Results 171 to 180 of about 200,244 (343)
Advanced Science, EarlyView.Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin +5 more
wiley +1 more source
In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression. [PDF]
, 2019 Early life exposure to fine particulate matter (PM) in air is associated with infant respiratory disease and childhood asthma, but limited epidemiological data exist concerning the impacts of ultrafine particles (UFPs) on the etiology of childhood ...
Chang, Richard C-A +15 more
core
, 2022 Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, 2022, Universidade de Lisboa, Faculdade de Farmácia.
openaire +1 more source
The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression
Hepatology, EarlyView., 2022 Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro +14 more
wiley +1 more source
Journal of Experimental PharmacologyThamer Abdulla Mohammed,1 Munaf H Zalzala2 1Ministry of Health and Environment, The State Company for Marketing Drugs and Medical Appliances, Baghdad, Iraq; 2Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad ...
Mohammed TA, Zalzala MH
doaj
Wearable Thermoelectric Generators for In Vivo Modulation of Insulin Release
Advanced Energy Materials, EarlyView.This work presents a wearable, self‐powered thermoelectric system (IGNITE) that sustainably harvests body heat to electrically stimulate engineered human cells for insulin release. Operating autonomously without batteries, IGNITE achieves glycemic control in diabetic mice, demonstrating a significant advance in bioelectronic medicine and setting the ...
Debasis Maity +2 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.We systematically reviewed conversion therapy for esophageal squamous cell carcinoma and propose a response‐based treatment strategy for cT4b and M1 disease. For cT4b, we emphasize definitive chemoradiotherapy with timed re‐evaluation and selective salvage or chemoselection to surgery; for M1, conversion is reserved for limited‐burden responders with ...
Eisuke Booka, Hiroya Takeuchi
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The experimental type 2 diabetes model in rats induced by streptozotocin and nicotinamide showed that silver nanoparticles synthesized from lemongrass extract modulate blood glucose, water and food intake, and enhance antioxidant enzyme synthesis and weight gains.
Milad Faraji +6 more
wiley +1 more source
Metabolic Dependencies in Pancreatic Cancer. [PDF]
, 2018 Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R. +3 more
core +1 more source