh Kumar Thimmulappa, Asad Syed, Abdallah M. Elgorban, Salim S. Al-Rejaie, Joaquín Ortega-Castro, Juan Frau, Norma Flores-Holguín, Chandan Shivamallu, Shiva Prasad Kollur, Daniel Glossman-Mitnik   +15 more
doaj   +1 more source

NQO1/CPT1A promotes the progression of pancreatic adenocarcinoma via fatty acid oxidation

Acta Biochimica et Biophysica Sinica, 2023
NQO1, a cytosolic enzyme, is closely related to the progression of cancers and poor outcome of cancer patients. However, the molecular biological mechanism of NQO1 tumorigenicity in pancreatic adenocarcinoma (PAAD) has not been clearly understood.
Xu Ran, Liu Ying, Ma Liang, Sun Yao, Liu Haifeng, Yang Yang, Jin Tiefeng, Yang Dawei   +7 more
doaj   +1 more source

Investigation of NQO1 genetic polymorphism, NQO1 gene expression and PAH-DNA adducts in ESCC. A case-control study from Iran [PDF]

, 2009
We evaluated the effect of NQO1 genetic variation on PAH-DNA adducts in esophageal squamous cell carcinoma (ESCC) in northeast Iran. Golestan Province in northeast of Iran has one of the highest esophageal cancer incidences in the world.
Biramijamal, F., Hossein-Nezhad, A., Malekzadeh, R., Marjani, H.A., Rakhshani, N.   +4 more
core   +3 more sources

Collaborative Effects of Caloric Restriction and Quercetin on Age-related Oxidative Stress Reduction through NQO1/Sirt1 Gene Regulation

International Journal of Preventive Medicine
Background: Aging is caused by the progressive accumulation of various changes in the body, which is associated with an increase in free radicals and oxidative stress (OS). The aim of this study was to investigate the potential of caloric restriction (CR)
Fereshte Ghorbani, Arezou Biyabani, Darya Ghadimi, Keivan Nedaei, Hadi Khodabandehloo, Mina Hemmati   +5 more
doaj   +1 more source

Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2 [PDF]

, 2016
Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury.
Ciechanowicz, S, Ji, X, Ma, D, Mitchell, S, Savage, S, Wang, T, Zhao, H   +6 more
core   +1 more source