Results 51 to 60 of about 1,590 (205)
Scientific Reports, 2021 Circular RNAs have emerged as functional regulatory molecules whose aberrant expression has been linked to diverse pathophysiological processes. Here, we report that circPVT1 interferes with let-7 binding to NRAS, confirming this axis as one route by ...
Joshua Miguel C. Danac +1 more
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The 9th International RASopathies Symposium
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT The RASopathies are a group of congenital disorders with overlapping clinical manifestations that are caused by pathogenic germline or early somatic variants that result in the hyperactivation of the RAS/mitogen‐activated protein kinase (MAPK) signaling pathway.
Pau Castel +41 more
wiley +1 more source
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma
Nature CommunicationsActivating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K,
Yalei Wen +18 more
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Detection of Mutations in Selected Proto-Oncogenes of Canine Lymphoma
Folia Veterinaria, 2017 Lymphomas belong among the most frequently diagnosed tumours of the haematopoietic system in dogs. The clinical manifestations and genetic and molecular basis of canine lymphoma resembles those of human non-Hodgkin lymphoma and therefore it can serve as ...
Bóna G., Šiviková K.
doaj +1 more source
Cell Communication and SignalingNRAS mutations are most frequently observed in hematological malignancies and are also common in some solid tumors such as melanoma and colon cancer.
Chenxuan Liu +11 more
doaj +1 more source
Segmental composition and nerve distribution of the brachial plexus in Galictis cuja
The Anatomical Record, EarlyView.Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho +6 more
wiley +1 more source
Prevalence of BRAF, NRAS and c-KIT mutations in Slovenian patients with advanced melanoma
Radiology and Oncology, 2018 BRAF, NRAS and c-KIT mutations are characteristics of tumour tissues that influence on treatment decisions in metastatic melanoma patients. Mutation frequency and their correlation with histological characteristics in Slovenian population have not been ...
Moltara Maja Ebert +6 more
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Clinical Anatomy, EarlyView.ABSTRACT For effective and safe practice, health professionals need an understanding of functional anatomy. Registration boards, councils or self‐regulating professional associations determine the standards, codes, graduate competencies and education program accreditation requirements which inform health curricula development and content.
Anita Zacharias +5 more
wiley +1 more source
Journal of Consumer Behaviour, EarlyView.ABSTRACT Political consumerism (PC) refers to consumers boycotting or deliberately buying (“buycotting”) products or brands for political, moral, or ethical reasons. This paper presents three studies that consider the intricacies of the relationship between political ideology and political consumerism.
Lara J. Greening +3 more
wiley +1 more source
Prevalence of BRAF and NRAS mutations in cutaneous melanoma patients in Taiwan
Journal of the Formosan Medical Association, 2016 BRAF and NRAS mutations have been described in melanomas among Caucasians and some Asian populations. However, few large-scale studies have investigated the status and clinical significance of BRAF and NRAS mutations in a Taiwanese population.
Yi-Shuan Sheen +6 more
doaj +1 more source