Results 91 to 100 of about 69,773 (297)
NRAS destines tumor cells to the lungs
EMBO Molecular Medicine, 2017 The lungs are frequently affected by cancer metastasis. Although NRAS mutations have been associated with metastatic potential, their exact role in lung homing is incompletely understood.
Anastasios D Giannou +19 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Background Melanomas often metastasize to the brain, leading to a significantly poor prognosis despite advances in local and systemic treatments. In clinical practice, we frequently observe varying response patterns and progression dynamics between cerebral and extra cerebral sites. Objectives This study aims to identify predictive factors for
Manuel Croix +4 more
wiley +1 more source
Cell ReportsSummary: Small GTPases of the Ras subfamily are best known for their role as proto-oncoproteins, while their function during microbial infection has remained elusive.
Stephanie S. Lehman +8 more
doaj +1 more source
The origins of active galactic nuclei obscuration: the ‘torus’ as a dynamical, unstable driver of accretion [PDF]
, 2012 Recent multiscale simulations have made it possible to follow gas inflows responsible for high-Eddington ratio accretion on to massive black holes (BHs) from galactic scales to the BH accretion disc.
Hayward, Christopher C. +3 more
core
Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective
JEADV Clinical Practice, EarlyView.Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek +3 more
wiley +1 more source
School shootings increase NRA donations
Science Advances, 2023 The United States has experienced a tragic increase in school shootings in recent years. Despite substantial media attention being paid to such incidents and widespread support for stricter gun control measures, substantial legislative action remains absent, however.
openaire +2 more sources
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose The aim was to compare the safety profiles of corticosteroids (CS), hyaluronic acid (HA), blood‐derived products based on platelet concentrates (for simplicity indicated as PRP ‐ platelet‐rich plasma ‐ being PRP the most common product), and cell‐based therapies (namely products exploiting the therapeutic function of mesenchymal ...
Alessandro Bensa +8 more
wiley +1 more source
Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.
PLoS ONE, 2016 High-risk neuroblastoma remains lethal in about 50% of patients despite multimodal treatment. Recent attempts to identify molecular targets for specific therapies have shown that Neuroblastoma RAS (NRAS) is significantly mutated in a small number of ...
Michael K Kiessling +8 more
doaj +1 more source
Molecular Carcinogenesis, EarlyView.ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha +26 more
wiley +1 more source
Geophysical Monograph Series, Page 97-104., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Daniele Cherniak +2 more
wiley +2 more sources