Results 31 to 40 of about 69,773 (297)
Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2021 Colorectal cancer occupies one of the leading positions in the world in the structure of cancer incidence. The vital processes of cancer cells largely depend on the production of growth factors and their receptors. One of these is epidermal growth factor
A. N. Toropovsky +3 more
doaj +1 more source
The South African Medicines Control Council: Comparison of Its Registration Process With Australia, Canada, Singapore, and Switzerland [PDF]
, 2019 © 2019 Keyter, Salek, Banoo and Walker.Introduction: Comparisons between regulatory authorities of similar size and regulatory characteristics facilitate value-added benchmarking and provide insight into regulatory performance. Such comparisons highlight
Banoo, Shabir +3 more
core +2 more sources
Loss of miR-143 and miR-145 in condyloma acuminatum promotes cellular proliferation and inhibits apoptosis by targeting NRAS [PDF]
Royal Society Open Science, 2018 The expression profile of miRNAs and their function in condyloma acuminatum (CA) remains unknown. In this study, we aimed to detect the effects of miR-143 and miR-145, the most downregulated in CA samples using high-throughput sequencing, on cell ...
Xiaoyan Liu +4 more
doaj +1 more source
Overcoming steroid resistance in T cell acute lymphoblastic leukemia [PDF]
, 2016 In a Perspective, Pieter Van Vlierberghe and Steven Goossens discuss Meijerink and colleagues' findings on steroid resistance in pediatric T cell acute lymphoblastic ...
Goossens, Steven +1 more
core +3 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The opposite association of HRAS and KRAS mutations with clinical variables of bladder cancer
Вавиловский журнал генетики и селекции, 2015 HRAS, KRAS and NRAS gene products belong to the superfamily of small GTPases. These proteins regulate cellular response to extracellular stimuli by means of activation of different signaling pathways.
M. P. Smal +4 more
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Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
A catalogue of nuclear stellar velocity dispersions of nearby galaxies from \u2009H\u3b1 STIS spectra to constrain supermassive black hole masses [PDF]
, 2018 We present new measurements for the nuclear stellar velocity dispersion \u3c3* within sub-arcsecond apertures for 28 nearby galaxies. Our data consist of Space Telescope Imaging Spectrograph (STIS) long-slit spectra obtained with the G750M grating ...
Bont\ue0, Elena +7 more
core +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Frontiers in Medicine, 2023 IntroductionNRAS mutations are common in melanoma and confer a worse prognosis. Although most patients with metastatic melanoma receive immune checkpoint inhibitors (ICIs), the impact of NRAS mutational status on their efficacy remains under debate ...
Zachary J. Jaeger +8 more
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