Results 21 to 30 of about 42,485 (284)

BRAF, NRAS, KIT, TERT, GNAQ/GNA11 Mutation Profile and Histomorphological Analysis of Anorectal Melanomas: A Clinicopathologic Study

Türk Patoloji Dergisi, 2023
Objective: Primary anorectal melanomas (AMs) are uncommon neoplasms with aggressive behavior. Molecular profile and clinicopathologic features of AMs are still not well established.
Orhun Cig TASKIN, Sule OZTURK SARI, Ismail YILMAZ, Ozge HURDOGAN, Metin KESKIN, Nesimi BUYUKBABANI, Mine GULLUOGLU   +6 more
doaj   +1 more source

Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells [PDF]

, 2016
In melanoma, mutant and thereby constantly active neuroblastoma rat sarcoma (NRAS) affects 15-20% of tumors, contributing to tumor initiation, growth, invasion, and metastasis. Recent therapeutic approaches aim to mimic RAS extinction by interfering with
Posch, Christian, Kim, Sarasa T, Esteve-Puig, Rosaura, Vujic, Igor, Chand, Shreya, Green, Gary, Ortiz-Urda, Susana, Oses-Prieto, Juan A, Lai, Kevin, Zekhtser, Mitchell, Panzer-Grümayer, Renate, Cholewa, Brian D, Rappersberger, Klemens, Ma, Jeffrey, Burlingame, Alma L, Sanlorenzo, Martina   +15 more
core   +1 more source

Current Perspectives and Novel Strategies of NRAS-Mutant Melanoma [PDF]

, 2021
Inhibidor de MEK; Mutació NRAS; Melanoma metastàticInhibidor de MEK; Mutación NRAS; Melanoma metastásicoMEK inhibitor; NRAS mutation; Metastatic melanomaMelanoma is the deadliest cutaneous cancer.
Garcia-Alvarez, Alejandro, Muñoz Couselo, Eva, Ortiz Velez, Carolina   +2 more
core   +1 more source

Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer

Archives of Medical Science, 2021
Introduction Detection of abnormalities in the KRAS, NRAS and BRAF genes is extremely important for proper qualification of colorectal cancer (CRC) patients for therapy with anti-EGFR (epidermal growth factor receptor) monoclonal antibodies.
Aleksandra Bożyk, Paweł Krawczyk, Katarzyna Reszka, Kinga Krukowska, Agnieszka Kolak, Sławomir Mańdziuk, Kamila Wojas-Krawczyk, Rodryg Ramlau, Janusz Milanowski   +8 more
doaj   +1 more source

Characteristics of NSCLCs harboring NRAS mutations [PDF]

, 2012
7532 Background: We sought to determine the frequency and clinical characteristics of patients with non-small cell lung cancers (NSCLCs) harboring NRAS mutations.
Sos, Martin, Rudin, Charles M, Bunn, Paul A, Pao, William, Ohashi, Kadoaki, Chen, Xi, Franklin, Wilbur A, Sequist, Lecia V, Ladanyi, Marc, Dias-Santagata, Dora, Riely, Gregory J, Kris, Mark G, Moran, Teresa, Vnencak-Jones, Cindy L, Arcila, Maria E, Sasaki, Hidefumi, Lovly, Christine Marie, Camidge, D. Ross, Dubinett, Steven M   +18 more
core   +1 more source

KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer – practical implications for the clinician

Radiology and Oncology, 2019
Colorectal cancer is a successful model of genetic biomarker development in oncology. Currently, several predictive or prognostic genetic alterations have been identified and are used in clinical practice.
Afrăsânie Vlad-Adrian, Marinca Mihai Vasile, Alexa-Stratulat Teodora, Gafton Bogdan, Păduraru Marius, Adavidoaiei Anca Maria, Miron Lucian, Rusu Cristina   +7 more
doaj   +1 more source

miR-145-5p suppresses cell proliferation by targeting IGF1R and NRAS genes in multiple myeloma cells

Türk Biyokimya Dergisi, 2023
Multiple myeloma (MM) is a common hematological cancer. Hence, it is important to conduct further studies investigating the molecular mechanisms in detail that contributes to myeloma genesis.
Kaya Murat, Suer Ilknur, Ozgur Emre, Capik Ozel, Karatas Omer Faruk, Ozturk Sukru, Gezer Ugur, Palanduz Sukru, Cefle Kivanc   +8 more
doaj   +1 more source

Molecular-genetic mechanisms of the signal cascade RAS-RAF-MEK-ERK associated with the development of the tumor process and the purpose of targeted drugs for colorectal cancer

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Colorectal cancer occupies one of the leading positions in the world in the structure of cancer incidence. The vital processes of cancer cells largely depend on the production of growth factors and their receptors. One of these is epidermal growth factor
A. N. Toropovsky, O. N. Pavlova, D. A. Viktorov, A. G. Nikitin   +3 more
doaj   +1 more source

The combination of mutations in BRAF and NRAS genes within a one tumor in patients with cutaneous melanoma

Бюллетень сибирской медицины, 2019
The paper provides a clinical description and analysis of two melanoma cases with mutations in the BRAF and NRAS gene within one tumor. Until recently, it was believed that mutations in the BRAF and NRAS genes are exclusive and do not occur within the ...
M. B. Aksenenko, A. S. Averchuk, T. G. Ruksha   +2 more
doaj   +1 more source

NRAS Mutations in Noonan Syndrome [PDF]

, 2012
Noonan syndrome is a genetically heterogeneous disorder caused by mutations in PTPN11, SOS1, RAF1 and less frequently in KRAS, NRAS or SHOC2. Here, we performed mutation analysis of NRAS and SHOC2 in 115 PTPN11, SOS1, RAF1, and KRAS mutation-negative ...
Peeters, Hilde, Legius, Eric, Denayer, Ellen, Sevenants, L., Derbent, M., Fryns, Jean-Pierre   +5 more
core   +1 more source