Results 91 to 100 of about 17,579 (227)
Quantitative Analysis of Hepatitis C NS5A Viral Protein Dynamics on the ER Surface
Viruses, 2018 Exploring biophysical properties of virus-encoded components and their requirement for virus replication is an exciting new area of interdisciplinary virological research.
Markus M. Knodel +7 more
doaj +1 more source
Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A [PDF]
, 2019 Hepatitis C virus (HCV) utilizes autophagy to promote its propagation. Here we show the autophagy-mediated suppression of HCV replication via the endoplasmic reticulum (ER) protein SCOTIN.
Eui-Cheol Shin +5 more
core +1 more source
Health Benefits and Therapeutic Potential of Quercetin
Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.Quercetin, a polyphenolic compound prevalent in many fruits, vegetables, and other dietary sources, has attracted considerable interest due to its extensive health benefits. This review examines its diverse biological properties, particularly its antioxidant and anti‐inflammatory effects. The study integrates recent scientific findings to elucidate the
Mahendra Aryal, Kim Wei Chan
wiley +1 more source
PLoS ONE, 2015 BackgroundHepatitis C virus (HCV) infection is one of the major causes of cirrhosis and hepatocellular carcinoma. HCV nonstructural protein 5A (NS5A) is an attractive antiviral target and plays an important role in HCV replication as well as ...
Xia Jiang +9 more
doaj +1 more source
Журнал инфектологии, 2018 Aim. To determine the prevalence of amino acid substitutions in hepatitis C virus NS5a and core proteins which are associated with resistance to direct-acting antivirals and interferon in genotype 1b (HCV-1b) strains circulating in Russia.
V. S. Kichatova +6 more
doaj +1 more source
Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance
Hepatology Communications, 2020 Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, but drug resistance could undermine proposed global elimination targets.
Mark W. Douglas +14 more
doaj +1 more source
Update on hepatitis C virus resistance to direct-acting antiviral agents [PDF]
, 2014 Review[Abstract] Resistance to direct-acting antiviral (DAA) agents against hepatitis C virus (HCV) infection is driven by the selection of mutations at different positions in the NS3 protease, NS5B polymerase and NS5A proteins.
Cachay, Edward +5 more
core +2 more sources
Recent Advancements in Known and Emerging Risk Factors of Hepatocellular Carcinoma
Cancer Medicine, Volume 14, Issue 21, November 2025.ABSTRACT Background Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and a leading cause of cancer‐related deaths worldwide. Despite advancements in antiviral therapies for hepatitis B (HBV) and hepatitis C (HCV), HCC incidence continues to rise due to metabolic dysfunction‐associated steatotic liver disease (MASLD), obesity ...
Muhammad Masroor Hussain +5 more
wiley +1 more source
Hepatitis C virus nonstructural protein 5A inhibits thapsigargin-induced apoptosis.
PLoS ONE, 2014 BackgroundWe previously reported that the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) down-regulates TLR4 signaling and lipopolysaccharide-induced apoptosis of hepatocytes. There have been several reports regarding the association between HCV
Xia Jiang +6 more
doaj +1 more source
DEB025 (Alisporivir) inhibits hepatitis C virus replication by preventing a cyclophilin A induced cis-trans isomerisation in domain II of NS5A. [PDF]
PLoS ONE, 2010 DEB025/Debio 025 (Alisporivir) is a cyclophilin (Cyp)-binding molecule with potent anti-hepatitis C virus (HCV) activity both in vitro and in vivo. It is currently being evaluated in phase II clinical trials.
Lotte Coelmont +15 more
doaj +1 more source