Results 111 to 120 of about 45,512 (293)
Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.Abstract Purpose The aim was to compare the safety profiles of corticosteroids (CS), hyaluronic acid (HA), blood‐derived products based on platelet concentrates (for simplicity indicated as PRP ‐ platelet‐rich plasma ‐ being PRP the most common product), and cell‐based therapies (namely products exploiting the therapeutic function of mesenchymal ...
Alessandro Bensa +8 more
wiley +1 more source
Preclinical efficacy of MEK inhibition in Nras-mutant AML
, 2014 Oncogenic NRAS mutations are highly prevalent in acute myeloid leukemia (AML). Genetic analysis supports the hypothesis that NRAS mutations cooperate with antecedent molecular lesions in leukemogenesis, but have limited independent prognostic ...
Sampath, Deepak +13 more
core +1 more source
Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers +5 more
wiley +1 more source
Pediatric Investigation, EarlyView.Bortezomib‐based chemotherapy achieved an 88.9% remission rate in Chinese pediatric patients with relapsed/refractory B‐cell acute lymphoblastic leukemia, enabling 62.5% of responders to bridge to transplantation, while T‐cell acute lymphoblastic leukemia showed no response.
Xingyu Zhao +5 more
wiley +1 more source
Oxidative stress‐driven metabolic reprogramming defines two subtypes of cutaneous melanoma
VIEW, EarlyView.Cutaneous melanoma exhibits substantial molecular heterogeneity, and metabolic reprogramming may contribute to differences in tumor behavior and treatment response. In this study, we integrated multi‐omics data from SKCM cohorts to identify two metabolism‐associated subtypes with distinct oxidative stress profiles, immune microenvironments, prognostic ...
Qikun Gao, Ziyi Liu, Ying Xu
wiley +1 more source
Inhibition of NRAS signaling in an in vitro model of human MLL-AF9/NRAS^G12V acute myeloid leukemia
, 2011 Objective and Hypothesis: Investigate the therapeutic potential of NRAS-targeted therapy in the human MLL-AF9 and NRASG12V-driven AML cell line THP-1 using shRNA and small molecule inhibitors.
Largaespada, David +2 more
core
Papillary Thyroid Cancer With Cutaneous Metastasis: A Case Report and Literature Review
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cutaneous metastasis of papillary thyroid carcinoma is rare, which may present as slowly growing nodules, erythematous papules, or ulcerative nodules. The pathophysiological mechanisms of skin metastasis in thyroid cancer remain unclear.
Yi‐Qing Gao +3 more
wiley +1 more source
Mutant NRAS and RAC1 signaling in melanoma
, 2017 Melanomas with mutations in the GTPases NRAS and RAC1 comprise of a particularly aggressive subset of melanoma with limited therapeutic options. Within the mutant NRAS population, targeting downstream effectors pathways, particularly the MEK-ERK1/2 ...
Vu, Ha Linh
core +1 more source
Firearm Safety in a Country of Arms
The Milbank Quarterly, EarlyView.Policy Points Firearm safety policy in the United States cannot succeed through legislation alone; effective interventions must also address the social, economic, and infrastructural conditions that shape perceptions of safety. Evidence suggests that place‐based investments can reduce violence and firearm deaths while strengthening social cohesion and ...
JONATHAN M. METZL
wiley +1 more source
Asia-Pacific Journal of Clinical Oncology, EarlyView.We report our single‐center experience of transplant outcomes with a busulfan, fludarabine and melphalan‐based conditioning regimen for children < 18 years of age. The regimen was shown to be well tolerated and effective for heavily pretreated children with high‐risk myeloid malignancies prior to allogeneic hematopoietic stem cell transplant.
Mayank Dhamija +6 more
wiley +1 more source