Results 121 to 130 of about 69,773 (297)
British Journal of Haematology, EarlyView.Summary This UK‐based retrospective analysis describes real‐world treatment patterns and outcomes in 175 patients with accelerated (AP, n = 69) or blast‐phase (BP, n = 106) ‘Philadelphia‐negative’ myeloproliferative neoplasms (MPN‐AP/BP) diagnosed between 2013 and 2025. Median age at transformation was 71 years.
Alexandros Rampotas +35 more
wiley +1 more source
Cancer Science, EarlyView.Urinary EVs provide highly pure vesicles with superior DNA quality, making them a robust and completely non‐invasive source for molecular profiling. Urinary EV‐DNA–based MRD assessment shows significant prognostic value and may serve as a practical tool for postoperative monitoring and risk stratification in colorectal cancer.
Shintaro Kanaka +14 more
wiley +1 more source
Cancer Science, EarlyView.Daunorubicin dose escalation from 45 to 60 mg/m2 provides no clinical benefit for AML patients aged 55–65. A dose of 45 mg/m2 should remain the preferred regimen for this population. ABSTRACT Daunorubicin dose optimization remains crucial for AML treatment.
Chunlin Zhou +15 more
wiley +1 more source
Cancer Science, EarlyView.This study provides the first comprehensive characterization of the functional impact, and mechanistic role of FAT4 in MM. Our findings highlight the tumor‐suppressive role of FAT4 in MM and uncover a novel mechanism by which FAT4 regulates the Hippo/YAP pathway.
Lina Zhang +5 more
wiley +1 more source
Cancer Science, EarlyView.Whole‐genome sequencing of ~50,000 individuals from the Tohoku Medical Megabank (TMM) cohort defines the prevalence, mutational landscape, and age dependency of clonal hematopoiesis in the Japanese population, demonstrating overall concordance with clonal hematopoiesis detected in cancer patients.
SungGi Chi +12 more
wiley +1 more source
Emerging applications of large language models in ecology and conservation science
Conservation Biology, EarlyView.Abstract Large language models (LLMs) mark a major development in artificial intelligence, with potentially transformative implications for ecology and conservation science. Built on advanced deep‐learning architectures, these models can support a wide range of tasks. We reviewed emerging applications of LLMs, drawing on the wider scientific literature
Christos Mammides +5 more
wiley +1 more source
Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Ewing sarcoma is an undifferentiated small round cell sarcoma that most commonly presents as a malignant bone tumor in pediatric and young adult patients. The diagnosis is typically confirmed by molecular genetic identification of a fusion protein, most commonly involving members of the FET and ETS gene families.
Jessica L. Muldoon +3 more
wiley +1 more source
Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling
Cytopathology, EarlyView.Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu +3 more
wiley +1 more source