Results 321 to 330 of about 200,244 (343)

NRF2: KEAPing Tumors Protected

Cancer Discovery, 2022
AbstractThe Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of ...
Ray Pillai, Makiko Hayashi, Anastasia-Maria Zavitsanou, Thales Papagiannakopoulos   +3 more
openaire   +2 more sources

Nrf2 in adipocytes

Archives of Pharmacal Research, 2020
White adipocytes play a key role in maintaining whole body energy homeostasis by forming white adipose tissue (WAT). The impairment of WAT formation or WAT dysfunction is clearly associated with severe metabolic disorders. Mature adipocytes are derived from differentiated preadipocytes and are pivotal in energy storage and metabolism.
Zhendi, Wang, Zhuo, Zuo, Lu, Li, Suping, Ren, Tianchang, Gao, Jingqi, Fu, Yongyong, Hou, Yanyan, Chen, Jingbo, Pi   +8 more
openaire   +2 more sources

Mazes of Nrf2 regulation

Biochemistry (Moscow), 2017
Nrf2 transcription factor plays a key role in maintaining cellular redox balance under stress and is a perspective target for oxidative stress-associated diseases. Under normal conditions, Nrf2 transcriptional activity is low due to its rapid ubiquitination and degradation in the 26S proteasome, as well as through various modifications of amino acid ...
N K, Zenkov, P M, Kozhin, A V, Chechushkov, G G, Martinovich, N V, Kandalintseva, E B, Menshchikova   +5 more
openaire   +2 more sources

Pterostilbene-mediated Nrf2 activation: Mechanistic insights on Keap1:Nrf2 interface

Bioorganic & Medicinal Chemistry, 2016
The discovery of Keap1-Nrf2 protein-protein interaction (PPI) inhibitors has become a promising strategy to develop novel lead molecules against variety of stress. Hence, Keap1-Nrf2 system plays an important role in oxidative/electrophilic stress associated disorders. Our earlier studies identified pterostilbene (PTS), a natural analogue of resveratrol,
Elango, Bhakkiyalakshmi, Kesavan, Dineshkumar, Suresh, Karthik, Dornadula, Sireesh, Waheeta, Hopper, Ramasamy, Paulmurugan, Kunka Mohanram, Ramkumar   +6 more
openaire   +2 more sources

Unfolding Nrf2 in diabetes mellitus

Molecular Biology Reports, 2021
In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing diabetes. The recent advancements in elucidation of ARE/keap1/Nrf2 pathway can help in better understanding of diabetes mellitus.
Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Eshita Sharma, Arun Kumar, Madhuri Grover, Simona Bungau   +6 more
openaire   +2 more sources

Natural Nrf2 activators in diabetes

Clinica Chimica Acta, 2015
Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. Most strategies include medical treatment and changes in lifestyle and diet. Some nutraceutical compounds have been recognized as adjuvants in diabetes control.
Angélica Saraí, Jiménez-Osorio, Susana, González-Reyes, José, Pedraza-Chaverri   +2 more
openaire   +2 more sources

Cancer Cell Metabolism Featuring Nrf2

Current Drug Discovery Technologies, 2020
Although the major role of Nrf2 has long been established as a transcription factor for providing cellular protection against oxidative stress, multiple pieces of research and reviews now claim exactly the opposite. The dilemma - “to activate or inhibit” the protein requires an immediate answer, which evidently links cellular metabolism to the causes
Payal, Chatterjee, Mukesh, Yadav, Namrata, Chauhan, Ying, Huang, Yun, Luo   +4 more
openaire   +2 more sources

Nrf2 in alcoholic liver disease

Toxicology and Applied Pharmacology, 2018
Alcoholic liver disease (ALD) is a leading cause of morbidity and mortality of liver disorders and a major health issue globally. ALD refers to a spectrum of liver pathologies ranging from steatosis, steatohepatitis, fibrosis, cirrhosis and even hepatocellular carcinoma.
Jing Sun, Jingqi Fu, Lu Li, Chengjie Chen, Huihui Wang, Yongyong Hou, Yuanyuan Xu, Jingbo Pi   +7 more
openaire   +2 more sources