Results 141 to 150 of about 45,512 (293)

NRAS palmitoylation and oncogenic fitness [PDF]

Blood, 2020
openaire   +2 more sources

Incidence, severity and potential pathomechanism of immune‐related pruritus in melanoma patients undergoing immune checkpoint inhibitor therapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Pruritus is a frequent cutaneous immune‐related adverse event (irAE) associated with immune checkpoint inhibitors (ICI), impacting patients' quality of life. This study investigates the incidence, severity and management of pruritus in melanoma patients treated with ICI.
Andrea Roggo, Nikolina Ivanovic, Patrick Turko, Lukas Kraehenbuehl, Mitchell Levesque, Reinhard Dummer, Barbara Meier‐Schiesser   +6 more
wiley   +1 more source

Traditional serrated adenoma of the colorectum: Evolving concepts in histological classification and terminology

Histopathology, EarlyView.
The definition of the colorectal traditional serrated adenoma (TSA) has evolved to recognize a broader morphological spectrum, including classical, flat and mixed lesions reflecting early development and neoplastic progression. Updated WHO classification highlights the need for consistent terminology to improve recognition and to distinguish TSA from ...
Christophe Rosty, Maurice B. Loughrey, Taiki Hashimoto, Markus Mäkinen, Rish K. Pai, Shigeki Sekine, Rhonda K. Yantiss, Iris D. Nagtegaal   +7 more
wiley   +1 more source

Resolution of Refractory Chylous Effusions With Targeted MEK Inhibition in NRAS Q61R-Driven Kaposiform Lymphangiomatosis: A Case Report. [PDF]

Case Rep Pediatr
Brown G, McNab S, Keogh S, Massie J, Eastaugh L, Pathmanathan L, Bertinetti M, Sullivan M, Orme L, Cloney T, Brown NJ, Tan TY, Quin R, Pertile M, Moon A, Bekhit E, Penington T.   +16 more
europepmc   +1 more source

Novel and emerging cutaneous soft tissue tumours

Histopathology, EarlyView.
This review outlines the defining histopathological, immunophenotypic and molecular features of novel and emerging cutaneous soft tissue tumours, including hybrid superficial ALK‐rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK‐rearranged epithelioid vascular neoplasm and MITF pathway ...
Saba Shafi, Josephine K Dermawan
wiley   +1 more source

Anatomical location defines distinct molecular subtypes of mucosal melanoma. [PDF]

ESMO Open
Zhou ER, Rusheen J, Baumann R, Ariyan S, Kluger HM, Gabizon-Peretz S.   +5 more
europepmc   +1 more source

GTPase Nras [PDF]

, 2020
openaire   +1 more source

Cutaneous involvement by myeloid leukaemias: challenging cases with important implications

Histopathology, EarlyView.
Myeloid leukaemias and precursors involving the skin are often challenging to diagnose with varied and overlapping clinical and histopathologic features. Nonetheless, they are critical for pathologists to recognize and accurately classify. This review discusses the clinical, histopathological and genetic features of myelodysplasia cutis (A) and ...
Alexandra C. Hristov
wiley   +1 more source

Self-Assessment Methodology for NRAs : Deliverable 5.1

The self-assessment methodology and tool described here has been structured around the ISO 56000 international standard for Innovation Management. It also includes elements of an Open Innovation approach.
Wright, Alex, Workman, Robin, Kokot, Darko, McPherson, Kevin, Sloth, Mette, Arvidsson, Anna K, Yeganeh, Ali   +6 more
core   +1 more source

Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma

Background: NRAS and KIT mutations in melanoma bring implications for prognosis, follow-up, selection into trials and potential future treatment with targeted therapies.
Richardson, Kathryn, Hardy, Steven, Levell, Nick j, McRonald, Fiona, Mistry, Khaylen, Proby, Charlotte, Dawe, Robert, Lavelle, Katrina, Karponis, Dimitrios, Bright, Chloe, Kennedy, Oliver, Venables, Zoe c, Craig, Paul, Pethick, Joanna, Vernon, Sally, Jeffrey, Polly, Ragan, John, Taylor, Siobhan, Lorigan, Paul   +18 more
core   +1 more source