Results 21 to 30 of about 45,512 (293)

Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2α Kinase Levels in NRAS(Q61) Mutant Cells [PDF]

, 2016
In melanoma, mutant and thereby constantly active neuroblastoma rat sarcoma (NRAS) affects 15-20% of tumors, contributing to tumor initiation, growth, invasion, and metastasis. Recent therapeutic approaches aim to mimic RAS extinction by interfering with
Posch, Christian, Kim, Sarasa T, Esteve-Puig, Rosaura, Vujic, Igor, Chand, Shreya, Green, Gary, Ortiz-Urda, Susana, Oses-Prieto, Juan A, Lai, Kevin, Zekhtser, Mitchell, Panzer-Grümayer, Renate, Cholewa, Brian D, Rappersberger, Klemens, Ma, Jeffrey, Burlingame, Alma L, Sanlorenzo, Martina   +15 more
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Targeting NRAS mutant melanomas through metabolic stress [PDF]

, 2021
Al melanoma cutani, els gens que presenten una major incidència mutacional són els gens BRAF i NRAS. Alteracions en aquests gens resulten en l'activació constitutiva de la via de RAS-ERK1/2, contribuint activament així en el desenvolupament i la ...
Mc Grail Fernández, Kimberley Anne
core   +2 more sources

Correlation between KRAS, NRAS and BRAF mutations and tumor localizations in patients with primary and metastatic colorectal cancer

Archives of Medical Science, 2021
Introduction Detection of abnormalities in the KRAS, NRAS and BRAF genes is extremely important for proper qualification of colorectal cancer (CRC) patients for therapy with anti-EGFR (epidermal growth factor receptor) monoclonal antibodies.
Aleksandra Bożyk, Paweł Krawczyk, Katarzyna Reszka, Kinga Krukowska, Agnieszka Kolak, Sławomir Mańdziuk, Kamila Wojas-Krawczyk, Rodryg Ramlau, Janusz Milanowski   +8 more
doaj   +1 more source

KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer – practical implications for the clinician

Radiology and Oncology, 2019
Colorectal cancer is a successful model of genetic biomarker development in oncology. Currently, several predictive or prognostic genetic alterations have been identified and are used in clinical practice.
Afrăsânie Vlad-Adrian, Marinca Mihai Vasile, Alexa-Stratulat Teodora, Gafton Bogdan, Păduraru Marius, Adavidoaiei Anca Maria, Miron Lucian, Rusu Cristina   +7 more
doaj   +1 more source

miR-145-5p suppresses cell proliferation by targeting IGF1R and NRAS genes in multiple myeloma cells

Türk Biyokimya Dergisi, 2023
Multiple myeloma (MM) is a common hematological cancer. Hence, it is important to conduct further studies investigating the molecular mechanisms in detail that contributes to myeloma genesis.
Kaya Murat, Suer Ilknur, Ozgur Emre, Capik Ozel, Karatas Omer Faruk, Ozturk Sukru, Gezer Ugur, Palanduz Sukru, Cefle Kivanc   +8 more
doaj   +1 more source

Molecular-genetic mechanisms of the signal cascade RAS-RAF-MEK-ERK associated with the development of the tumor process and the purpose of targeted drugs for colorectal cancer

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021
Colorectal cancer occupies one of the leading positions in the world in the structure of cancer incidence. The vital processes of cancer cells largely depend on the production of growth factors and their receptors. One of these is epidermal growth factor
A. N. Toropovsky, O. N. Pavlova, D. A. Viktorov, A. G. Nikitin   +3 more
doaj   +1 more source

The combination of mutations in BRAF and NRAS genes within a one tumor in patients with cutaneous melanoma

Бюллетень сибирской медицины, 2019
The paper provides a clinical description and analysis of two melanoma cases with mutations in the BRAF and NRAS gene within one tumor. Until recently, it was believed that mutations in the BRAF and NRAS genes are exclusive and do not occur within the ...
M. B. Aksenenko, A. S. Averchuk, T. G. Ruksha   +2 more
doaj   +1 more source

Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS [PDF]

Royal Society Open Science, 2018
The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell ...
Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Ruan   +4 more
doaj   +1 more source

Novel treatment strategy for NRAS-mutated melanoma through a selective inhibitor of CD147/VEGFR-2 interaction

, 2022
More than 70% of human NRAS melanomas are resistant to MEK inhibitors highlighting the crucial need for efficient therapeutic strategies for these tumors.
Menash, Suzanne, Lebbe, Céleste, Mourah, Samia, Fernández-Recio, Juan, Battistella, Maxime, Sadoux, Aurélie, Villoutreix, Bruno O., Dumaz, Nicolas, Landras, Alexandra, Reger De Moura, Coralie   +9 more
core   +1 more source

KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer

International Journal of General Medicine, 2023
Juanzi Zeng,1,2 Wenwei Fan,3 Jiaquan Li,1,2 Guowu Wu,1,2 Heming Wu2 1Department of Medical Oncology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Center for Precision Medicine, Meizhou People’s ...
Zeng J, Fan W, Li J, Wu G, Wu H
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