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Natural Nrf2 activators in diabetes
Clinica Chimica Acta, 2015Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. Most strategies include medical treatment and changes in lifestyle and diet. Some nutraceutical compounds have been recognized as adjuvants in diabetes control.
Angélica Saraí, Jiménez-Osorio +2 more
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Cancer Cell Metabolism Featuring Nrf2
Current Drug Discovery Technologies, 2020Although the major role of Nrf2 has long been established as a transcription factor for providing cellular protection against oxidative stress, multiple pieces of research and reviews now claim exactly the opposite. The dilemma - “to activate or inhibit” the protein requires an immediate answer, which evidently links cellular metabolism to the causes
Payal, Chatterjee +4 more
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Nrf2 in alcoholic liver disease
Toxicology and Applied Pharmacology, 2018Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality of liver disorders and a major health issue globally. ALD refers to a spectrum of liver pathologies ranging from steatosis, steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma.
Jing Sun +7 more
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Nrf2 protects against airway disorders
Toxicology and Applied Pharmacology, 2010Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor that regulates antioxidant response elements (AREs)-mediated expression of antioxidant enzyme and cytoprotective proteins. In the unstressed condition, Kelch-like ECH-associated protein 1 (Keap1) suppresses cellular Nrf2 in cytoplasm and drives its ...
Hye-Youn, Cho, Steven R, Kleeberger
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การควบคุมเหนือพันธุกรรมของยีน Nrf2 โดยอนุพันธ์ออกซิเจนที่ว่องไวต่อการลุกลามของมะเร็งตับ
2023อนุพันธ์ออกซิเจนที่ว่องไวถูกสร้างมากขึ้นในมะเร็งมะเร็งทุกชนิดรวมทั้งมะเร็งตับ ทำให้เกิดภาวะเครียดจากออกซิเดชั่นในสภาวะแวดล้อมมะเร็ง (tumor microenvironment) ในงานวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาการแสดงออกของ Nuclear factor erythroid 2-related factor 2 (Nrf2) และ 8-hydroxydeoxyguanosine (8-OHdG) ในชิ้นเนื้อมะเร็งจากผู้ป่วยมะเร็งตับและในเซลล์มะเร็งต ...
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Nrf2, a multi‐organ protector?
The FASEB Journal, 2005ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that binds to the promoter sequence “antioxidant responsive element (ARE)” leading to coordinated up‐regulation of ARE‐driven detoxification and antioxidant genes.
Jong-Min, Lee +7 more
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Biochemical Society. Transactions, 2015
The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner. Due to these key functions, a tight control of NRF2 expression and activity is essential.
Kurinna, Svitlana, Werner, Sabine
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The nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor is a key player in the cellular antioxidant response and it also controls various other functions in a cell-type specific manner. Due to these key functions, a tight control of NRF2 expression and activity is essential.
Kurinna, Svitlana, Werner, Sabine
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Biochemical and Biophysical Research Communications - BBRC, 1997
K. Itoh +11 more
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K. Itoh +11 more
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2011
Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
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Prevention is better than cure. The carcinogenesis could take as long as 20 to 30 years to develop from initiated cells to malignant tumor, therefore providing us various opportunities to prevent the appearance of tumors with the use of chemopreventive compounds in the early stage.
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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
Annual Review of Pharmacology and Toxicology, 2007T. Kensler, N. Wakabayashi, S. Biswal
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