Results 71 to 80 of about 69,773 (297)
Scientific Reports, 2021 Circular RNAs have emerged as functional regulatory molecules whose aberrant expression has been linked to diverse pathophysiological processes. Here, we report that circPVT1 interferes with let-7 binding to NRAS, confirming this axis as one route by ...
Joshua Miguel C. Danac +1 more
doaj +1 more source
Young Suns Exoplanet Survey: Detection of a wide-orbit planetary-mass companion to a solar-type Sco-Cen member [PDF]
, 2019 The Young Suns Exoplanet Survey consists of a homogeneous sample of 70 young, solar-mass stars located in the Lower Centaurus-Crux subgroup of the Scorpius-Centaurus association with an average age of 15 ± 3 Myr.
Bohn, A. J. +11 more
core +3 more sources
Genetic code expansion for chemosensing and chemical actuation of biological functions
Bulletin of the Korean Chemical Society, EarlyView.Genetic code expansion (GCE) broadens the chemical repertoire for precise control of protein function in biological systems. This review highlights GCE‐based sensing and actuating systems that operate through selective interactions between noncanonical amino acids and chemical triggers.
Jieun Bae, Dong‐Hyun Kim, Minseob Koh
wiley +1 more source
Pharmacological targeting of casein kinase 1δ suppresses oncogenic NRAS-driven melanoma
Nature CommunicationsActivating mutations in NRAS account for 15–20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator of oncogenic NRAS mutations, specifically Q61R and Q61K,
Yalei Wen +18 more
doaj +1 more source
Detection of Mutations in Selected Proto-Oncogenes of Canine Lymphoma
Folia Veterinaria, 2017 Lymphomas belong among the most frequently diagnosed tumours of the haematopoietic system in dogs. The clinical manifestations and genetic and molecular basis of canine lymphoma resembles those of human non-Hodgkin lymphoma and therefore it can serve as ...
Bóna G., Šiviková K.
doaj +1 more source
Clinical Anatomy, EarlyView.ABSTRACT For effective and safe practice, health professionals need an understanding of functional anatomy. Registration boards, councils or self‐regulating professional associations determine the standards, codes, graduate competencies and education program accreditation requirements which inform health curricula development and content.
Anita Zacharias +5 more
wiley +1 more source
Cell Communication and SignalingNRAS mutations are most frequently observed in hematological malignancies and are also common in some solid tumors such as melanoma and colon cancer.
Chenxuan Liu +11 more
doaj +1 more source
The lincRNA MIRAT binds to IQGAP1 and modulates the MAPK pathway in NRAS mutant melanoma. [PDF]
, 2018 Despite major advances in targeted melanoma therapies, drug resistance limits their efficacy. Long noncoding RNAs (lncRNAs) are transcriptome elements that do not encode proteins but are important regulatory molecules.
Burlingame, Alma +18 more
core +1 more source
Eliminating artefacts in polarimetric images using deep learning [PDF]
, 2020 Polarization measurements done using Imaging Polarimeters such as the Robotic Polarimeter are very sensitive to the presence of artefacts in images. Artefacts can range from internal reflections in a telescope to satellite trails that could contaminate ...
Blinov, D. +7 more
core
Journal of Consumer Behaviour, EarlyView.ABSTRACT Political consumerism (PC) refers to consumers boycotting or deliberately buying (“buycotting”) products or brands for political, moral, or ethical reasons. This paper presents three studies that consider the intricacies of the relationship between political ideology and political consumerism.
Lara J. Greening +3 more
wiley +1 more source