Results 71 to 80 of about 1,590 (205)

Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.

PLoS ONE, 2016
High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of ...
Michael K Kiessling, Alessandra Curioni-Fontecedro, Panagiotis Samaras, Silvia Lang, Michael Scharl, Adriano Aguzzi, Derek A Oldrige, John M Maris, Gerhard Rogler   +8 more
doaj   +1 more source

The Relevance of Curative‐Intent Metastasectomy in Colorectal Cancer Patients: Real‐World Insights From a Certified Comprehensive Cancer Center in Germany

International Journal of Cancer, EarlyView.
Patients with metastatic colorectal cancer who are ineligible for upfront metastasectomy may still become candidates for secondary metastasectomy with curative intent following response to primary chemotherapy. However, most studies dichotomize metastatic colorectal cancer into resectable and unresectable disease.
Julian W. Holch, Jo‐Ann Eisenburger, Antony Weber, Iris Kammermeier‐Wehlau, Yannick Wiberg, Fabian Allmendinger, Kathrin Heinrich, Lena Weiss, C. Benedikt Westphalen, Victoria Krenmayr, Klara Dorman, Danmei Zhang, Theres Fey, Karin Berger‐Thürmel, Ulrich Wirth, Florian Kühn, Michael von Bergwelt‐Baildon, Jens Werner, Volker Heinemann   +18 more
wiley   +1 more source

When NRA

, 2020
coverage ...
openaire   +1 more source

Molecular Tumor Boards in Malignant Melanoma: Uncovering Challenges and Opportunities in a Bicenter Retrospective Analysis in Germany

International Journal of Cancer, EarlyView.
Molecular tumor boards (MTB), interdisciplinary teams that use tumor genomic data to guide personalized treatment decisions, have emerged as a promising strategy in melanoma care, although their real‐world clinical impact remains uncertain. This retrospective study evaluated advanced melanoma patients to assess molecularly guided treatment ...
Glenn Geidel, Theresa Lowinus, Patrick Metzger, Rebecca Czurda, Vincent Schipperges, Ulrike Paul, Alessandra Rünger, Julian Kött, Isabel Heidrich, Saskia Lehr, Julia Kühn, Heiko Becker, Cornelius Miething, Martin Werner, Silke Laßmann, Justus Duyster, Tilman Brummer, Ronald Simon, Winfried Alsdorf, Maximilian Christopeit, Carsten Bokemeyer, Kilian Eyerich, Stefan W. Schneider, David Rafei, Melanie Börries, Frank Meiss, Christoffer Gebhardt   +26 more
wiley   +1 more source

Evaluation of a Rapid, Fully Automated Platform for Detection of BRAF and NRAS Mutations in Melanoma

Acta Dermato-Venereologica, 2017
BRAF and NRAS genetic analyses are time-consuming and can delay treatment choices in patients with metastatic melanomas presenting with acute deterioration.
Fanny Barel, Briac Guibourg, Laetitia Lambros, Glen Le Flahec, Pascale Marcorelles, Arnaud Uguen   +5 more
doaj   +1 more source

Impact of ovarian preservation on survival for premenopausal women with early‐stage endometrial carcinoma: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Up to 14% of women with early‐stage endometrial carcinoma (EEC) are diagnosed before menopause. Although ovarian preservation (OP) within surgical staging might avoid surgical menopause, its rate remains low in clinical practice, probably because the impact of OP on survival outcomes is unclear.
Antonio Raffone, Diego Raimondo, Daniele Neola, Manuela Maletta, Marisol Doglioli, Antonio Travaglino, Carlo Ronsini, Maria Giovanna Vastarella, Stefano Ferla, Francesco Cosentino, Pasquale De Franciscis, Renato Seracchioli, Luigi Cobellis   +12 more
wiley   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, EarlyView.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Enhanced visible light photocatalytic performance of CdS sensitized TiO2 nanorod arrays decorated with Au nanoparticles as electron sinks

Scientific Reports, 2017
In this paper, we propose a nanostructure with Au nanoparticles (NPs), as electron sinks, located at the most outside layer of CdS sensitized TiO2 nanorod arrays (TiO2 NRAs/CdS/Au).
Xin Gao, Xiangxuan Liu, Zuoming Zhu, Ying Gao, Qingbo Wang, Fei Zhu, Zheng Xie   +6 more
doaj   +1 more source

Systematic Review and Meta‐Analysis of Resection Sequence in Synchronous Colorectal Liver Metastasis: Primary vs. Liver First

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background This present systematic review and meta‐analysis aims to compare overall survival (OS), disease‐free survival (DFS), morbidity and mortality outcomes in patients undergoing colorectal first (CRf) versus liver first (Lf) resections with synchronous colorectal liver metastases.
Sofoklis Mavrantonis, Omar Abou El‐Wafa, Sascha Vaghiri, Dimitrios Prassas   +3 more
wiley   +1 more source

Molecular landscape of borderline ovarian tumours: A systematic review

Open Medicine
Borderline ovarian tumours (BOTs) show intriguing characteristics distinguishing them from other ovarian tumours. The aim of the systematic review was to analyse the spectrum of molecular changes found in BOTs and discuss their significance in the ...
Sadlecki Pawel, Walentowicz-Sadlecka Malgorzata   +1 more
doaj   +1 more source