Results 121 to 130 of about 12,817 (217)

Study on transactivation mechanism Hepatitis C Virus NS5A protein

, 2014
C型肝炎是造成非A非B型肝炎的主要原因，持續慢性C型肝炎感染可能導致肝癌。C型肝炎的NS5A詳細功能仍未被完全瞭解，在本研究中我們希望能進一步瞭解NS5A在肝癌演變過程中所扮演的角色。已知NS5A蛋白具有一段可能有功能的核轉位訊號（nuclear localization signal ; NLS），此蛋白之某一區段並具有活化轉錄能力。於是我們從肝癌病人血清中取得HCV基因組，並選取產生NS5A蛋白的基因序列區段來探討轉錄活化之機轉。使用一個NS5A-HCC及二個NS5A突變株質體送到Huh-7細胞表現。
昌美惠, Chang, Mei-Hui
core  

The 36V mutation altered NS5A subcellular localization and NS5A-core co-localization without affecting NS5A-core interaction affinity.

, 2018
(A) Diagram of HJ3-5 encoding YFP-fused NS5A with 36V mutation at the top, and Western blot of NS5A, NS3 and tubulin at the bottom. (B) Virus titers from HJ3-5/NS5AYFP and 36V mutant are shown.
Alyssa K. Nichols (5545664), MinKyung Yi (362029), Saravanabalaji Shanmugam (5545667), Dhanaranjani Saravanabalaji (5545670), Christoph Welsch (22852)   +4 more
core   +1 more source

Structural studies on hepatitis C virus (HCV) NS5A and its molecular interaction with CypA

, 2015
Hepatitis C virus infection is a worldwide issue and its NS5A protein interacts with host Cyclophilin A to play a crucial role in viral replication. To date, there is limited structural information for the intrinsically disordered NS5A protein. Here, low-
Lee, Jia Jun
core  

Unravelling HCV diversity and resistance in Viet Nam: a cross-sectional analysis. [PDF]

Lancet Reg Health West Pac
Le Ngoc C, Chai H, Airey G, Das T, Jennings D, Xu F, Flower B, Marjaneh MM, McCabe L, Le Manh H, Nguyen Van Vinh C, Trong TD, Ngoc TP, Thi Thu HV, Thwaites GE, van Doorn HR, Day J, Kestelyn E, Le Van T, Rahman M, Pett S, Barnes E, Walker AS, Cooke GS, Ansari MA.   +24 more
europepmc   +1 more source

A Database-Derived Global Overview of HCV Resistance-Associated Substitutions: Characterizing Genotypic, Regional, and Temporal Heterogeneity. [PDF]

Int J Mol Sci
Nunes GTM, Sant'Anna TBF, de Araujo NM.
europepmc   +1 more source

The Role of NS5A in Chronic HCV Infection

, 2015
Hepatitis C is a viral disease that affects the liver cells of the infected individual, resulting in inflammation and frequent liver failure. Currently 150-200 million people worldwide are infected with Hepatitis C and 85% of these incidences have ...
Simkins, Allison
core  

Immunogenicity of a Candidate Hepatitis C Vaccine Based on Non-Structural DNA-Protein Sequences and a Novel Complex Adjuvant. [PDF]

Vaccines (Basel)
Masalova OV, Lesnova EI, Kozlov VV, Valuev-Elliston VT, Permyakova KY, Fedorova NE, Nikolaeva TN, Pronin AV, Ivanov AV, Kushch AA.   +9 more
europepmc   +1 more source

BVDV NS5A Binds to CKAP2 and Activates the PI3K/AKT/mTOR Pathway to Facilitate Virus Transmission Through Tunneling Nanotubes. [PDF]

Vet Sci
Yin J, Zhu Y, Zhang J, Zhou Z, He N, Zhou H, Liu X, Zhao Y, Zhao L, Zong Y, Diao N, Shi K, Li N, Du R.   +13 more
europepmc   +1 more source

Direct-Acting Antiviral Therapy and Hepatocellular Carcinoma in Captive Chimpanzees With Long-Standing Chronic Hepatitis C Virus Infection. [PDF]

J Med Virol
Hirata S, Nogami E, Udono T, Fujisawa M, Tanaka Y.   +4 more
europepmc   +1 more source

Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling. [PDF]

Sci Adv
Bulankina AV, Richter RM, Nettles JH, Yamane D, Grimm C, Karami Y, Stanton RA, Introini B, Hermann J, Charif H, König MS, Stroß C, Ortiz C, Kraus N, Wood D, Galceran F, Abele R, Maigret B, Schinazi RF, Zeuzem S, Biondi RM, Yi M, Tampé R, Kudryashev M, Welsch C.   +24 more
europepmc   +1 more source