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The Cancer Journal, 2012
Cutaneous melanomas have mutations in the NRAS GTPase in 15% of cases. Compared to melanomas with BRAF mutations, or melanomas "wild-type" for BRAF and NRAS, melanomas with NRAS mutations are more likely to be thicker tumors and to have a higher mitotic rate. Preclinical studies indicate that melanoma cells with NRAS mutations are dependent on NRAS for
Fergal C, Kelleher, Grant A, McArthur
openaire +2 more sources
Cutaneous melanomas have mutations in the NRAS GTPase in 15% of cases. Compared to melanomas with BRAF mutations, or melanomas "wild-type" for BRAF and NRAS, melanomas with NRAS mutations are more likely to be thicker tumors and to have a higher mitotic rate. Preclinical studies indicate that melanoma cells with NRAS mutations are dependent on NRAS for
Fergal C, Kelleher, Grant A, McArthur
openaire +2 more sources
Journal of the American Statistical Association, 1937
Collis Stocking, Charles Fredrick Roos
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Collis Stocking, Charles Fredrick Roos
+4 more sources
Investigating the NRAS 5′ UTR as a target for small molecules
Cell Chemical Biology, 2023Sumirtha Balaratnam +2 more
exaly
Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis
Cell, 2019Chengqian Yin +2 more
exaly