Results 51 to 60 of about 42,485 (284)

Cutis Verticis Gyrata Differential Diagnosis: Clinical Case

Вопросы современной педиатрии
Background. Cutis verticis gyrata is rare benign scalp disorder characterized by excessive skin and subcutaneous tissue proliferation and hypertrophy. Nowadays, there are three forms of this disease with various developmental mechanisms and associated ...
Tatiana S. Belysheva, Ekaterina E. Zelenova, Tatiana A. Gassan, Eduard T. Ambarchyan, Malika I. Denieva, Yana V. Vishnevskaya, Tatiana V. Nasedkina, Nikolay N. Murashkin   +7 more
doaj   +1 more source

Elevated NRAS expression during DCIS is a potential driver for progression to basal-like properties and local invasiveness

Breast Cancer Research, 2022
Background Ductal carcinoma in situ (DCIS) is the most common type of in situ premalignant breast cancers. What drives DCIS to invasive breast cancer is unclear. Basal-like invasive breast cancers are aggressive.
Ze-Yi Zheng, Hanan Elsarraj, Jonathan T. Lei, Yan Hong, Meenakshi Anurag, Long Feng, Hilda Kennedy, Yichao Shen, Flora Lo, Zifan Zhao, Bing Zhang, Xiang H.-F. Zhang, Ossama W. Tawfik, Fariba Behbod, Eric C. Chang   +14 more
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

NRAS is the direct target of miR-708. [PDF]

, 2023
(A) Cancer cell lines with NRAS mutation used in this study. (B) Left: Representative Western blot of NRAS protein expression in SK-MEL-2, THP-1, and H1299 cells transfected with mock, scrambled control (s.c.), and precursor miR-708 (pre-miR-708) for 48 ...
Xiaowei Liang (4721025), Pin-Xu Chen (15338703), Pei-Yun Chiu (15338700), Jia Meng Pang (15338691), Ming-Chien Kao (15338697), Yu-Ling Hsu (309981), Chengyang Liu (11406281), Kai-Ti Lin (4093594), Po-Chen Chien (15338694)   +8 more
core   +1 more source

miR-6824-3p suppresses hepatitis B virus replication by targeting NRAS to regulate TNF-α secretion in macrophages

Zhongguo shuxue zazhi
[Objective] To investigate the regulatory role of miR-6824-3p in macrophage function and its molecular mechanism in inhibiting hepatitis B virus (HBV) replication, thereby providing experimental evidence to elucidate the immune regulatory mechanisms ...
LIN Simin, CHEN Limin, LI Yujia, LI Shilin   +3 more
doaj   +1 more source

Detection of Mutations in Selected Proto-Oncogenes of Canine Lymphoma

Folia Veterinaria, 2017
Lymphomas belong among the most frequently diagnosed tumours of the haematopoietic system in dogs. The clinical manifestations and genetic and molecular basis of canine lymphoma resembles those of human non-Hodgkin lymphoma and therefore it can serve as ...
Bóna G., Šiviková K.
doaj   +1 more source

NRAS mutant melanoma - undrugable?

Oncotarget, 2013
Mutations in the three rat sarcoma (RAS) family members NRAS (neuroblastoma-RAS), HRAS (Harvey-RAS) and KRAS (Kirsten-RAS) are found in one third of human cancers. Among the first oncogenes discovered in cutaneous melanoma was NRAS, which is mutant in up to 20% of tumors causing aberrant signaling in several downstream cascades. Despite, being a highly
Christian, Posch, Susana, Ortiz-Urda
openaire   +3 more sources

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity [PDF]

, 2018
Mutations in epigenetic modifiers and signaling factors often co-occur in myeloid malignancies, including TET2 and NRAS mutations. Concurrent Tet2 loss and NrasG12D expression in hematopoietic cells induced myeloid transformation, with a fully penetrant,
Nazir, Abbas, Justin Whitfield, Francine E. Garrett-Bakelman, Alan H. Shih, Cem Meydan, Ross L. Levine, Rebecca Maher, Melnick, Ari, Martin Tallman, Ari Melnick, Meyer, Sara C., Shih, Alan H, Levine, Ross L, Kunimoto, Hiroyoshi, Sara C. Meyer, Whitfield, Justin, Shank, Kaitlyn, Garrett-Bakelman, Francine E, Abbas Nazir, Rapaport, Franck, Franck Rapaport, Tallman, Martin, Hiroyoshi Kunimoto, Kaitlyn Shank, Elodie Pronier, Pronier, Elodie, Meydan, Cem, Maher, Rebecca   +27 more
core   +1 more source

Translational Gap in Biomarker Discovery: Tumor Surface Markers Rarely Mirror Circulating Levels

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Tumor‐associated cell surface proteins are frequently proposed as circulating biomarkers for colorectal cancer (CRC) based on their high tumor expression. However, many candidates identified through tissue‐based analyses fail to translate into clinically useful biomarkers.
Junko Mukohyama, Shohei F. Fujita, Xinyi Fu, Shigenori Suzuki, Hiroki Hamamoto, Dai Shida, Kimihiro Yamashita, Kohei Taniguchi, Sang‐Woong Lee, Akihide Yoshimi   +9 more
wiley   +1 more source