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The Cancer Journal, 2012
Cutaneous melanomas have mutations in the NRAS GTPase in 15% of cases. Compared to melanomas with BRAF mutations, or melanomas "wild-type" for BRAF and NRAS, melanomas with NRAS mutations are more likely to be thicker tumors and to have a higher mitotic rate. Preclinical studies indicate that melanoma cells with NRAS mutations are dependent on NRAS for
Fergal C, Kelleher, Grant A, McArthur
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Cutaneous melanomas have mutations in the NRAS GTPase in 15% of cases. Compared to melanomas with BRAF mutations, or melanomas "wild-type" for BRAF and NRAS, melanomas with NRAS mutations are more likely to be thicker tumors and to have a higher mitotic rate. Preclinical studies indicate that melanoma cells with NRAS mutations are dependent on NRAS for
Fergal C, Kelleher, Grant A, McArthur
openaire +2 more sources
Treatment of NRAS-Mutant Melanoma [PDF]
Current Treatment Options in Oncology, 2015 NRAS mutations in codons 12, 13, and 61 arise in 15-20 % of all melanomas. These alterations have been associated with aggressive clinical behavior and a poor prognosis. Until recently, there has been a paucity of promising genetically targeted therapy approaches for NRAS-mutant melanoma (and RAS-mutant malignancies in general).
Douglas B Johnson +2 more
exaly +3 more sources
SSRN Electronic Journal, 2020
A solution is needed for the gun violence epidemic, where approximately 15,000 innocent persons are shot to death each year. Close analysis reveals that meaningful legislative solutions have failed to move forward. The reason for this failure is the National Rifle Association’s (NRA) stranglehold on federal and state legislators.
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A solution is needed for the gun violence epidemic, where approximately 15,000 innocent persons are shot to death each year. Close analysis reveals that meaningful legislative solutions have failed to move forward. The reason for this failure is the National Rifle Association’s (NRA) stranglehold on federal and state legislators.
openaire +1 more source
Investigating the NRAS 5′ UTR as a target for small molecules
Cell Chemical Biology, 2023Thorkell Andresson
exaly