Results 181 to 190 of about 45,512 (293)

NRAS NP_002515.1:p.Q61P [PDF]

, 2020
openaire   +1 more source

Durable Response to Sotorasib Plus Panitumumab in NRAS G12C-Mutated, Microsatellite Instability-High (MSI-H) Rectal Cancer Refractory to Immunotherapy. [PDF]

Cureus
Karahan L, Arslan S, Dizdar O.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, Volume 20, Issue 10, Page 2393-2409, October 2026.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The CpG island methylator phenotype defines an immune-cold and therapy-resistant subtype of cutaneous melanoma. [PDF]

Front Immunol
Lu W, Sha X, Lei H, Mao C.
europepmc   +1 more source

Clinicopathological Features and Exploratory Outcome Associations of Bone Marrow Fibrosis in Newly Diagnosed Acute Lymphoblastic Leukemia: A Single‐Center Retrospective Cohort Study

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Bone marrow fibrosis (MF) reflects stromal remodeling and has been associated with treatment resistance and adverse outcomes in hematologic malignancies; however, its clinical significance in acute lymphoblastic leukemia (ALL) remains uncertain.
Ying Chen, Si‐Heng Liu, Cen‐Xia Ran, Wu‐Chen Yang, Jia Li, Xian‐Gui Peng, Lei Gao, Li Gao, Yi‐Mei Feng, Qin Wen, Jun Rao, Pei‐Yan Kong, Xi Zhang, Cheng Zhang   +13 more
wiley   +1 more source

Targeting ABL kinases overcomes melanoma immune evasion following resistance to MAPK inhibition. [PDF]

Nat Commun
Tripathi R, Kalal BS, Soni S, Boothe C, Lyon A, Meeks C, He D, Cheng PF, Levesque MP, Liu J, Wang C, Plattner R.   +11 more
europepmc   +1 more source

Potential Benefit of Ruxolitinib in Suspected Ocular and Neurological Transplant‐Associated Thrombotic Microangiopathy After Allogeneic Stem Cell Transplantation: A Case Report and Review

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT We describe a rare case of suspected delayed‐onset TA‐TMA with ocular and neurological involvement following allo‐HSCT. The condition was refractory to standard therapies; neurological improvement was temporally associated with ruxolitinib initiation, suggesting a possible GVHD overlap.
Lise‐Marie Pillet, Antoine Arandilla, Gaëtan Sauvetre, Paul Goupillou, Adrien Lefevre, Maximilien Grall, Antoine Bonnevalle, Bertrand Bourre, Dominique Penther, Sophie Porcheron, Fabrice Jardin, Mustafa Alani, Sydney Dubois, Vincent Camus   +13 more
wiley   +1 more source

Sirolimus outperforms alpelisib in models of <i>NRAS</i> ^<i>Q61R</i> -driven vascular overgrowth. [PDF]

Blood Vessel Thromb Hemost
Merkle S, Alharbi S, Pastura P, McDaniel CG, Le Cras TD.   +4 more
europepmc   +1 more source

Discovery of Genetic Vulnerabilities in NRAS-Mutant Melanoma

New Zealand has the highest incidence of malignant melanoma in the world. Specifically, melanoma with NRAS mutations are of particular clinical concern due to its association with a poor prognosis and lack of specific treatment options.
Gu, Andrea Yijie
core  

An Overlap of Erdheim–Chester Disease and Rosai–Dorfman Disease With Isolated Bone Lesions Presenting a Diagnostic Challenge: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Some of the rarest diseases with cell accumulation in different organs are histiocytoses. Since these diagnoses are uncommon, other differential diagnoses must be excluded. We report a case of a 42‐year‐old man with episodes of knee pain and fever.
Maris Tulk, Reet Kuuse, Maksim Zagura, Hazem M. M. Ali, Liis Vahesaar   +4 more
wiley   +1 more source