Results 21 to 30 of about 33,318 (195)
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2022 Limin Yan1 *, Dedong Xu2 *, Ying Xiao,1 Mingming Dai,1 Ting Wang,1 Xinhong Zhuang,3 Kunliang Wu4 1Department of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, People’s Republic of China; 2Department of ...
Yan L +6 more
doaj
Redox modulation of NQO1. [PDF]
PLoS ONE, 2018 NQO1 is a FAD containing NAD(P)H-dependent oxidoreductase that catalyzes the reduction of quinones and related substrates. In cells, NQO1 participates in a number of binding interactions with other proteins and mRNA and these interactions may be ...
David Siegel +9 more
doaj +1 more source
Current Research in Toxicology, 2023 The detoxification of quinones through NAD(P)H:quinone oxidoreductase (NQO1) is a crucial mechanism to maintain cellular homeostasis. The exposure to heavy metals, specifically methylmercury (MeHg), induces several antioxidant enzymes, including NQO1 ...
Mohammed A. Alqahtani +3 more
doaj +1 more source
The diverse functionality of NQO1 and its roles in redox control
Redox Biology, 2021 In this review, we summarize the multiple functions of NQO1, its established roles in redox processes and potential roles in redox control that are currently emerging.
David Ross, David Siegel
doaj +1 more source
NQO2 is a reactive oxygen species generating off-target for acetaminophen [PDF]
, 2014 [Image: see text] The analgesic and antipyretic compound acetaminophen (paracetamol) is one of the most used drugs worldwide. Acetaminophen overdose is also the most common cause for acute liver toxicity.
Ahn K. S. +45 more
core +4 more sources
A Model for NAD(P)H: Quinoneoxidoreductase 1 (NQO1) Targeted Individualized Cancer Chemotherapy
Drug Target Insights, 2009 NQO1 (NAD(P)H:quinoneoxidoreductase 1) is a reductive enzyme that is an important activator of bioreductive antitumor agents. NQO1 activity varies in individual tumors but is generally higher in tumor cells than in normal cells.
Asher Begleiter +5 more
doaj +4 more sources
NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells. [PDF]
PLoS ONE, 2012 NAD(P)H:quinone oxidoreductase 1 (NQO1) is an FAD containing quinone reductase that catalyzes the 2-electron reduction of a broad range of quinones. The 2-electron reduction of quinones to hydroquinones by NQO1 is believed to be a detoxification process ...
David Siegel, Jadwiga K Kepa, David Ross
doaj +1 more source
NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]
, 2018 Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena +19 more
core +1 more source
NQO1 Enzyme and its Role in Cellular Protection; an Insight
Iberoamerican Journal of Medicine, 2020 NAD(P)H:quinone oxidoreductase 1 (NQO1) is considered as one of the most significant enzyme in cellular defense due to its ability to detoxify reactive quinones and quinone imines to their less toxic hydroquinones forms. NQO1 is a xenobiotic metabolizing
Ahmed Atia, Azman Abdullah
doaj +1 more source