Results 101 to 110 of about 17,579 (227)

Response to combination therapy of HCV 3a infected Pakistani patients and the role of NS5A protein [PDF]

, 2011
Background Hepatitis C virus (HCV) genotype 3a is known to show comparatively better response to combination therapy than genotype 1 and 4.
Ijaz Ali, Sanaullah Khan, Sobia Attaullah, Shahid Khan, Jabbar Khan, Sami Siraj, Aqib Iqbal, Zahoor A Swati, Muhammad Idrees   +8 more
core   +1 more source

Classical swine fever virus NS5B protein suppresses the inhibitory effect of NS5A on viral translation by binding to NS5A

Journal of General Virology, 2012
In order to investigate molecular mechanisms of internal ribosome entry site (IRES)-mediated translation in classical swine fever virus (CSFV), an important pathogen of pigs, the expression level of NS3 was evaluated in the context of genomic RNAs and reporter RNA fragments.
Chun, Sheng, Jing, Wang, Jing, Xiao, Jun, Xiao, Yan, Chen, Lin, Jia, Yimiao, Zhi, Guangyuan, Li, Ming, Xiao   +8 more
openaire   +2 more sources

Small Molecule Targeting of Atypical p38 Protects Against Viral Infection

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Targeting host signaling pathways offers a complementary strategy to direct‐acting antivirals. Small‐molecule modulators of atypical p38 block Hepatitis C virus replication and also inhibit Human Cytomegalovirus. By disrupting virus‐induced p38 activation, these compounds suppress viral RNA replication and protein expression, highlighting atypical p38 ...
Fredejah T. Royer, Jeremy C. Burton, Johnathan Burns, Megan G. Lloyd, Reuben Onwe, Jennifer F. Moffat, Neil J. Grimsey   +6 more
wiley   +1 more source

Prevalence of NS5A resistance associated substitutions in patients with hepatitis C virus genotypes 1a and 3: Impact on current therapeutic strategies [PDF]

, 2018
[Abstract] The presence of resistance‐associated substitutions (RASs) at NS5A region might compromise the efficacy of Direct Acting Antiviral agents (DAAs).
Bagaglio, Black, Calleja, Chen, Dietz, Foster, Kalaghatgi, Lindström, Nelson, Palladino, Paolucci, Pawlotsky, Plaza, Poveda, Poveda, Pérez, Sarrazin, Wyles, Zeuzem, Zeuzem, Zeuzem   +20 more
core   +2 more sources

From Guidelines to Real‐Time Conversation: Expert‐Validated Retrieval‐Augmented and Fine‐Tuned GPT‐4 for Hepatitis C Management

Liver International, Volume 45, Issue 10, October 2025.
ABSTRACT Background and Aims Advances in artificial intelligence, particularly large language models (LLMs), hold promise for transforming chronic disease management such as Hepatitis C Virus (HCV) infection. This study evaluates the impact of retrieval‐augmented generation (RAG) and supervised fine‐tuning (SFT) on both open‐ended question answering ...
Mauro Giuffrè, Nicola Pugliese, Simone Kresevic, Milos Ajcevic, Francesco Negro, Massimo Puoti, Xavier Forns, Jean‐Michel Pawlotsky, Dennis L. Shung, Alessio Aghemo   +9 more
wiley   +1 more source

Sequencing of E2 and NS5A regions of HCV genotype 3a in Brazilian patients with chronic hepatitis [PDF]

, 2010
Hepatitis C virus (HCV) is a major cause of liver disease throughout the world. The NS5A and E2 proteins of HCV genotype 1 were reported to inhibit the double-stranded (ds) RNA-dependent protein kinase (PKR), which is involved in the cellular antiviral ...
AZEVEDO, Raymundo Soares de, CARRILHO, Flair José, GONÇALVES, Luzia, MALTA, Fernanda de Mello, MEDEIROS-FILHO, José Eymard Moraes de, PINHO, João Renato Rebello, SILVA, Luiz Caetano da   +6 more
core   +3 more sources

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, Volume 12, Issue 36, September 25, 2025.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Genetic diversity of NS5A protein from hepatitis C virus genotype 3a and its relationship to therapy response

BMC Infectious Diseases, 2010
Background The quasispecies nature of HCV may have important implications for viral persistence, pathogenicity and resistance to antiviral agents. The variability of one of the viral proteins, NS5A, is believed to be related to the response to IFN ...
Rahal Paula, de Carvalho-Mello Isabel, Pinho João, de Queiróz Artur TL, Carareto Claudia MA, Yamasaki Lilian HT, Jardim Ana, Bittar Cíntia   +7 more
doaj   +1 more source

Early events in the generation of autophagosomes are required for the formation of membrane structures involved in hepatitis C virus genome replication [PDF]

, 2016
Hepatitis C virus (HCV) infection has been shown to induce autophagy but the mechanisms underpinning this process remain to be elucidated.
Bartlett, C, Harris, M, Mankouri, J, Mohl, B   +3 more
core   +1 more source

Study on Antibacterial Activity of Water Extract of Galla chinensis Against Carbapenemase‐Producing Enterobacteriaceae

MicrobiologyOpen, Volume 14, Issue 4, August 2025.
Galla chinensis is an eco‐friendly and effective alternative to traditional antibiotics for combating multidrug resistance. ABSTRACT Carbapenemase‐producing Enterobacteriaceae (CPE) represents a significant global public health concern, largely driven by factors including misuse of antibiotics and their inappropriate use in livestock.
MinHui Miao, Jiayao Lin, Jie Zhu, Hong Du, Di Mei, AnQi Gu, BeiNa Hu, HaiQiang Jiang   +7 more
wiley   +1 more source