Results 31 to 40 of about 42,485 (284)

KRAS/NRAS Mutations Associated with Distant Metastasis and BRAF/PIK3CA Mutations Associated with Poor Tumor Differentiation in Colorectal Cancer

International Journal of General Medicine, 2023
Juanzi Zeng,1,2 Wenwei Fan,3 Jiaquan Li,1,2 Guowu Wu,1,2 Heming Wu2 1Department of Medical Oncology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Center for Precision Medicine, Meizhou People’s ...
Zeng J, Fan W, Li J, Wu G, Wu H
doaj  

Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS [PDF]

Royal Society Open Science, 2018
The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell ...
Xiaoyan Liu, Yu Zhang, Su Wang, Guoying Liu, Liming Ruan   +4 more
doaj   +1 more source

Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma. [PDF]

Clin Exp Dermatol
Background: NRAS and KIT mutations in melanoma bring implications for prognosis, follow-up, selection into trials and potential future treatment with targeted therapies.
Mistry K, Jeffrey P, Levell NJ, Kennedy O, Richardson K, Craig P, Bright C, Taylor S, Ragan J, Karponis D, Pethick J, Lavelle K, McRonald F, Hardy S, Vernon S, Dawe R, Proby C, Lorigan P, Venables ZC.   +18 more
europepmc   +2 more sources

PROGNOSTIC SIGNIFICANCE OF NRAS GENE MUTATIONS IN CHILDREN WITH ACUTE MYELOGENOUS LEUKEMIA

Mediterranean Journal of Hematology and Infectious Diseases, 2011
Background: NRAS mutations are the most commonly detected molecular abnormalities  in hematologic malignancies, especially in those of myeloid origin.
Rabab Aly, Mohamed R. El-sharnoby, Adel A. Hagag   +2 more
doaj   +3 more sources

The frequency of NRAS mutation in stool samples of Iranian colorectal cancers compared to Finnish patients

Journal of Research in Medical Sciences
Background: Stools from colorectal cancer patients are noninvasive samples that could be used to compare the frequency of hotspot mutations between two different ethnic cohorts.
Farideh Saberi, Omar Youssef, Arto Kokkola, Mahsa Khodadoostan, Pauli Puolakkainen, Rasoul Salehi, Sakari Knuutila   +6 more
doaj   +1 more source

NRas activity is regulated by dynamic interactions with nanoscale signaling clusters at the plasma membrane

iScience, 2022
Summary: NRas is a key mediator of the mitogenic pathway in normal cells and in cancer cells. Its dynamics and nanoscale organization at the plasma membrane (PM) facilitate its signaling.
Oren Yakovian, Julia Sajman, Michal Alon, Rand Arafeh, Yardena Samuels, Eilon Sherman   +5 more
doaj   +1 more source

Targeting NRAS mutant melanomas through metabolic stress [PDF]

, 2021
Al melanoma cutani, els gens que presenten una major incidència mutacional són els gens BRAF i NRAS. Alteracions en aquests gens resulten en l'activació constitutiva de la via de RAS-ERK1/2, contribuint activament així en el desenvolupament i la ...
Mc Grail Fernández, Kimberley Anne
core  

MicroRNA-708 emerges as a potential candidate to target undruggable NRAS.

PLoS ONE, 2023
RAS, the most frequently mutated oncogene that drives tumorigenesis by promoting cell proliferation, survival, and motility, has been perceived as undruggable for the past three decades.
Jia Meng Pang, Po-Chen Chien, Ming-Chien Kao, Pei-Yun Chiu, Pin-Xu Chen, Yu-Ling Hsu, Chengyang Liu, Xiaowei Liang, Kai-Ti Lin   +8 more
doaj   +1 more source

Playing Polo-Like Kinase in NRAS-Mutant Melanoma [PDF]

, 2015
NRAS-mutant melanomas are extremely aggressive and highly resistant to currently available therapeutic modalities. Hence, new targets and therapeutic strategies for NRAS-driven melanomas are needed.
Chen, Hsin-Yi, Villanueva, Jessie
core   +1 more source

The opposite association of HRAS and KRAS mutations with clinical variables of bladder cancer

Вавиловский журнал генетики и селекции, 2015
HRAS, KRAS and NRAS gene products belong to the superfamily of small GTPases. These proteins regulate cellular response to extracellular stimuli by means of activation of different signaling pathways.
M. P. Smal, A. I. Rolevich, T. N. Nabebina, S. A. Krasny, R. I. Goncharova   +4 more
doaj   +1 more source